Reversal of neuropathic pain is associated with corticostriatal functional reorganization after nerve repair in the spared nerve injury model

Bao, Qiyuan; Chang, Pei-Ching; Centeno, Maria Virginia; Farmer, Melissa A.; Baliki, Marwan N.; Procissi, Daniel; Zhang, Wei-Bin; Apkarian, A. Vania

doi:10.1097/j.pain.0000000000002590

Pain

2022

DOI: 10.1097/j.pain.0000000000002590

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Reversal of neuropathic pain is associated with corticostriatal functional reorganization after nerve repair in the spared nerve injury model

Qiyuan Bao

Pei-Ching Chang

Maria Virginia Centeno

et al.

Abstract: Supplemental Digital Content is Available in the Text.Nerve repair in the spared nerve injury model results in neuropathic pain recovery in a subset of rodents, which correlates with corticostriatal functional reorganization.

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2024

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Cited by 2 publications

References 36 publications

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Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVN^CRH Neurons via GABA_A Receptor β3 Subunits

Yu,

Zhu,

Peng

et al. 2024

Advanced Science

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Pain, a comorbidity of anxiety disorders, causes substantial clinical, social, and economic burdens. Emerging evidence suggests that propofol, the most commonly used general anesthetic, may regulate psychological disorders; however, its role in pain‐associated anxiety is not yet described. This study investigates the therapeutic potential of a single dose of propofol (100 mg kg−1) in alleviating pain‐associated anxiety and examines the underlying neural mechanisms. In acute and chronic pain models, propofol decreased anxiety‐like behaviors in the elevated plus maze (EPM) and open field (OF) tests. Propofol also reduced the serum levels of stress‐related hormones including corticosterone, corticotropin‐releasing hormone (CRH), and norepinephrine. Fiber photometry recordings indicated that the calcium signaling activity of CRH neurons in the paraventricular nucleus (PVNCRH) is reduced after propofol treatment. Interestingly, artificially activating PVNCRH neurons through chemogenetics interfered with the anxiety‐reducing effects of propofol. Electrophysiological recordings indicated that propofol decreases the activity of PVNCRH neurons by increasing spontaneous inhibitory postsynaptic currents (sIPSCs). Further, reducing the levels of γ‐aminobutyric acid type A receptor β3 (GABAAβ3) subunits in PVNCRH neurons diminished the anxiety‐relieving effects of propofol. In conclusion, this study provides a mechanistic and preclinical rationale to treat pain‐associated anxiety‐like behaviors using a single dose of propofol.

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Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVN^CRH Neurons via GABA_A Receptor β3 Subunits

Yu,

Zhu,

Peng

et al. 2024

Advanced Science

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Diclofenac sodium nanomedicine results in pain-relief and differential expression of the RNA transcriptome in the spinal cord of SNI rats

Zhang,

Yang,

Shuai

et al. 2024

International Journal of Pharmaceutics

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Reversal of neuropathic pain is associated with corticostriatal functional reorganization after nerve repair in the spared nerve injury model

Abstract: Supplemental Digital Content is Available in the Text.Nerve repair in the spared nerve injury model results in neuropathic pain recovery in a subset of rodents, which correlates with corticostriatal functional reorganization.

Cited by 2 publications

References 36 publications

Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVN^CRH Neurons via GABA_A Receptor β3 Subunits

Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVN^CRH Neurons via GABA_A Receptor β3 Subunits

Diclofenac sodium nanomedicine results in pain-relief and differential expression of the RNA transcriptome in the spinal cord of SNI rats

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Reversal of neuropathic pain is associated with corticostriatal functional reorganization after nerve repair in the spared nerve injury model

Abstract: Supplemental Digital Content is Available in the Text.Nerve repair in the spared nerve injury model results in neuropathic pain recovery in a subset of rodents, which correlates with corticostriatal functional reorganization.

Cited by 2 publications

References 36 publications

Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNCRH Neurons via GABAA Receptor β3 Subunits

Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNCRH Neurons via GABAA Receptor β3 Subunits

Diclofenac sodium nanomedicine results in pain-relief and differential expression of the RNA transcriptome in the spinal cord of SNI rats

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Product

Resources

About

Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVN^CRH Neurons via GABA_A Receptor β3 Subunits

Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVN^CRH Neurons via GABA_A Receptor β3 Subunits