Reversal of Decreased Human Adipose Tissue Lipoprotein Lipase and Hypertriglyceridemia after Treatment of Hypothyroidism

Pykälistö, Olavi; Goldberg, Andrew P.; Brunzell, John D.

doi:10.1210/jcem-43-3-591

Cited by 70 publications

(30 citation statements)

References 20 publications

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“…TG level and TG lipases. A significant correlation was found between the changes in extrahepatic LPL as measured by antibody inhibition and the increase in plasma TG (r8 = -0.600, P < 0.05, n = 13) or VLDL-TG (r, = -0.626, P < 0.05, n = 13 (35) TG (8), and lipolysis of endogenous TG man as compared to normal levels in uremic (36) trin infusion (9), do not reveal impaired or hypothyroid (37,38) rats. It is clear from the 1 during estrogen (7,9) or oral contra-present studies, however, that premenopausal 8) therapy.…”

Section: Resultsmentioning

confidence: 88%

Effect of estrogen on post-heparin lipolytic activity. Selective decline in hepatic triglyceride lipase.

Applebaum¹,

Goldberg²,

Pykälistö³

et al. 1977

J. Clin. Invest.

200

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A B S T R A C T The rise in plasma triglyceride (TG) levels associated with estrogen administration has been thought to arise from impaired clearance because of the uniform suppression of post-heparin lipolytic activity (PHLA). Recently PHLA has been shown to consist of two activities: hepatic TG lipase and extrahepatic lipoprotein lipase (LPL). To determine whether estrogen might induce a selective decline in one of these activities, both hepatic TG lipase and extrahepatic LPL were measured in postheparin plasma from 13 normal women before and after 2 wk of treatment with ethinyl estradiol (1 ,ug/kg per day). Hepatic TG lipase and extrahepatic LPL were determined by two techniques: (a) separation by heparin-Sepharose column chromatography, and (b) selective inhibition with specific antibodies to post-heparin hepatic TG lipase and milk LPL. Estrogen uniformly depressed hepatic TG lipase as measured by affinity column (-68±12%, mean±SD, P < 0.001) or antibody inhibition (-63±11%, P < 0.001). Extrahepatic LPL was not significantly changed by affinity column (-22±40%) or antibody inhibition (-3+42%). Direct measurement of adipose tissue LPL from buttock fat biopsies also showed no systematic change in the activated form of LPL measured as heparin-elutable LPL (+64+164%) or in the tissue form of LPL measured in extracts of acetone-ether powders (+21±77%). The change in hepatic TG lipase correlated with the change in PHLA (r = 0.969, P < 0.01). However, neither the change in PHLA nor hepatic TG lipase correlated with the in-

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Section: Resultsmentioning

confidence: 88%

Effect of estrogen on post-heparin lipolytic activity. Selective decline in hepatic triglyceride lipase.

Applebaum¹,

Goldberg²,

Pykälistö³

et al. 1977

J. Clin. Invest.

200

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“…Thyroid hormone decreases serum cholesterol concentration by the removal of cholesterol from the liver via the increased LDL receptors [17,18] and serum TG concentration by enhancing lipoprotein lipase and hepatic lipase activities [19][20][21]. Thus, a higher population of hypothyroid subjects had a higher incidence of dyslipidemia [22].…”

