Reversal of Apoptotic Resistance by Lycium barbarum Glycopeptide 3 in Aged T Cells

A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji)

“…LBP increased the apoptotic rate of T cells from aged mice and showed a similar DNA ladder pattern to that in young T cells. The reversal of apoptotic resistance was involved in down-regulating the expression of Bcl-2 and FLIP, and up-regulating the expression of FasL (Yuan, Deng, Chen, Li, & He, 2008).…”

Lycium Barbarum and Human Health

“…Flow cytometry assays revealed that L. barbarum polysaccharide enhanced the proliferation of murine splenic lymphocyte. L. barbarum glycopeptide 3 reverses apoptotic resistance of aged T cells by modulating the expression of apoptosis-related molecules (Yuan et al 2008). MTT assays demonstrated that LBP significantly promoted proliferation of murine splenic lymphocytes, whereas LBP plus Con A combination also enhanced the lymphocyte proliferation at a high concentration.…”

“…The L. barbarum phytochemical diversity includes polysaccharides, carotenoids, flavonoids, alkaloids , peptides (Yuan et al 2008), sterols (Park et al 2012), organic acids Dong et al 2013), essential oils , glycolipids , polyphenols (Dong et al 2011) and so on Wang et al 2010a). Presently, only polysaccharides and polysaccharide-protein complex have been reported to possess immune regulation activity.…”

Lycium Barbarum: A Traditional Chinese Herb and A Promising Anti-Aging Agent

“…The reversal of apoptotic resistance involved down-regulation of the expression of Bcl-2 and FLIP, and the up-regulation of Fas ligand (FasL). These results demonstrated that LBGP3 reverses apoptotic resistance of aged T cells by modulating the expression of apoptosis-related molecules [ 35 ]. Another study observed the protective effects of LBPs on focal cerebral ischemic reperfusion injury in mice.…”