Reverse Translational Research - How Clinical Trials on Fluorescence Imaging for Vocal Cord Cancer Fuels Fundamental Research

Abstract

Translational research consists in translating fundamental research results as closely as possible to patients. Researchers sometimes underestimate these studies because it is thought that, although essential for setting up new investigation tools, they do not deepen fundamental knowledge. However, users face specific difficulties due to the variability of the biological systems under study. Variability is easily understood from one patient to another, but there is also variability in a single patient whose metabolism evolves together with therapeutic actions. Results obtained in translational research often depend on this variability, and new questions and scientific obstacles arise when research is applied to the real world. In order to address these new challenges, reverse translational research is required. Fundamental research is fuelled by the results of translational research. In this position paper, we consider vocal cord fluorescence imaging as an example of bi-directional translational research. First, we briefly recall the basics of fluorescence imaging, and we explain why commercial fluorescence systems lead to variable estimations of their efficiency by end-users. Second, we describe solutions intended to improve fluorescence techniques. This position paper will then make conclusions.