Reversal of deltamethrin-induced oxidative damage in rat neural tissues by turmeric-diet: Fourier transform-infrared and biochemical investigation

Shivanoor, Shiddappa Mallappa; David, Muniswamy

doi:10.1016/j.jobaz.2016.10.003

Cited by 10 publications

(4 citation statements)

References 79 publications

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“…Further, changes in CH 2 asymmetric and CH 2 symmetric stretching of lipids also depicted conformational disorder and alteration in lipid acyl chain flexibility. The alteration in olefinic =CH band area value at 3014 cm −1 indicates the change in the number of unsaturated lipids [ 78 ]. The study observed that a decrease in the peak of amide I and II were consistent with the decline in amide A band area values.…”

Section: Discussionmentioning

confidence: 99%

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

et al. 2021

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Oxidative stress-mediated tissue damage is primarily involved in hepatic injuries and dysfunctioning. Natural antioxidants have been shown to exert hepatoprotective, anti-inflammatory and antiapoptotic properties. The present study evaluated the effect of N-acetylcysteine (NAC) against monocrotophos (MCP) exposure-induced toxicity in the rat liver. Albino Wistar rats were divided into four groups: (1) control, (2) NAC-treated, (3) MCP-exposure, (4) NAC and MCP-coexposure group. The dose of MCP (0.9 mg/kg b.wt) and NAC (200 mg/kg b.wt) were administered orally for 28 days. Exposure to MCP caused a significant increase in lipid peroxidation, protein oxidation and decreased glutathione content along with the depletion of antioxidant enzyme activities. Further MCP exposure increased pro-inflammatory cytokines levels and upregulated Bax and Caspase-3 expressions. MCP exposure also caused an array of structural alternations in liver tissue, as depicted by the histological and electron microscopic analysis. Thepretreatment of NAC improved glutathione content, restored antioxidant enzyme activities, prevented oxidation of lipids and proteins, decreased pro-inflammatory cytokines levels and normalized apoptotic protein expression. Treatment of NAC also prevented histological and ultrastructural alternations. Thus, the study represents the therapeutic efficacy and antioxidant potential of NAC against MCP exposure in the rat liver.

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Section: Discussionmentioning

confidence: 99%

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

et al. 2021

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“…The spectra were analyzed using Origin 8.5 software. The absorption bands for lipids, proteins, phospholipids and nucleic acids in Table 4 were defined according to the literature [ 30 , 65 , 66 ].…”

Section: Methodsmentioning

confidence: 99%

Alleviation of Memory Deficit by Bergenin via the Regulation of Reelin and Nrf-2/NF-κB Pathway in Transgenic Mouse Model

Shal

Khan

et al. 2021

IJMS

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The present study aims to determine the neuroprotective effect of Bergenin against spatial memory deficit associated with neurodegeneration. Preliminarily, the protective effect of Bergenin was observed against H2O2-induced oxidative stress in HT-22 and PC-12 cells. Further studies were performed in 5xFAD Tg mouse model by administering Bergenin (1, 30 and 60 mg/kg; orally), whereas Bergenin (60 mg/kg) significantly attenuated the memory deficit observed in the Y-maze and Morris water maze (MWM) test. Fourier transform-infrared (FT-IR) spectroscopy displayed restoration of lipids, proteins and their derivatives compared to the 5xFAD Tg mice group. The differential scanning calorimeter (DSC) suggested an absence of amyloid beta (Aβ) aggregation in Bergenin-treated mice. The immunohistochemistry (IHC) analysis suggested the neuroprotective effect of Bergenin by increasing Reelin signaling (Reelin/Dab-1) and attenuated Aβ (1–42) aggregation in hippocampal regions of mouse brains. Furthermore, IHC and western blot results suggested antioxidant (Keap-1/Nrf-2/HO-1), anti-inflammatory (TLR-4/NF-kB) and anti-apoptotic (Bcl-2/Bax/Caspase-3) effect of Bergenin. Moreover, a decrease in Annexin V/PI-stained hippocampal cells suggested its effect against neurodegeneration. The histopathological changes were reversed significantly by Bergenin. In addition, a remarkable increase in antioxidant level with suppression of pro-inflammatory cytokines, oxidative stress and nitric oxide production were observed in specific regions of the mouse brains.

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“…9,10 Hence, monitoring the residual amounts of DLM and FV in the environment is highly demanded in analytical and environmental sciences. In view of this, several analytical techniques have been reported for the detection of both DLM and FV, including gas chromatography, 11 high-performance liquid chromatography, 12 mass spectrometry, 13 immunoassay-based methods, 14 and surface-enhanced Raman spectroscopy. 15 However, these techniques have certain limitations, such as high sample volume, requirement of skilled technicians, time, difficulty, complicated sample preparation, and difficulty to apply for on-site analysis.…”

Section: Introductionmentioning

confidence: 99%

Deltamethrin and fenvalerate in vegetables and rice

Vadia,

Johny,

Malek

et al. 2023

Sustainable Food Technol.

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Reversal of deltamethrin-induced oxidative damage in rat neural tissues by turmeric-diet: Fourier transform-infrared and biochemical investigation

Cited by 10 publications

References 79 publications

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

Alleviation of Memory Deficit by Bergenin via the Regulation of Reelin and Nrf-2/NF-κB Pathway in Transgenic Mouse Model

Deltamethrin and fenvalerate in vegetables and rice

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