Reversal of Atrial Remodeling after Cardioversion of Persistent Atrial Fibrillation Measured with Magnetocardiography

Lehto, Mika; Jurkko, Raija; Parikka, Hannu; Mäntynen, Ville; Väänänen, Heikki; Montonen, Juha; Voipio‐Pulkki, Liisa‐Maria; Toivonen, Lauri; Laine, Mika

doi:10.1111/j.1540-8159.2008.02205.x

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…26 The association of the ACE DD genotype with a higher rate of recurring AF found in this study supports this concept. Similarly, a very recent study demonstrated that higher transforming growth factor-β1 levels are associated with AF recurrence after catheter ablation.…”

Section: Ace Insertion/deletion Polymorphism and Functionality In Af supporting

confidence: 78%

Genetic ACE I/D Polymorphism and Recurrence of Atrial Fibrillation After Catheter Ablation

Ueberham

Bollmann

Shoemaker

et al. 2013

Circ: Arrhythmia and Electrophysiology

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Background-The angiotensin-converting enzyme (ACE) deletion allele, ACE D, is associated with increased cardiac ACE activity, cardiac fibrosis, and adverse outcomes in cardiovascular disease and has been linked with failure of antiatrial fibrillation (anti-AF) drug treatment. This study tested the hypothesis that the ACE gene insertion/deletion polymorphism associates with AF recurrence after catheter ablation. Methods and Results-In 238 consecutive patients (69% male; mean age, 58±11 years) undergoing catheter ablation of paroxysmal (59%) or persistent (41%) AF, the ACE insertion/deletion polymorphism was genotyped using polymerase chain reaction. After a blanking period of 3 months, AF recurrence (defined as any atrial arrhythmia lasting ≥30 s) was detected using serial 7-day Holter ECG recordings after 3, 6, and 12 months. AF recurrence was observed in 39% and was associated with persistent AF,

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Section: Ace Insertion/deletion Polymorphism and Functionality In Af supporting

confidence: 78%

Genetic ACE I/D Polymorphism and Recurrence of Atrial Fibrillation After Catheter Ablation

Ueberham

Bollmann

Shoemaker

et al. 2013

Circ: Arrhythmia and Electrophysiology

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“…Indeed, although experience is still limited to only few institution, contactless MCG is one of the most promising technology for non‐invasive cardiac electro‐anatomical imaging and accurate localization of arrhythmogenic substrates (Brisinda, Venuti, Sorbo, & Fenici, ; Fenici & Brisinda, ; Fenici, Brisinda, Venuti, & Sorbo, ; Kwong, Leithäuser, Park, & Yu, ). Several studies, all carried out in magnetically shielded rooms, have demonstrated the usefulness of MCG to study AF (Jurkko et al, , ; Kim & Ahn, ; Kim, Kim, Lee, & Ahn, ; Koskinen et al, ; Lehto et al, ; Lim et al, ; Mäntynen et al, ; Nakai et al, ; Sato et al, ; Yamada & Yamaguchi, ; Yamada, Tsukada, Miyashita, Kuga, & Yamaguchi, ; Yoshida et al, ). The reproducibility of automatically measured terminal high‐frequency component of signal averaged atrial magnetic signals was evaluated in PAF patients compared with controls (Koskinen et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Among different analytic approaches used to evaluate the predictive value of MCG for AF occurrence and recurrence, pseudo‐current reconstruction was reported as sensitive method to non‐invasively differentiate inter‐atrial conduction patterns in normal subjects as well as in patients with PAF (Jurkko et al, ; Koskinen et al, ; Lehto et al, ; Mäntynen et al, ; Sato et al, ). Delayed atrial conduction along in the Bachmann’s bundle (BB), prevalence of inter‐atrial conduction at the fossa ovalis (FO), or multisite inter‐atrial conduction pattern were associated with PAF (Jurkko et al, ).…”

Section: Introductionmentioning

confidence: 99%

Predictive value of unshielded magnetocardiographic mapping to differentiate atrial fibrillation patients from healthy subjects

Guida

Sorbo

Fenici

et al. 2018

Noninvasive Electrocardiol

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“…Thus altered and alternative conduction pathways may contribute to pathogenesis of lone AF [59]. Interestingly, in patients with persistent AF after cardioversion, MCG but not signal-averaged ECG or echocardiography identified electrophysiological alterations with incomplete recovery after 1 month in stable sinus rhythm [60].…”

