2008
DOI: 10.1093/bja/aen037
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Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine

Abstract: Sugammadex 2.0 mg kg(-1) administered at reappearance of T(2) was significantly faster in reversing rocuronium-induced blockade than neostigmine was in reversing cisatracurium-induced block.

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Cited by 109 publications
(77 citation statements)
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“…13 A significant difference in moderate block recovery times was also reported between rocuronium with sugammadex compared with cisatracurium with neostigmine/glycopyrrolate. 12 Similar trends were also observed for recovery from moderate block to a TOFR¼0.8 and 0.7, P,0.00001 (primary authors' analysis). 12 Clinical signs of recovery from moderate block were reported for the comparison of rocuronium/sugammadex and cisatracurium/neostigmine/glycopyrrolate, 12 with 22 out of 34 patients (65%) in the sugammadex group and 27 of 39 patients (69%) in the neostigmine/glycopyrrolate group awake and orientated before transfer to the recovery room.…”
Section: Clinical Efficacysupporting
confidence: 65%
See 1 more Smart Citation
“…13 A significant difference in moderate block recovery times was also reported between rocuronium with sugammadex compared with cisatracurium with neostigmine/glycopyrrolate. 12 Similar trends were also observed for recovery from moderate block to a TOFR¼0.8 and 0.7, P,0.00001 (primary authors' analysis). 12 Clinical signs of recovery from moderate block were reported for the comparison of rocuronium/sugammadex and cisatracurium/neostigmine/glycopyrrolate, 12 with 22 out of 34 patients (65%) in the sugammadex group and 27 of 39 patients (69%) in the neostigmine/glycopyrrolate group awake and orientated before transfer to the recovery room.…”
Section: Clinical Efficacysupporting
confidence: 65%
“…12 Similar trends were also observed for recovery from moderate block to a TOFR¼0.8 and 0.7, P,0.00001 (primary authors' analysis). 12 Clinical signs of recovery from moderate block were reported for the comparison of rocuronium/sugammadex and cisatracurium/neostigmine/glycopyrrolate, 12 with 22 out of 34 patients (65%) in the sugammadex group and 27 of 39 patients (69%) in the neostigmine/glycopyrrolate group awake and orientated before transfer to the recovery room. The majority of patients in both treatment groups were reported to be co-operative, able to perform a five second head lift, and did not experience muscle weakness before transfer to, or before discharge from, the recovery room.…”
Section: Clinical Efficacysupporting
confidence: 65%
“…Bununla birlikte nöromusküler bloker kullanılan operasyonlarda rezidüel kürarizasyon riski vardır. Anestezi sonrasında nöromusküler kavşak yeterli düzeyde derlenmezse postoperatif pulmoner komplikasyonların gelişimi ve mortalite artar [4,7]. Günümüzde geleneksel olarak neostigmin ve piridostigmin gibi kolinesteraz inhibitörleri, nöromusküler bloker ajanların etkisini antagonize etmek için kullanılır.…”
Section: Discussionunclassified
“…Ayrıca bu ilaçların istenmeyen kardiyovasküler, solunumsal ve kolinerjik yan etkileri sık görülür [2][3][4]. Son yıllarda steroid yapıdaki nöromusküler bloker ajanlarda modifiye γ-siklodekstrin yapısındaki sugammadeks kullanılarak, kolinesteraz inhibitörleri ile yapılan geleneksel dekürarizasyon işlemine güncel bir alternatif sunulmaktadır [3][4][5]. Bu sunumda geleneksel antikolinerjik ajanların başarısız olduğu roküronyuma bağlı rezidüel kürarizasyonda sugammadeks kullanımının güvenliği ve etkinliği tartışıldı.…”
Section: Introductionunclassified
“…However, cholinesterase inhibitors are ineffective in reversing the profound neuromuscular block. Furthermore, undesirable cardiovascular, respiratory and cholinergic side effects of these drugs are very common (3,4). In recent years, sugammadex has been used for the decurarisation of the neuromuscular block brought about by steroidal neuromuscular blockers as an alternative to cholinesterase inhibitors.…”
Section: Introductionmentioning
confidence: 99%