Section: Discussionmentioning

confidence: 99%

Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia

et al. 2011

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abstract. Hypercholesterolemia is one of the most representative disorders of the common diseases. To evaluate the prevalence of hypothyroidism in the population of adult hypercholesterolemia, we prospectively examined the thyroid function in patients with untreated or treated hypercholesterolemia as a multi-center survey. Subjects were the patients who were treated with some antilipemic agents or the untreated patients whose total cholesterol (TC) was over 220 mg/dL and/or LDL-cholesterol (LDL-C) over 140 mg/dL. Among 737 cases recruited, 725 cases (300 males and 425 females) participated in the survey including the thyroid function test. The patient's backgrounds include hypertension (51%), diabetes mellitus (49%), fatty liver (17%), smoking (15%), and habitual drinking (10%). The 72% of the patients were treated with some antilipemic agents and the mean values of TC, LDL-C, triglyceride (TG), HDL-cholesterol (HDL-C), and LDL-C/HDL-C ratio were 204.5 mg/dL, 119.6 mg/dL, 144.4 mg/dL, 60.7 mg/dL and 2.25, respectively. The primary hypothyroidism was seen in 27 cases (3.7%) (11 males, 16 females) with subclinical hypothyroidism in 17 cases (2.4%) and overt hypothyroidism in 10 cases (1.4%). The central hypothyroidism was seen in 4 cases (0.6%). The prevalence of hypothyroidism was 4.3% in patients with hypercholesterolemia. Taking account of the large number of patients with dyslipidemia and importance of avoiding unnecessary administration and associated adverse effects, evaluation of the thyroid function could be warranted in patients with dyslipidemia although cost-benefit issues waits further investigation.Key words: Hypercholesterolemia, Dyslipidemia, Subclinical hypothyroidism strongly related to atherosclerotic cardiovascular disease. Recently, new therapeutic reagents such as fibrates and statins have been created and primary dyslipidemia is effectively treated with these reagents [1]. However, they are not low priced and may induce rare but serious side effects such as rhabdomyolysis [1]. Hypothyroidism induces secondary hypercholesterolemia that increases the incidence of atherosclerotic cardiovascular events [2], and replacement of low-

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“…BM2250 fully automated chemical analyzer (Nihondenshi Ltd., Tokyo, Japan) LDL-C is a major therapeutic target in the treatment of dyslipidemia 6) . While there is controversy regarding serum triglyceride (TG) concentrations in patients with hypothyroidism 7,8) , serum LDL-C and TG-rich lipoproteins (TRL), including chylomicrons (CM), very-low-density lipoproteins (VLDL), and their remnant lipoproteins, were reported to be increased in patients with hypothyroidism 9,10) . Therefore, increased LDL-C and remnant lipoproteins in patients with OH are clinically important from the point of CVD prevention 11) .…”

Section: Laboratory Measurementsmentioning

confidence: 99%

Thyroid Function Influences Serum Apolipoprotein B-48 Levels in Patients with Thyroid Disease

Mugii

Hanada

Okubo

et al. 2012

JAT

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Aim: Apolipoprotein B-48 (apoB-48) is a major apolipoprotein of intestine-derived chylomicrons (CM) and CM remnants (CMR).Clinically overt hypothyroidism (OH) has been associated with premature and accelerated coronary atherosclerosis. To clarify the clinical significance of apoB-48 measurement in patients with thyroid disease, we investigated the correlations between the serum apoB-48 level and thyroid hormones. Methods: From outpatients of Osaka University Hospital, patients with OH, subjects with subclinical hypothyroidism (SH) and subjects with normal thyroid function were collected and analyzed by measuring serum TSH, FT4 and FT3 levels. Serum apoB-48 levels were measured by a chemiluminescence enzyme immunoassay and the correlations with thyroid hormone levels or lipid profiles were assessed. These levels were compared among subjects with OH, SH and healthy controls. Results: Serum apoB-48 level was correlated with TSH, total cholesterol (TC) and triglycerides (TG), but negatively with FT4 and FT3 level. LDL-C and HDL-C levels were not correlated with serum apoB-48 levels. Serum apoB-48 in patients with OH (7.4±5.9 μg/mL) was significantly higher than in those with hyperthyroidism (5.1±3.5 μg/mL; p＜0.01) and normal subjects (4.7±3.7 μg/mL; p＜0.01), but decreased after levo-thyroxine replacement. ApoB-48, TG and TSH were significantly higher in SH subjects than normal subjects, suggesting that serum apoB-48 level depends on the thyroid function status, similar to TC, LDL-C and TG. Conclusion: Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state.

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Reversal of Decreased Human Adipose Tissue Lipoprotein Lipase and Hypertriglyceridemia after Treatment of Hypothyroidism

Cited by 70 publications

References 20 publications

Effect of estrogen on post-heparin lipolytic activity. Selective decline in hepatic triglyceride lipase.

Effect of estrogen on post-heparin lipolytic activity. Selective decline in hepatic triglyceride lipase.

Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia

Thyroid Function Influences Serum Apolipoprotein B-48 Levels in Patients with Thyroid Disease

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