Abstract:Nonsmall cell lung cancer (NSCLC), driven by KRAS gene mutations, is a highly malignant disease currently lacking targeted medicines, except for a specific G12C mutation. However, nanotechnology-based interventions and nanomedicines hold great promise as alternatives to traditional chemotherapy. In this study, we propose a reverse engineering strategy to design and assemble DNA and RNA hybrid origami nanostructures as nanomedicines for the therapy of KRAS-mutated NSCLC. Instead of using M13 DNA as a scaffold f… Show more
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