Abstract:The presence of bacteria in the bloodstream is associated with severe clinical outcomes. In mice, intravenous inoculation of
Escherichia coli
can lead to the formation of macroscopic abscesses in the liver. Abscesses are regions of severe necrosis and consist of millions of bacteria surrounded by inflammatory immune cells. Liver abscess susceptibility varies widely across strains of mice, but the host factors governing this variation are unknown. Here, we profiled hepatic transcriptomes… Show more
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