Section: Rozkład Prądów Nasierdziowych U Pacjenta Z Ciasnym Zwężenimentioning

confidence: 99%

Special article Magnetocardiography in clinical cardiology. Status quo and future applications

Leithäuser¹,

Jung²,

Park³

2011

pwki

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215Magnetocardiography in clinical cardiology. Status quo and future applications Magnetokardiografia w kardiologii klinicznej. Stan obecny i przyszłe zastosowania B Bo or ri is s L Le ei it th hä äu us se er r 1 1 , , F Fr ri ie ed dr ri ic ch h J Ju un ng g 2 2 , , J Ja ai i--W Wu un n P Pa ar rk k Special article/Artykuł specjalny A b s t r a c tMagnetocardiography (MCG) is a non-contact, non-invasive technique for the assessment of electromagnetic activity of the human heart. Theoretical considerations and comparative studies indicate different information content between MCG and electrocardiography (ECG). Although many questions about cardiac pathophysiology and electrophysiology can be answered by MCG studies, measurement of biomagnetism is still only marginally recognized as a valuable tool. Although MCG instrumentation (SQUIDs, MSR) and operation (liquid helium) are expensive and not available at the bedside, the gain of information drawn from the cardiac magnetic field is worth the effort. The MCG has superior sensitivity for ischaemic myocardium both at rest and under stress. Therefore, it may change one's ideas of decision making about invasive procedures. Compared to scintigraphy, which is a cumbersome method with the need of radioactivity exposure to the patient, MCG is as easy as bicycle ergometry but with higher sensitivity. In terms of risk stratification for sudden cardiac death, it seems to be possible that MCG in the future will provide additional information as to which patient will not benefit from prophylactic defibrillator implantation. However, appropriate clinical studies are lacking. Most interestingly, MCG appears to be practical and informative in the diagnosis of cardiac arrhythmias, and has sufficient spatial accuracy necessary for clinical purposes. It seems realistic that MCG-based localization of arrhythmogenic spots may guide the operator's ablation catheter, e.g. in patients with relapsing AF after a first successful ablation procedure. There is enough room for fantasy which question in clinical cardiology remains to be answered by MCG. K Ke ey y w wo or rd ds s: : magnetocardiography, coronary heart disease, ischaemia, risk stratification, arrhythmia, atrial fibrillation S t r e s z c z e n i e Magnetokardiografia (ang. magnetocardiography, MCG) jest bezkontaktową, nieinwazyjną metodą pomiaru pola magnetycznego ludzkiego serca. Założenia teoretyczne oraz badania porównawcze wskazują, że MCG i EKG dostarczają odmiennych informacji. Pomiar pola magnetycznego jest nadal w niewielkim stopniu uważany za wartościowe narzędzie, pomimo że badania MCG mogą udzielić odpowiedzi na wiele pytań dotyczących patofizjologii serca i elektrofizjologii. Chociaż oprzyrządowanie konieczne do MCG (SQUIDs, MSR) i jego obsłu-ga (ciekły hel) są drogie i nie są dostępne jako badania przyłóżkowe, to informacja uzyskiwana z badań pola magnetycznego serca jest warta tych wysiłków. Magnetokardiografia charakteryzuje się większą czułością w wykrywaniu niedokrwienia miokardium zarówno w warunkach spoczynkow...

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Reversal of Atrial Remodeling after Cardioversion of Persistent Atrial Fibrillation Measured with Magnetocardiography

Abstract: Magnetocardiographically detected atrial electrophysiologic alterations in persistent AF diminish rapidly although incompletely during maintained SR after CV. This might be related to the known early high and late lower, but still existent tendency to AF relapses.

Cited by 11 publications

References 23 publications

Genetic ACE I/D Polymorphism and Recurrence of Atrial Fibrillation After Catheter Ablation

Genetic ACE I/D Polymorphism and Recurrence of Atrial Fibrillation After Catheter Ablation

Predictive value of unshielded magnetocardiographic mapping to differentiate atrial fibrillation patients from healthy subjects

Special article Magnetocardiography in clinical cardiology. Status quo and future applications

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