Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor

Galamb, Orsolya; Spisák, Sándor; Sípos, Ferenc; Tóth, Kinga; Solymosi, Norbert; Wichmann, Barnabás; Krenács, Tibor; Valcz, Gábor; Tulassay, Zsolt; Molnár, Béla

doi:10.1038/sj.bjc.6605515

Cited by 66 publications

(72 citation statements)

References 38 publications

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“…In gastric cancer, KIAA1119 is a potential prognostic and lymph node metastatic marker30. Moreover, KIAA1199 is highly expressed in adenoma, implying the potential application of KIAA1199 as a biomarker for early stages of cancer38.…”

Section: Discussionmentioning

confidence: 99%

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia

Jun

Srivastava

et al. 2016

Sci Rep

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Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific symptoms. Thus, developing novel approaches for detecting pancreatic cancer at an early stage is imperative. Our in silico and immunohistochemical analyses showed that KIAA1199 is specifically expressed in human pancreatic cancer cells and pancreatic intraepithelial neoplasia, the early lesion of pancreatic cancer, in a genetically engineered mouse model and in human patient samples. We also detected secreted KIAA1199 protein in blood samples obtained from pancreatic cancer mouse models, but not in normal mice. Furthermore, we found that assessing KIAA1199 autoantibody increased the sensitivity of detecting pancreatic cancer. These results indicate the potential benefits of using KIAA1199 as a biomarker for early-stage pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia

Jun

Srivastava

et al. 2016

Sci Rep

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“…Regulation of cytokinesis may be the one conserved function of the Cdc14 phosphatases. Although overexpression of CDKN3 has been associated with inhibition of cell proliferation in colon cancer cell lines (Galamb et al 2010), it has been found to be overexpressed in breast, prostate, and lung cancers (MacDermed et al 2010;Julien et al 2011;Taylor et al 2010). In the previous report of the association of CDKN3 with cervical cancer, CDKN3 was shown to behave as an oncogene (Espinosa et al 2013).…”

Section: Mitosis Is the Main Phase Of The Cell Cycle Altered In Cervimentioning

confidence: 98%

Mitosis Targets as Biomarkers in Cervical Cancer

Berúmen¹,

Espinosa²,

Medina³

et al. 2014

Biomarkers in Cancer

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The effectiveness of a preventive human papillomavirus (HPV) vaccination for reducing the cervical cancer (CC) burden will likely not be known for 30 years. Current screening methods for detecting highgrade cervical intraepithelial neoplasias (CIN2/3) and CC (CIN2+) have low sensitivity (Pap test) or low specificity (HPV tests). Improved procedures for CC screening and treatment are therefore required. Based on comparisons with healthy cervical epithelium, the genes most upregulated and enriched in CC are those involved in mitosis. Some of these upregulated genes might be good candidates for CC screening or survival markers or as potential therapeutic targets. In this chapter, we analyze the benefits and limitations of current methods used for early CC detection, the evidence that demonstrates that the most enriched genes in CC are those involved in mitosis, the mechanism that regulates mitosis and its relationship with HPV, and our experimental evidence suggesting that some mitosis genes might be good markers for screening and survival in CC. In addition, we discuss the need to develop less expensive and more efficient methods that can be automated for large-scale application in poor and developing countries. We also discuss the potential use of the markers for other types of cancers and as potential therapeutic targets.

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“…Total RNA extraction, labeling, hybridization, quantity and quality controls were done as described in details in (Galamb et al 2010). …”

Section: Avymetrix Microarray Analysismentioning

confidence: 99%

Antler development and coupled osteoporosis in the skeleton of red deer Cervus elaphus: expression dynamics for regulatory and effector genes

et al. 2010

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Antlers of deer display the fastest and most robust bone development in the animal kingdom. Deposition of the minerals in the cartilage preceding ossification is a specific feature of the developing antler. We have cloned 28 genes which are upregulated in the cartilaginous section (called mineralized cartilage) of the developing ("velvet") antler of red deer stags, compared to their levels in the fetal cartilage. Fifteen of these genes were further characterized by their expression pattern along the tissue zones (i.e., antler mesenchyme, precartilage, cartilage, bone), and by in situ hybridization of the gene activities at the cellular level. Expression dynamics of genes col1A1, col1A2, col3A1, ibsp, mgp, sparc, runx2, and osteocalcin were monitored and compared in the ossified part of the velvet antler and in the skeleton (in ribs and vertebrae). Expression levels of these genes in the ossified part of the velvet antler exceeded the skeletal levels 10-30-fold or more. Gene expression and comparative sequence analyses of cDNAs and the cognate 5' cis-regulatory regions in deer, cattle, and human suggested that the genes runx2 and osx have a master regulatory role. GC-MS metabolite analyses of glucose, phosphate, ethanolamine-phosphate, and hydroxyproline utilizations confirmed the high activity of mineralization genes in governing the flow of the minerals from the skeleton to the antler bone. Gene expression patterns and quantitative metabolite data for the robust bone development in the antler are discussed in an integrated manner. We also discuss the potential implication of our findings on the deer genes in human osteoporosis research.

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Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor

Cited by 66 publications

References 38 publications

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia

Mitosis Targets as Biomarkers in Cervical Cancer

Antler development and coupled osteoporosis in the skeleton of red deer Cervus elaphus: expression dynamics for regulatory and effector genes

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