Reversal of Alcohol-Induced Learning Deficits in the Young Adult in a Model of Fetal Alcohol Syndrome

Incerti, Maddalena; Vink, Joy; Roberson, Robin; Wood, L M; Abebe, Daniel; Spong, Catherine Y.

doi:10.1097/aog.0b013e3181cb59da

Cited by 29 publications

(22 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mice were then gavaged with two neuroprotective peptides (D-NAP + D-SAL) between postnatal days 67 and 76 and their performance in the Morris water maze task was assessed. In contrast to recent results (Incerti et al, 2010), injection of ethanol during gestational day 8 did not produce significant alterations in spatial learning and memory. In contrast, injection during postnatal day 7 did produce significant alterations in the Morris water maze test.…”

Section: Fast Data Presentationscontrasting

confidence: 99%

Proceedings of the 2014 Annual Meeting of the Fetal Alcohol Spectrum Disorders Study Group

Reynolds

Valenzuela

Medina

et al. 2015

Alcohol

View full text Add to dashboard Cite

The 2014 Fetal Alcohol Spectrum Disorders Study Group (FASDSG) meeting focused on the dual themes of the risks associated with low to moderate alcohol exposure during pregnancy and knowledge translation practices to enhance the impact of scientific research. The meeting theme was titled “Low drinking versus no drinking: Matching science with policy and public perception”. Despite decades of basic science and clinical evidence that has documented the risks associated with prenatal alcohol exposure, there still exists confusion and uncertainty on the part of health professionals and the public regarding the question of whether or not there is a “safe” level of alcohol consumption during pregnancy. The first keynote presentation reviewed the data obtained from large-scale epidemiological studies that have attempted to address the question of relative risk associated with low to moderate alcohol exposure during pregnancy. This presentation was followed by an expert panel discussion of the state of scientific evidence obtained from clinical and basic science investigations concerning this question, and strategies for moving research evidence into policy and practice. The second keynote presentation presented a framework for knowledge translation and mobilization to move research discoveries toward implementation. The conference also featured updates by government agencies, FASt data talks that highlighted new and innovative findings in FASD research, and award presentations, including a lifetime achievement award presented to Dr. Kenneth Warren to acknowledge his longstanding support for FASD research. A highlight of the meeting was the presentation of the 2014 Henry Rosett award to Dr. Philip May in recognition of his substantial contributions to epidemiological studies on FASD.

show abstract

Section: Fast Data Presentationscontrasting

confidence: 99%

Proceedings of the 2014 Annual Meeting of the Fetal Alcohol Spectrum Disorders Study Group

Reynolds

Valenzuela

Medina

et al. 2015

Alcohol

View full text Add to dashboard Cite

show abstract

“…Neurodegeneration can be observed in these cell populations even following single ethanol exposure periods (Dikranian et al, 2005;(Goodlett and Eilers, 1997; Marcussen et al, 1994), such as those used in the present study. Moreover, developmental alcohol exposure can influence the structure and function of surviving cells, reducing myelin (Zoeller et al, 1994), reducing synaptic connections (Klintsova et al, 2002), altering receptor and ion channel function (Gruol and Parsons, 1996; Incerti et al, 2010; Servais et al, 2007), and impairing plasticity (Servais et al, 2007). It is possible that any of these alcohol effects could contribute to motor deficits and/or be affected by memantine administration.…”

Section: Discussionmentioning

confidence: 99%

Administration of Memantine During Ethanol Withdrawal in Neonatal Rats: Effects on Long-Term Ethanol-Induced Motor Incoordination and Cerebellar Purkinje Cell Loss

Idrus

McGough

Riley

et al. 2010

Alcoholism: Clinical and Experimental Research

View full text Add to dashboard Cite

Background Alcohol consumption during pregnancy can damage the developing fetus, illustrated by central nervous system dysfunction and deficits in motor and cognitive abilities. Binge drinking has been associated with an increased risk of fetal alcohol spectrum disorders, likely due to increased episodes of ethanol withdrawal. We hypothesized that overactivity of the N-methyl-D-aspartate (NMDA) receptor during ethanol withdrawal leads to excitotoxic cell death in the developing brain. Consistent with this, administration of NMDA receptor antagonists (e.g. MK-801) during withdrawal can attenuate ethanol's teratogenic effects. The aim of this study was to determine if administration of memantine, an NMDA receptor antagonist, during ethanol withdrawal could effectively attenuate ethanol-related deficits, without the adverse side effects associated with other NMDA receptor antagonists. Methods Sprague-Dawley pups were exposed to 6.0 g/kg ethanol or isocaloric maltose solution via intubation on postnatal day 6, a period of brain development equivalent to a portion of the 3rd trimester. Twenty-four and 36 hours after ethanol, subjects were injected with 0, 10 or 15 mg/kg memantine, totaling doses of 0, 20, or 30 mg/kg. Motor coordination was tested on a parallel bar task and the total number of cerebellar Purkinje cells was estimated using unbiased stereology. Results Alcohol exposure induced significant parallel bar motor incoordination and reduced Purkinje cell number. Memantine administration significantly attenuated both ethanol-associated motor deficits and cerebellar cell loss in a dose-dependent manner. Conclusions Memantine was neuroprotective when administered during ethanol withdrawal. These data provide further support that ethanol withdrawal contributes to fetal alcohol spectrum disorders.

show abstract

“…Several lines of animal research suggest the promise of various prenatal and neonatal interventions, including prenatal and postnatal treatment with neuroprotective Child Psychiatry Hum Dev peptides [127] and various nutrients [128][129][130][131][132]. Other research has demonstrated positive effects of neonatal handling, postnatal environment enrichment, and rehabilitative training on rats and mice with perinatal alcohol exposure [133].…”

Section: Treatmentmentioning

confidence: 96%

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Kable

O’Connor

Olson

et al. 2015

Child Psychiatry Hum Dev

105

101

View full text Add to dashboard Cite

Over the past 40 years, a significant body of animal and human research has documented the teratogenic effects of prenatal alcohol exposure (PAE). Neurobehavioral Disorder associated with PAE is proposed as a new clarifying term, intended to encompass the neurodevelopmental and mental health symptoms associated with PAE. Defining this disorder is a necessary step to adequately characterize these symptoms and allow clinical assessment not possible using existing physically-based diagnostic schemes. Without appropriate diagnostic guidelines, affected individuals are frequently misdiagnosed and treated inappropriately (often to their considerable detriment) by mental health, educational, and criminal justice systems. Three core areas of deficits identified from the available research, including neurocognitive, self-regulation, and adaptive functioning impairments, are discussed and information regarding associated features and disorders, prevalence, course, familial patterns, differential diagnosis, and treatment of the proposed disorder are also provided.

show abstract

Reversal of Alcohol-Induced Learning Deficits in the Young Adult in a Model of Fetal Alcohol Syndrome

Cited by 29 publications

References 25 publications

Proceedings of the 2014 Annual Meeting of the Fetal Alcohol Spectrum Disorders Study Group

Proceedings of the 2014 Annual Meeting of the Fetal Alcohol Spectrum Disorders Study Group

Administration of Memantine During Ethanol Withdrawal in Neonatal Rats: Effects on Long-Term Ethanol-Induced Motor Incoordination and Cerebellar Purkinje Cell Loss

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Contact Info

Product

Resources

About