Submillimeter rotational lines of H 2 O are a powerful probe in warm gas regions of the interstellar medium (ISM), tracing scales and structures ranging from kiloparsec disks to the most compact and dust-obscured regions of galactic nuclei. The ortho-H 2 O(4 23 -3 30 ) line at 448 GHz, which was recently detected in a local luminous infrared galaxy (Pereira-Santaella et al. 2017), offers a unique constraint on the excitation conditions and ISM properties in deeply buried galaxy nuclei since the line requires high far-infrared optical depths to be excited. In this letter, we report the first high-redshift detection of the 448 GHz H 2 O(4 23 -3 30 ) line using ALMA, in a strongly lensed submillimeter galaxy (SMG) at z = 3.63. After correcting for magnification, the luminosity of the 448 GHz H 2 O line is ∼ 10 6 L . In combination with three other previously detected H 2 O lines, we build a model that "resolves" the dusty ISM structure of the SMG, and find that it is composed of a ∼ 1 kpc optically thin (optical depth at 100 µm τ 100 ∼ 0.3) disk component with dust temperature T dust ≈ 50 K emitting a total infrared power of 5 × 10 12 L with surface density Σ IR = 4 × 10 11 L kpc −2 , and a very compact (0.1 kpc) heavily dust-obscured (τ 100 1) nuclear core with very warm dust (100 K) and Σ IR = 8 × 10 12 L kpc −2 . The H 2 O abundance in the core component, X H 2 O ∼ (0.3-5) × 10 −5 , is at least one order of magnitude higher than in the disk component. The optically thick core has the characteristic properties of an Eddington-limited starburst, providing evidence that radiation pressure on dust is capable of supporting the ISM in buried nuclei at high redshifts. The multi-component ISM structure revealed by our models illustrates that dust and molecules such as H 2 O are present in regions characterized by highly differing conditions and scales, extending from the nucleus to more extended regions of SMGs.