Reversal of Metabolic Disorder Through the Restoration of Gut Microbiota

Upadhyay, Prabhat; Kalra, Diya; Gupta, Sarika; Mishra, Sunil Kumar

doi:10.1007/978-981-19-4530-4_11

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…We studied this traditional concept with a modern approach, where we procured the material from different geographical locations, to get a polyphenols-rich formulation. UPLCMS analysis con rmed presence of several secondary metabolites (Table 1) those have previously been reported for memory improvement, and gut modulation [10]. Next, we design a detailed study in murine model of AD to provide scienti c evidence to our traditional knowledge by observing the impact of our formulation in reducing in ammation, antioxidant activity, and the neurogenesis process against neurodegeneration.…”

Section: Discussionmentioning

confidence: 86%

Bidirectional effect of Triphala on modulating Gut-brain axis to improve cognition in the Murine Model of Alzheimer’s disease

Upadhyay

Tyagi

Agrawal

et al. 2023

Preprint

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Background The emerging role of gut microbiota and their metabolites in the modulation of the gut-brain axis has received much attention as a new hope for the treatment of hard-to-treat chronic neurodegenerative diseases like Alzheimer’s Disease. The naturally occurring polyphenols can restore the gut-brain axis by modulating gut microbiota and brain neurotransmitters. However, the mechanism of action remained unclear. The Indian traditional medicine Triphala, a rich source of polyphenols, has been used on humans based on Prakriti or disease conditions for many years. Methods: In this study, the dual mode (morning and evening) action of Triphala was used to provide scientific evidence of its superior preventive and therapeutic efficacy in C57BL/6 and 5xFAD, APP/PS1 transgenic mouse model of Alzheimer’s disease. For behavior analysis, used the Morris water model and Y maze model to assess spatial memory and exploratory behavior. The blood serum and brain lysate were used to evaluate the inflammatory activity and oxidative parameters in the mice. The gut microbiome analysis was done by 16srRNA analysis from mice feces after 60 days of treatment. Results We observed that Triphala treatment has significantly improved cognitive function, by modulating the APP pathway, reducing inflammation, oxidative stress, and restoring the gut-brain axis by increasing the gut microbiota phyla of Bacteroides, Proteobacteria, Actinobacteria, etc., involved in maintaining the gut homeostasis. Conclusions Our study paved a new path for using dual modes of Triphala one or in combination to treat incurable AD.

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Section: Discussionmentioning

confidence: 86%

Bidirectional effect of Triphala on modulating Gut-brain axis to improve cognition in the Murine Model of Alzheimer’s disease

Upadhyay

Tyagi

Agrawal

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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Bidirectional Effect of Triphala on Modulating Gut‐Brain Axis to Improve Cognition in the Murine Model of Alzheimer's Disease

Upadhyay,

Tyagi,

Agrawal

et al. 2023

Molecular Nutrition Food Res

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ScopeThe emerging role of gut microbiota and their metabolites in the modulation of the gut‐brain axis has received much attention as a new hope for the treatment of hard‐to‐treat chronic neurodegenerative diseases like Alzheimer's disease. The naturally occurring polyphenols can restore the gut‐brain axis by modulating gut microbiota and brain neurotransmitters. The Indian traditional medicine Triphala, a rich source of polyphenols, has been used on humans based on Prakriti or disease conditions for many years.Methods and resultsIn this study, the dual mode (morning and evening) action of Triphala is used to provide scientific evidence of its superior preventive and therapeutic efficacy in C57BL/6 and 5xFAD, APP/PS1 transgenic mouse model of Alzheimer's disease. The study observes that Triphala treatment has significantly improved cognitive function, by modulating the APP pathway, reducing inflammation, and restoring the gut‐brain axis by increasing the gut microbiota phyla of Bacteroides, Proteobacteria, Actinobacteria, etc., involved in maintaining the gut homeostasis.ConclusionsThe study paves a new path for using dual modes of Triphala alone or in combination to treat incurable AD.

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Reversal of Metabolic Disorder Through the Restoration of Gut Microbiota

Cited by 2 publications

References 39 publications

Bidirectional effect of Triphala on modulating Gut-brain axis to improve cognition in the Murine Model of Alzheimer’s disease

Bidirectional effect of Triphala on modulating Gut-brain axis to improve cognition in the Murine Model of Alzheimer’s disease

Bidirectional Effect of Triphala on Modulating Gut‐Brain Axis to Improve Cognition in the Murine Model of Alzheimer's Disease

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