Reversed aqueductal cerebrospinal fluid net flow in idiopathic normal pressure hydrocephalus

Yin, Lina; Zheng, Jiajun; Zhao, Liandong; Hao, Xiang; Zhang, X. X.; Tian, Jiaqi; Zheng, Kewen; Yang, Yanmei

doi:10.1111/ane.12750

Cited by 28 publications

(30 citation statements)

References 24 publications

(61 reference statements)

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“…In iNPH, gadobutrol entered the ventricular system early, remained in the ventricles over time, and correlated strongly with contrast enhancement in adjacent periventricular white matter, indicating transependymal migration of the contrast agent, which in its turn was associated with periventricular hyperintensity at FLAIR images. These observations support previous findings of net retrograde aqueductal flow in iNPH ( Ringstad et al , 2016 ; Yin et al , 2017 ), and this phenomenon has also been associated with restricted intracranial pulsations and change of net flow in the antegrade direction after surgical shunting ( Ringstad et al , 2016 ). Aqueductal net flow is typically reported in microlitres, which might be within the range of measurement inaccuracies, and has by some been considered a sign of measurement inaccuracy when it is observed, and therefore been subtracted when estimating the more robust parameter aqueductal stroke volume to predict shunt response in NPH ( Bradley et al , 1996 ).…”

Section: Discussionsupporting

confidence: 91%

Glymphatic MRI in idiopathic normal pressure hydrocephalus

Ringstad

Vatnehol

Eide

2017

Brain

477

573

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Section: Discussionsupporting

confidence: 91%

Glymphatic MRI in idiopathic normal pressure hydrocephalus

Ringstad

Vatnehol

Eide

2017

Brain

477

573

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“…Earlier work indicated that the altered CSF flow dynamic may be the reason for ventriculomegaly present in the iNPH patients, and speculated that the real root may lie in brain parenchyma (Yin et al, 2017 ). Most of the previous studies were dedicated to finding one or more anatomical regions responsible for the occurrence of the disease, such as the morphological changes of ventricles, fissures, WM, or GM (Halperin et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen iNPH patients and 20 controls were included in our earlier work that dealt with the changes of CSF flow though aqueduct (Yin et al, 2017 ). In contrast in this manuscript, we report the changes of the structural network.…”

Section: Methodsmentioning

confidence: 99%

Abnormal Gray Matter Structural Networks in Idiopathic Normal Pressure Hydrocephalus

Yin

Zheng

Tian

et al. 2018

Front. Aging Neurosci.

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Purpose: Idiopathic normal pressure hydrocephalus (iNPH) is known as a treatable form of dementia. Network analysis is emerging as a useful method to study neurological disorder diseases. No study has examined changes of structural brain networks of iNPH patients. We aimed to investigate alterations in the gray matter (GM) structural network of iNPH patients compared with normal elderly volunteers.Materials and Methods: Structural networks were reconstructed using covariance between regional GM volumes extracted from three-dimensional T1-weighted images of 29 possible iNPH patients and 30 demographically similar normal-control (NC) participants and compared with each other.Results: Global network modularity was significantly larger in the iNPH network (P < 0.05). Global network measures were not significantly different between the two networks (P > 0.05). Regional network analysis demonstrated eight nodes with significantly decreased betweenness located in the bilateral frontal, right temporal, right insula and right posterior cingulate regions, whereas only the left anterior cingulate was detected with significantly larger betweenness. The hubs of the iNPH network were mostly located in temporal areas and the limbic lobe, those of the NC network were mainly located in frontal areas.Conclusions: Network analysis was a promising method to study iNPH. Increased network modularity of the iNPH group was detected here, and modularity analysis should be paid much attention to explore the biomarker to select shunting-responsive patients.

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“…This highlights the importance of such correction to better rate patients with altered cerebral hydrodynamic and/or hemodynamic. Recent studies on idiopathic normal pressure hydrocephalus have shown that there was a reversed Q Net direction compared to the healthy controls [18], or patient following surgical shunt [19]. Other studies have shown no difference in terms of Q Net magnitude and directions [20].…”

Section: Discussionmentioning

confidence: 98%

Fold-Over Oversampling Effects in the Measurements of Cerebral Cerebrospinal Fluid and Blood Flows with 2D Cine Phase-Contrast MRI

et al. 2020

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This prospective study investigated the effects of fold-over oversampling on phase-offset background errors with 2D-Cine phase contrast (Cine-PC) magnetic resonance imaging (MRI). It was performed on brain MRI and compared to conventional Full-field of view FOV coverage and it was tested with two different velocity encoding (Venc) values. We chose Venc = 100 mm/s to encode cerebrospinal fluid (CSF) flows in the aqueduct and 600 mm/s to encode blood flow in the carotid artery. Cine-PC was carried out on 10 healthy adult volunteers followed simultaneously by an acquisition on static agar-gel phantom to measure the phase-offset background errors. Pixel-wise correction of both the CSF and the blood flows was calculated through 32 points of the cardiac-cycle. We compared the velocity-to-noise ratio, the section area, the absolute and the corrected velocity (peak; mean and minimum), the net flow, and the stroke volume before and after correction. We performed the statistical T-test to compare Full-FOV and fold-over and Bland–Altman plots to analyze their differences. Our results showed that following phase-offset error correction, the blood stroke-volume was significantly higher with Full-FOV compared to fold-over. We observed a significantly higher CSF mean velocity and net flow values in the fold-over option. Compared to Full-FOV, fold-over provides a significantly larger section area and significantly lower peak velocity-offset in the aqueduct. No significant difference between the two coverages was reported before and after phase-offset in blood flow measurements. In conclusion, fold-over oversampling can be chosen as an alternative to increase spatial resolution and accurate cerebral flow quantification in Cine-PC.

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Reversed aqueductal cerebrospinal fluid net flow in idiopathic normal pressure hydrocephalus

Cited by 28 publications

References 24 publications

Glymphatic MRI in idiopathic normal pressure hydrocephalus

Glymphatic MRI in idiopathic normal pressure hydrocephalus

Abnormal Gray Matter Structural Networks in Idiopathic Normal Pressure Hydrocephalus

Fold-Over Oversampling Effects in the Measurements of Cerebral Cerebrospinal Fluid and Blood Flows with 2D Cine Phase-Contrast MRI

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