Reversal of photodamage with topical growth factors: a pilot study

Fitzpatrick, Richard; Rostan, Elizabeth F.

doi:10.1080/14764170310000817

Cited by 126 publications

(55 citation statements)

References 77 publications

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“…In this process, variable cytokines such as IGF, EGF, IL-1, TNF-a, TGF-b and growth factors participate in collagen synthesis (21,22). At first, these factors are released from platelets, and then variable cytokines and growth factors are secreted from inflammatory cells and fibroblasts, which act as the target tissue (22). In this study, ulcers treated with stem cells showed more expression of collagen gene than ulcers that received saline alone in the control group.…”

Section: Discussionmentioning

confidence: 99%

Adipose Stem Cells as Alternatives for Bone Marrow Mesenchymal Stem Cells in Oral Ulcer Healing

Aly¹,

Menoufy²,

Ragae³

et al. 2012

Int J Stem Cells

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Section: Discussionmentioning

confidence: 99%

Adipose Stem Cells as Alternatives for Bone Marrow Mesenchymal Stem Cells in Oral Ulcer Healing

Aly¹,

Menoufy²,

Ragae³

et al. 2012

Int J Stem Cells

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“…Skin damage and skin aging may be caused due to a combination of various intrinsic factors, such as chronological aging or extrinsic factors, such as ultraviolet (UV) rays (photo-aging) and other environmental stressors [1]. Aging of the skin at the cellular level caused due to these factors, is manifested by the development of sagging skin, onset of wrinkling, appearance of blemishes or age spots, altered pigmentation or loss of skin tone and hydration [1] [2] [3]. These changes may progressively increase, leading to serious skin health problems [2].…”

Section: Introductionmentioning

confidence: 99%

“…These changes may progressively increase, leading to serious skin health problems [2]. Various medical treatments and topical cosmeceuticals have been used to treat some symptoms of photo-aging; however, the results have been less than satisfactory [3]. The advances made in the past decades have been associated with clinical, biochemical and molecular changes of dermal aging which has led to the development of various products intended to reduce, delay, and in some cases, repair the untoward effects of programmed ageing and external environmental damage [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Secretome Profile and Functional Characteristics of Human Bone Marrow Mesenchymal Stromal Cells-Derived Conditioned Medium Suggest Potential for Skin Rejuvenation

Balasubramanian¹,

Thej²,

Walvekar³

et al. 2017

JCDSA

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Background/Purpose: Multipotent bone marrow-derived mesenchymal stromal cells (BMMSC) have been shown to possess the potential for tissue regeneration. The application of mesenchymal stromal cells (MSC)-derived growth factors and cytokines (GF/CKs) has been implicated for the repair and regeneration of the damaged skin that occurs due to aging and exposure to environmental stress factors. Methods: We have used both qualitative and quantitative measurements of the GF/CKs from the conditioned medium (CM) of a pooled population of BMMSC by antibody array analysis as well as by enzyme-linked immunosorbent assay (ELISA). Furthermore, the CM was also used in a variety of in vitro biological assays to measure its protective properties in human skin fibroblasts. Results: We have characterized the secretome of BMMSC by analyzing the composition of the CM using a forty-one growth factor array system. Thirteen of these GF/CK/extra cellular matrix (ECM)/ matrix metalloproteinases (MMP)-inhibitors in the CM were quantified owing to their involvement in skin repair cascade. In addition, we report that the BMMSC-CM was also able to protect dermal fibroblasts against tert-Butyl hydro peroxide (tbOH) induced oxidative stress and ultra violet B (UV-B) radiation induced cell damage. Conclusion: Based on the data presented here, we propose that BMMSC-derived CM may have the potential to promote health and rejuvenation of the aging skin.

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“…In a pilot study by Fitzpatrick et al, application of mixture of growth factors on photodamaged skin showed clinical improvement and suggestion of collagen formation on histopathology [23]. Increase in epidermal thickness and increased fibroblast density in dermis in addition to clinical benefits of wrinkle reduction was seen in a study by Hussain et al [24].…”

Section: Discussionmentioning

confidence: 96%

A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population

Sachdev

Chullikana²,

Seetharam³

et al. 2017

JCDSA

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Introduction: The use of growth factors and cytokines in skin rejuvenation and reversal of photo ageing is a novel anti-ageing treatment. These factors provide a microenvironment that seems to favor tissue repair and regeneration. Methods: An open label, monocentric, single arm study to evaluate anti-ageing efficacy of conditioned medium obtained from adult human bonemarrow derived allogenic mesenchymal stromal cells (BMMSC) along with excipients formulated into a cosmetic serum, was conducted in 40 Indian female population aged 35 to 60 years, belonging to skin type IV -VI of Norwood Scale for a duration of 90 days. Parameters-fine lines, wrinkles, crow's feet, evenness of skin tone, skin firmness/laxity, hydration of skin, homogeneity of age spots, and visible pores were used to evaluate the anti-ageing and rejuvenating properties of the test product. Results and Discussion: Improvement was seen in majority of parameters starting from 15 -30 days. Product was safe and well tolerated as per the dermatologist and subjects' self-assessment.

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Reversal of photodamage with topical growth factors: a pilot study

Abstract: The application of a mixture of topical growth factors may stimulate the repair of facial photodamage resulting in new collagen formation, epidermal thickening and the clinical appearance of smoother skin with less visible wrinkling.

Cited by 126 publications

References 77 publications

Adipose Stem Cells as Alternatives for Bone Marrow Mesenchymal Stem Cells in Oral Ulcer Healing

Adipose Stem Cells as Alternatives for Bone Marrow Mesenchymal Stem Cells in Oral Ulcer Healing

Evaluation of the Secretome Profile and Functional Characteristics of Human Bone Marrow Mesenchymal Stromal Cells-Derived Conditioned Medium Suggest Potential for Skin Rejuvenation

A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population

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