Reversal of Neuroleptic-Induced Stupor by Procyclidin

Ungvari, Gabor S.; Pethö, B

doi:10.1055/s-0028-1094618

Cited by 9 publications

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“…In younger patients (< 50 years of age), 2 different kinds of behavioural reaction were noticed: the early (within days) reaction was clinical stupor, characterized by unresponsiveness and disturbed consciousness, followed by complete amnesia for the stupor ( Table 2). Women prevail in this group (cases 2, 4, 6). The late onset (within weeks) reaction is characterized by amnestic-confabulatory symptoms including memory-impairment and spatial disorientation ( Table 2).…”

Section: ( 8 )mentioning

confidence: 89%

Neuroleptic neurotoxicity; electro-clinical aspects

Sweden

1984

Acta Neurologica Scandinavica

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The clinical signs of psychotropic drug-induced neurotoxicity can be based on different neurochemical actions. Patients presenting with neurotoxic signs such as epileptic phenomena and altered states of consciousness are represented. Predisposing factors, EEG and clinical data and electro-clinical correlations are discussed and related to age and the drugs involved. It appears that in young patients, electro-clinical syndromes exist differentiating early from late-onset cerebral reactions. In the elderly, signs of neurotoxicity usually show an early onset and particular electro-clinical features. Finally pathogenetic considerations are reviewed.

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Section: ( 8 )mentioning

confidence: 89%

Neuroleptic neurotoxicity; electro-clinical aspects

Sweden

1984

Acta Neurologica Scandinavica

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Neuroleptic‐induced Catatonia After Abrupt Withdrawal of Amantadine During Neuroleptic Therapy

1986

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Catatonic reactions to high-potency neuroleptic drugs have been described in the literature. Our patient developed neuroleptic-induced catatonia (NIC) after abrupt withdrawal of amantadine, a dopaminergic agent that has been implicated in neuroleptic malignant syndrome (NMS) on its discontinuation. This case report adds support to the hypothesis that NIC and NMS are 2 syndromes on a continuum of dopamine blockade, each of which may be treated with or uncovered by amantadine therapy.

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Indikation und Differentialindikation der neuroleptischen Langzeitmedikation

Möller¹

1987

Neuroleptika Rückschau 1952–1986, Künftige Entwicklungen

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Reversal of Neuroleptic-Induced Stupor by Procyclidin

Cited by 9 publications

References 0 publications

Neuroleptic neurotoxicity; electro-clinical aspects

Neuroleptic neurotoxicity; electro-clinical aspects

Neuroleptic‐induced Catatonia After Abrupt Withdrawal of Amantadine During Neuroleptic Therapy

Indikation und Differentialindikation der neuroleptischen Langzeitmedikation

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