Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice

Bhutada, Pravinkumar; Mundhada, Yogita; Bansod, Kuldeep; Ubgade, Alok; Quazi, Mohsin; Umathe, Sudhir N.; Mundhada, Dharmendra

doi:10.1016/j.pnpbp.2010.04.025

Cited by 107 publications

(68 citation statements)

References 62 publications

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“…On the other hand, Monsef-Esfahani and his colleagues (2010) have isolated quercetin from S. striata compounds. In line with this subject, several previous studies have indicated the neuroprotective, anxiolytic and antidepressant effects of this flavonoid in laboratory animals (Aguirre-Hernández et al, 2010;Bhutada et al, 2010;Cho et al, 2006). Nowadays, many researches have focused on the study of the effects of natural products for the treatment of psychiatric disorders in humans using animal models.…”

Section: Introductionmentioning

confidence: 85%

“…In line with these findings, a recently published study conducted by Monsef-Esfahani et al (2010) showed the presence of quercetin as an effective compound in this plant. On the other hand, some authors have reported that quercetin can decrease anxiety and depression (AguirreHernández et al, 2010;Bhutada et al, 2010) and there is also a relationship between quercetin function and neurotransmitter systems in the CNS (Goutman & Calvo, 2004;Kambe et al, 2010;Rotelli et al, 2009) which may alter psychiatric behaviors through indirect mechanisms. To explore this issue further, we have investigated interaction between the effects of S. striata and the GABAergic system in the brain.…”

Section: Discussionmentioning

confidence: 99%

“…In the next step, CRF stimulates secretion of adrenocorticotropin hormone from the anterior pituitary and the stress hormone such as cortisol in humans and corticosterone in rodents (Bhutada et al, 2010). As a consequence, it should be emphasized that the CRF system is responsible for the regulation of anxiety and depression behaviors.…”

Section: Discussionmentioning

confidence: 99%

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Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects ofScrophularia striataextract in rats

Kosari‐Nasab

Babri

Fatehi-Gharehlar

et al. 2013

Pharmaceutical Biology

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Context: Neuropsychiatric disorders, like anxiety and depression, are global problems for clinical researchers in neurology. Recently, some authors have shown neuroprotective and antiinflammatory effects of Scrophularia striata Boiss (Scrophulariaceae) extract in rodents. Objective: The purpose of the current study was to investigate the effects of S. striata extract on anxiety and depressant-like behaviors and find a possible mechanism for these impacts. Materials and methods: In this study, the elevated plus-maze (EPM) and forced swimming test (FST), which are useful models for selective identification of anxiolytic and antidepressant drug effects in rodents, were used. We investigated the effects of S. striata ethanol extract at different doses (20, 50, 100, 160 and 220 mg/kg) on anxiety and depression behaviors in the EPM and FST, and then we assessed the role of g-aminobutyric acid (GABA) A receptor in modulation of the effects of S. striata extract in the brain. Results: Our results showed that effective doses of S. striata (100 and 160 mg/kg) increased the percentages of open arm time and entries in the EPM and decreased immobility time in the FST in comparison with control group, indicating anxiolytic and antidepressant effects, respectively. Moreover, intracerebroventricular administration of GABA A receptor agonist (muscimol; 1 mg/ rat) enhanced the impact of S. striata, and GABA A receptor antagonist (bicuculline; 1 mg/rat) blocked these effects in rats, indicating that significant interactions existed between S. striata and the GABAergic system in the brain. Discussion and conclusion: Findings of this study suggest that anxiolytic and antidepressant effects of S. striata may be modulated via the GABAergic system.

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Section: Introductionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects ofScrophularia striataextract in rats

Kosari‐Nasab

Babri

Fatehi-Gharehlar

et al. 2013

Pharmaceutical Biology

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“…Over time the quercetin dose had the strongest suppression on cortisol levels. They then examined the rats' brains and observed that quercetin can inhibit the release of corticotropin-releasing hormone [20] . One of the reasons for decrease in cortisol level with quercetin treatment is elevation of oxytocin.…”

Section: Discussionmentioning

confidence: 99%

Bisfenol A Verilen Ratlarda Kuersetinin Kortizol ve Oksitosin Seviyeleri İle Oksitosin Reseptör Gen Ekspresyonu ve Uterus Morfometrisi Üzerine Etkileri

