Revealing the Nature of Interaction between Graphene Oxide and Lipid Membrane by Surface-Enhanced Infrared Absorption Spectroscopy

Wu, Lie; Zeng, Li; Jiang, Xiue

doi:10.1021/jacs.5b03803

Cited by 85 publications

(90 citation statements)

References 40 publications

(29 reference statements)

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“…Based on these observations, we summarized our findings in Figure 1C, D. Previous studies indicated that water mediates the hydrogen bonding interaction between DOPC liposomes and GO, 20 and thus the interface between these two is not fully dehydrated. In addition, DOPC and GO interact mainly on the edge of GO, which is more hydrophilic than the carbon-rich domains in the interior.…”

Section: Resultssupporting

confidence: 61%

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Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry

2016

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ABSTRACT:The interaction between graphene oxide (GO) and lipid bilayers is important for fundamental surface science and many applications. In this work, isothermal titration calorimetry (ITC), cryo-TEM, and fluorescence spectroscopy were used to study the adsorption of three types of liposomes. Heat release was observed when GO was mixed with zwitterionic DOPC liposomes, while heat absorption occurred with cationic DOTAP liposomes. For comparison, anionic DOPG liposomes released heat when mixed with DOTAP. DOPC was adsorbed as intact liposomes but DOTAP ruptured and induced stacking and folding of GO sheets. This study suggests the release of more water molecules from the GO surface when mixed with DOTAP liposomes. This can be rationalized by the full rupture of the DOTAP liposomes interacting with the whole GO surface, including hydrophobic regions; while DOPC liposomes only interact with a small area on GO near the edge, which is likely to be more hydrophilic. This interesting biointerfacial observation has enhanced our fundamental understanding of lipid/GO interactions.

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Section: Resultssupporting

confidence: 61%

“…In the case of DOPC adsorption, water release is not a main factor, and their hydrogen bonding interaction is believed to be mediated by a water molecule. 20 It is the removal of extra salt ions that consumed the enthalpy.…”

Section: Resultsmentioning

confidence: 99%

Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry

2016

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“…At least four kinds of interactive forces exist: electrostatic attraction, electrostatic repulsion, hydrogen bonding, and hydrophobic interaction (Wu et al 2015). It is well known that a GO membrane can be strengthened by crosslinking with divalent metal ions (Park et al 2008).…”

Section: Stability Of Go Membranes In DI Watermentioning

confidence: 99%

Development of a stable cation modified graphene oxide membrane for water treatment

Graham

2017

2D Mater.

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Membranes prepared from layers of graphene oxide (GO) offer substantial advantages over conventional materials for water treatment (e.g. greater flux), but the stability of GO membranes in water has not been achieved until now. In this study the behavior of GO membranes prepared with different quantities and species of cations has been investigated to establish the feasibility of their application in water treatment. A range of cation-modified GO membranes were prepared and exposed to aqueous solutions containing specific chemical constituents. In pure water, unmodified and Na-modified GO membranes were highly unstable, while GO membranes modified with multivalent cations were stable provided there were sufficient quantities of cations present; their relative capability to achieve GO stability was as follows: Al 3+ > Ca 2+ > Mg 2+ > Na + . It is believed that the mechanism of cross-linking, and membrane stability, is via metal-carboxylate chelates and cation-graphite surface interactions (cation-π interaction), and that the latter appears to increase with increasing cation valency. The instability of cation (Ca or Al)-modified GO membranes by NaCl solutions during permeation occurred as Na + exchanged with the incorporated multivalent cations, but a high content of Al 3+ in the GO membrane impeded Al 3+ /Na + exchange and thus retained membrane stability. In solutions containing biopolymers representative of surface waters or seawater (protein and polysaccharide solutions), Ca-GO membranes (even with high Ca 2+ content) were not stable, while Al-GO membranes were stable if the Al 3+ content was sufficiently high; Al-formed membranes also had a greater flux than Ca-GO membranes. PAPEROriginal content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence.

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“…For example, several groups have demonstrated that graphene oxide (GO) and reduced GO (rGO) nanosheets exerted hemolysis effects on red blood cells (RBCs) . This hemolytic toxicity is suggested to be related to the destructive effect of Gr nanosheets on cell membranes . These studies indicated the underlying molecular mechanism for this cell membrane destruction is due to the strong dispersion interactions between Gr and lipid molecules—Gr and its derivatives cannot only insert/penetrate into the cell membrane, but also extract large amounts of phospholipids molecules directly from the cell membrane, thus eventually cause membrane stress and degradation.…”

Section: Introductionmentioning

confidence: 99%

Superior Compatibility of C₂N with Human Red Blood Cell Membranes and the Underlying Mechanism

Liu

Zhang

Zhao

et al. 2018

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The widespread use of nanomaterials, such as carbon based 2D nanomaterials, in biomedical applications, has been accompanied by a growing concern on their biocompatibility, and in particular, on how they may affect the integrity of cell membranes. Herein, the interactions between C 2 N, a novel 2D nanomaterial, and human red blood cell membranes are explored using a combined experimental and theoretical approach. The experimental microscopies show that C 2 N exerts a negligible hemolysis effect on the blood cells with a superior compatibility to their cell membranes, when compared with the control system, reduced graphene oxide (rGO), which is found to be highly hemolytic. The molecular dynamics simulations further reveal the underlying molecular mechanisms, which indicate that C 2 N prefers to be adsorbed flat on the water-membrane interface. Interaction energy analyses demonstrate the crucial role of Coulombic contributions, originating from the unique electrostatic potential surface of C 2 N, in preventing C 2 N from penetrating into cell membranes. These findings indicate a high compatibility of C 2 N with cell membranes, which may provide useful foundation for the future exploration of this 2D nanomaterial in related biomedical applications.

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Revealing the Nature of Interaction between Graphene Oxide and Lipid Membrane by Surface-Enhanced Infrared Absorption Spectroscopy

Cited by 85 publications

References 40 publications

Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry

Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry

Development of a stable cation modified graphene oxide membrane for water treatment

Superior Compatibility of C₂N with Human Red Blood Cell Membranes and the Underlying Mechanism

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Revealing the Nature of Interaction between Graphene Oxide and Lipid Membrane by Surface-Enhanced Infrared Absorption Spectroscopy

Cited by 85 publications

References 40 publications

Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry

Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry

Development of a stable cation modified graphene oxide membrane for water treatment

Superior Compatibility of C2N with Human Red Blood Cell Membranes and the Underlying Mechanism

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Product

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Superior Compatibility of C₂N with Human Red Blood Cell Membranes and the Underlying Mechanism