Reverse Takotsubo Cardiomyopathy Precipitated by Chronic Cocaine and Cannabis Use

Nash, Emily; Roberts, Darren M.; Jamshidi, Nazila

doi:10.1007/s12012-021-09692-9

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Cocaine stimulates the sympathetic nervous system by directly inhibiting the reuptake of norepinephrine, dopamine, and serotonin with an increase in the sensitivity of adrenergic nerve endings to norepinephrine as a consequence of this stimulation of the central sympathetic outflow [ 3 ]. Cocaine toxicity can cause myocardial infarctions, myocardial ischemia, coronary vasospasms, arrhythmias, myocarditis, and cardiomyopathy [ 29 ]. Cocaine is ultimately thought to mimic sudden stress and induce a similar sequence of events resulting in microvascular spasm, myocardial stunning, or direct myocardial injury consistent with the diagnosis of TCM [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Arrest (CA) as the Initial Presentation of Cocaine-Induced Takotsubo Cardiomyopathy (TCM): A Case Report and Review of Literature

Almalouf,

Hakobyan,

Yadav

et al. 2023

Cureus

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Cocaine is used as an illicit substance responsible for the most common cause of drug-related death. It is a stimulant that acts on the sympathetic nervous system and cardiovascular system leading to exaggerated, prolonged sympathetic activity due to the accumulation of neurotransmitters. Cardiovascular side effects of cocaine are coronary artery spasms, myocarditis, arrhythmias, and congestive heart failure. Takotsubo cardiomyopathy (TCM) is characterized by transient hypokinesis, akinesis, or dyskinesis of the left ventricle (LV) wall with or without apical involvement in the absence of obstructive coronary artery disease. Cocaine-induced TCM is an extremely rare condition emphasizing the need of its prompt diagnosis by the physicians. We present a case report of a 54-year-old male, brought to the emergency department (ED) after an out-of-hospital cardiac arrest (CA), found to have TCM in the setting of cocaine use. Clinicians need to understand the association between cocaine use and the development of TCM as cardiomyopathy of this type can result in complete remission after discontinuing the offending agent.

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Section: Discussionmentioning

confidence: 99%

Cardiac Arrest (CA) as the Initial Presentation of Cocaine-Induced Takotsubo Cardiomyopathy (TCM): A Case Report and Review of Literature

Almalouf,

Hakobyan,

Yadav

et al. 2023

Cureus

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“…This has been postulated to be secondary to a higher frequency of adrenoreceptors expressed in the basal LV wall compared to the apical segment in this age group. Only a small number of cases of bTTS have been reported in association with seizure disorders (Table 1) [26][27][28][29][30]. Although TTS largely involves the left ventricle, recent evidence suggests that almost one-third of cases involve both ventricles [34,35].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, an extensive review performed by Stollberger et al described only two cases of bTTS associated with epileptic seizures [25]. Aside from the cases included in this review, only a small number of cases have been published [26][27][28][29][30]. The underlying mechanism linking seizures and TTS is believed to be an acute catecholamine surge resulting in autonomic dysfunction and coronary artery spasm.…”

Section: Introductionmentioning

confidence: 97%

Basal type Takotsubo Syndrome in the post-ictal period – A case report highlighting the importance of post-ictal cardiac evaluation

O’Neill

Maudlin

Cho

et al. 2022

Preprint

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Takotsubo syndrome (TTS) is a reversible form of left ventricular dysfunction commonly associated with physical or emotional stress. It is characterised by chest pain and elevated troponin levels, thereby mimicking acute coronary syndrome however there is typically no evidence of obstructive coronary artery disease on invasive angiography. TTS is characterised by apical ballooning or akinesis with basal hyperkinesia. Basal type Takotsubo Syndrome (bTTS) is a less common atypical variant identified by basal akinesis and apical hyperkinesis. Although both forms have been shown to be associated with neurological disease and intracranial haemorrhage or ischaemic stroke, bTTS in the context of epileptiform seizures is relatively rare but an important diagnosis to recognise. We describe a case of a 73-year-old woman who presented to hospital with generalised tonic clonic seizures, followed by centralised chest pain, troponin elevation due to bTTS. This case describes an uncommon presentation of bTTS and highlights the importance of cardiac assessment in patients presenting with generalised tonic-clonic seizures.

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“…But when a patient presents with an atypical pattern, the TS diagnosis is so much more difficult. In such cases, CMR is of unquestionable benefit [ 122 ] (Table 2 ). The positive and differential diagnosis in TS is a complex one, starting from the clinical arguments of TS likelihood and ischemic risk, and oftentimes extending beyond echocardiography and coronary artery imaging to magnetic resonance myocardial description (Fig.…”

Section: Cardiac Magnetic Resonancementioning

confidence: 99%

An Extensive Review on Imaging Diagnosis Methods in Takotsubo Syndrome

Paraschiv,

Paduraru,

Balanescu

2023

Rev. Cardiovasc. Med.

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Takotsubo Syndrome (TS) is an acute, reversible cardiac dysfunction, with complex, not entirely understood pathophysiology and heterogeneous clinical picture. Imaging methods each have a crucial role in the diagnosis, in-hospital management, short term and long term follow up. Coronary angiography needs to be performed, especially in the setting of a suspected acute coronary syndrome, in order to rule out coronary artery disease. Echocardiography plays a central role both in the acute and the chronic phase. It is the first imaging investigation performed in patients with TS, valuable to diagnose systolic dysfunction, the wall motion pattern and early complications. Cardiac magnetic resonance tissue characterization provides an essential role in the differential diagnosis of TS with other non-ischemic causes of systolic dysfunction. This review focuses on the imaging methods and the important part they play in the complex management of the disease.

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Reverse Takotsubo Cardiomyopathy Precipitated by Chronic Cocaine and Cannabis Use

Cited by 6 publications

References 34 publications

Cardiac Arrest (CA) as the Initial Presentation of Cocaine-Induced Takotsubo Cardiomyopathy (TCM): A Case Report and Review of Literature

Cardiac Arrest (CA) as the Initial Presentation of Cocaine-Induced Takotsubo Cardiomyopathy (TCM): A Case Report and Review of Literature

Basal type Takotsubo Syndrome in the post-ictal period – A case report highlighting the importance of post-ictal cardiac evaluation

An Extensive Review on Imaging Diagnosis Methods in Takotsubo Syndrome

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