Jamei¹,

Sadeghi²

2016

Kafkas Univ Vet Fak Derg

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This study was carried out to evaluate effects of quercetin and bisphenol A (BPA), alone and in combination, on plasma cortisol and oxytocin levels, oxytocin receptor gene expression and morphometry of uterus in rat. After one week of acclimatization, twenty female rats were divided into four treatments as: control, received ethanol saline as injection intraperitoneally and gavaged hydroxypropylmethylcellulose (HPMC). The second group injected with 50 µg BPA per kg body weight dissolved in ethanol saline two times per week for 4 weeks. The third group gavaged 30 mg quercetin per kg body weight suspended in aqueous solution of HPMC two times per week for 4 weeks, while the fourth group was treated with quercetin along with BPA. Two days after final injection and gavage, rats were anesthetized and uterine and blood samples were collected. BPA alone increased plasma MDA level, decreased total antioxidant capacity (TCA) and had no effect (P>0.05) on oxytocin and cortisol levels in the plasma compared with control group. Quercetin along with BPA decreased MDA level, but had no effect (P>0.05) on TCA, oxytocin and cortisol levels compared to control. Quercetin and BPA, alone or in combination, resulted in increase (P<0.05) oxytocin receptor gene expression. Treatment with quercetin along with BPA increased (P<0.05) endometrium, but had no effect (P>0.05) on myometrium and epimetrium. It was indicated that quercetin may be a potential compound for reducing oxidative stress damages in uterus layer and increasing blood oxytocin level and its receptor in uterine, but cannot completely ameliorate the negative effects of BPA. Keywords ÖzetBu çalışma birlikte ve ayrı ayrı kuersetin ve bisfenol A (BPA) uygulamalarının ratlarda plazma kortizol ve oksitosin seviyelerine, oksitosin reseptör gen ekspresyonuna ve uterus morfometrisine etkilerini araştırmak amacıyla yapılmıştır. Bir haftalık alıştırma dönemi sonrasında 20 dişi rat dört gruba ayrıldı. Kontrol grubuna intraperitoneal etanol-salin enjeksiyonu ile birlikte hidroksipropilmetilselüloz (HPMC) gavaj yoluyla uygulandı. İkinci gruba 4 hafta boyunca haftada iki kere olmak üzere etanol-salinde çözdürülmüş BPA 50 µg/vücut ağırlığı dozunda enjekte edildi. Üçüncü gruba 4 hafta boyunca haftada iki kere olmak üzere HPMC içinde çözdürülmüş edilmiş kuersetin 30 mg/vücut ağırlığı dozunda gavaj yoluyla verilirken dördüncü gruba kuersetin ile birlikte BPA verildi. Son enjeksiyon ve gavaj uygulamasından 2 gün sonra ratlar anestezi uygulanarak uterus dokuları ve kan örnekleri toplandı. Tek başına BPA uygulaması plazma MDA seviyesini artırırken total antioksidan kapasiteyi düşürdü (TCA). BPA uygulaması plazma oksitosin ve kortizol seviyelerinde ise konrol grubu ile karşılaştırıldığında bir değişime neden olmadı (P>0.05). Kuersetin ve BPA'nın birlikte uygulanması kontrol grubuyla karşılaştırıldığında MDA seviyesini düşürürken TCA, oksitosin ve kortizol seviyelerinde ise bir değişime neden olmadı (P>0.05). Kuersetin ve BPA'nın tek başlarına veya birlikte uygulanması oksitosin resept...

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“…The flavonol glycosides have been said to be responsible for the free radical scavenging character of the extract. Quercetin (3,3',4',5,7-pentahydroxyflavone), one of the major constituents of the flavonol glycosides, has been independently shown to lower cortisol levels in rodent models of stress [24] [25] and is found in many foods items such as onions, apples, berries, tea, grapes, red wine and prickly pear. In fact, the prickly pear (Opuntia Streptacantha), which is used in Mexican folklore to treat T2DM, has been shown to have anti-hyperglycemic effects in rats [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of <i>Ginkgo biloba</i> Extract Ingestion on Plasma Total Cortisol Levels during an Oral Glucose Tolerance Test in Normal Glucose Tolerant Individuals

Kudolo¹

2014

FNS

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Protracted periods of increased cortisol production, as may be seen in an acute illness, may lead to transient hyperglycemia. Increasing evidence suggests that cortisol may then mediate the development of insulin resistance and potentially lead to the development of overt diabetes. Evidence in animal studies also suggests that under conditions of stress Ginkgo biloba extract could reduce plasma cortisol production and so the primary aim of this study was to determine the effect of Ginkgo biloba extract ingestion on plasma cortisol production during an acute period of glucose challenge. Healthy non-diabetic, glucose tolerant volunteers (n = 30, (10/20, M/F); age, 45.7 ± 9.9 years old) completed a randomized, double-blind, placebo-controlled crossover study when they ingested Ginkgo biloba extract (120 mg/day as a single dose) and placebo during each 3-month arm. A standard 75 g oral glucose tolerance test was performed at the end of each cycle and blood was collected and used to measure plasma glucose, insulin, c-peptide and cortisol. Fasting plasma cortisol was significantly lower after the Ginkgo biloba cycle than the placebo cycle (326 ± 149 vs. 268 ± 121 nmol/L, respectively; p = 019). The plasma cortisol area under the curve during the 2-hour test (AUC0-2) was also significantly lower after ingestion of the Ginkgo biloba cycle compared to the placebo (668 ± 265 vs. 530 ± 213 nmol/L/h, respectively; p < 0.001). It is concluded that the ingestion of Ginkgo biloba extract has effect on the hypothalamic-pituitary-adrenal axis leading to reduced basal cortisol levels and reduced cortisol production in response to acute hyperglycemic challenge.

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Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice

Cited by 107 publications

References 62 publications

Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects ofScrophularia striataextract in rats

Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects ofScrophularia striataextract in rats

Bisfenol A Verilen Ratlarda Kuersetinin Kortizol ve Oksitosin Seviyeleri İle Oksitosin Reseptör Gen Ekspresyonu ve Uterus Morfometrisi Üzerine Etkileri

Effect of <i>Ginkgo biloba</i> Extract Ingestion on Plasma Total Cortisol Levels during an Oral Glucose Tolerance Test in Normal Glucose Tolerant Individuals

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Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice

Cited by 107 publications

References 62 publications

Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects ofScrophularia striataextract in rats

Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects ofScrophularia striataextract in rats

Bisfenol A Verilen Ratlarda Kuersetinin Kortizol ve Oksitosin Seviyeleri İle Oksitosin Reseptör Gen Ekspresyonu ve Uterus Morfometrisi Üzerine Etkileri

Effect of &lt;i&gt;Ginkgo biloba&lt;/i&gt; Extract Ingestion on Plasma Total Cortisol Levels during an Oral Glucose Tolerance Test in Normal Glucose Tolerant Individuals

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Effect of <i>Ginkgo biloba</i> Extract Ingestion on Plasma Total Cortisol Levels during an Oral Glucose Tolerance Test in Normal Glucose Tolerant Individuals