Reverse Micelle Formation Of The Dipeptide Boc- Ile-Ile-NHMe

Abstract

The dipeptide derivative Boc-Ile-Ile-NHMe synthesized in our laboratory is found to form reverse micelles in the presence of water in chloroform solvent. Reverse micelles finds it's importance in the field of drug delivery. The critical micellar concentration (cmc) has been determined by varying the temperature for each R value, where R is the ratio of water to peptide concentration. The R value has been changed from a minimum value of 0.52 to a maximum value of 10. The aggregation number has also been determined for the micelles formed for different R values at room temperature. The change in the micropolarity of the micellar environment has also been monitored using pyrene. The thermodynamic parameters G m , H m and S m has also been determined for the system.