Reversal of NAFLD After VSG Is Independent of Weight-Loss but RYGB Offers More Efficacy When Maintained on a High-Fat Diet

Srivastava, Ankita; Stevenson, Matthew; Lee, Jenny; Hall, Charles E.; Palaia, Thomas; Zhao, Chaohui; Lau, Raymond; Brathwaite, Collin; Ragolia, Louis

doi:10.1007/s11695-022-06053-5

Cited by 4 publications

(1 citation statement)

References 75 publications

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“…This indicates that although weight loss per se is important in NAFLD treatment, other pathophysiological mechanisms play a role in fibrosis regression, which is also suggested by two other patient studies [ 36 , 37 ]. These clinical observations are supported by experimental animal studies demonstrating that improvement of glycemia [ 38 ] and reversal of NAFLD after RYGB occurs independent of weight loss [ 39 ]. We did not find factors associated with improvement of fibrosis.…”

Section: Discussionmentioning

confidence: 80%

The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores—An 11.6-Year Follow-Up Study

Sandvik

Aasarød

Johnsen

et al. 2022

JCM

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Severe obesity is a strong risk factor for non-alcoholic fatty liver disease (NAFLD). Roux-en-Y gastric bypass (RYGB) surgery effectively induces weight loss, but few studies have described the long-term effects of RYGB on NAFLD-related fibrosis. Data from 220 patients with severe obesity operated by RYGB in Central Norway were analysed. Variables incorporated in NAFLD Fibrosis Score (NFS), Fibrosis-4 (FIB-4) index and anthropometric data were collected before surgery and a mean of 11.6 years postoperatively. FIB-4 > 1.3 or NFS > 0.675 were used as cut-off values for advanced fibrosis. Proportions with advanced fibrosis decreased from 24% to 14% assessed by FIB-4 and from 8.6% to 2.3% using NFS, with resolution rates of advanced fibrosis of 42% and 73%, respectively. The shift towards lower fibrosis categories was significant (NFS p < 0.0001; FIB-4 p = 0.002). NFS decreased from −1.32 (IQR −2.33–−0.39) to −1.71 (IQR −2.49–−0.95, p < 0.001) 11.6 years after surgery, whereas FIB-4 did not change: 0.81 (IQR 0.59–1.25) to 0.89 (IQR 0.69–1.16, p = 0.556). There were weak correlations between change in fibrosis scores and weight loss. In conclusion, the majority of patients with advanced fibrosis at baseline had improvement after 11.6 years. Factors associated with reduction in fibrosis were not identified.

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Section: Discussionmentioning

confidence: 80%

The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores—An 11.6-Year Follow-Up Study

Sandvik

Aasarød

Johnsen

et al. 2022

JCM

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The Effect of Diet Composition on the Post-operative Outcomes of Roux-en-Y Gastric Bypass in Mice

Stevenson,

Srivastava,

Nacher

et al. 2024

OBES SURG

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Frequency stability of new energy power systems based on VSG adaptive energy storage coordinated control strategy

Cheng,

Yan,

Zhang

et al. 2024

Energy Inform

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A self-adaptive energy storage coordination control strategy based on virtual synchronous machine technology was studied and designed to address the oscillation problem caused by new energy units. By simulating the characteristics of synchronous generators, the inertia level of the new energy power system was enhanced, and frequency stability optimization was achieved. This strategy is integrated with the frequency response model of the new energy power system to improve the system's frequency regulation capability and achieve more stable and efficient operation. From the results, the damping of the system increased, the oscillation frequency decreased after a duration of about 15 s, and the system stability improved by 76.09%. The proposed strategy based on virtual synchronous generator adaptive energy storage coordination control strategy was improved by 83.25%. In addition, the proposed strategy has improved stability indicators and system completion efficiency by 40.57% and 22.21% respectively, both of which are better than the comparative strategies. As a result, this strategy significantly enhances the frequency regulation capability of the system, which has a positive effect on achieving efficient operation of the new energy power system and maintaining the stability of the power system.

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Reversal of NAFLD After VSG Is Independent of Weight-Loss but RYGB Offers More Efficacy When Maintained on a High-Fat Diet

Cited by 4 publications

References 75 publications

The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores—An 11.6-Year Follow-Up Study

The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores—An 11.6-Year Follow-Up Study

The Effect of Diet Composition on the Post-operative Outcomes of Roux-en-Y Gastric Bypass in Mice

Frequency stability of new energy power systems based on VSG adaptive energy storage coordinated control strategy

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