Revealing the antiaging effects of cereal- and food oil-derived active substances by a <i>Caenorhabditis elegans</i> model

Xu, Dakang; Lin, Qinlu; Wu, Wei; Wu, Yixin; Liang, Ying

doi:10.1039/d0fo02240c

Cited by 6 publications

(4 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The administered dose of 50 μL promoted the reproductive capacity of C. elegans , while the other trials had the opposite results. It is reported that the reproductive capacity was related to the DAF-16/FoxO, which could be decreased by ACNs [ 15 ]. Compared with control, the spawning numbers in the 75, 100, 150, and 300 μL trials decreased by 24.9%, 28.7%, 46.6%, and 74.5%, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Currently, Caenorhabditis elegans is a well-established model in genetics, which has been fully sequenced and is widely utilized in aging-related studies due to its short life cycle, rapid reproduction rate, and clear life extension mechanism [ 2 , 5 , 6 ]. It has been reported that some natural products have been shown to increase the lifespan of C. elegans , such as flavonoids [ 7 , 8 , 9 , 10 ], saponins [ 11 , 12 ], polysaccharides [ 13 , 14 ], cereal, and food-derived oil [ 15 ]. Anthocyanins (ACNs), a class of plant secondary metabolites, are natural pigments in plants which are stable in acid conditions [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of Dendrobium officinale Flower Anthocyanin and Extended Lifespan in Caenorhabditis elegans

Wang

Zhang

et al. 2022

Molecules

View full text Add to dashboard Cite

The Dendrobium officinale flower is a non-medicinal part of the plant, rich in a variety of nutrients and bioactive ingredients. The purpose of this article was to explore the preparation conditions of anthocyanins (ACNs) from the D. officinale flower. Subsequently, its anti-aging effects were evaluated with Caenorhabditis elegans. Results showed that the ACNs had antioxidant activities on scavenging free radicals (DPPH· and ABTS+·), and the clearance rate was positively correlated with the dose. Additionally, ACNs significantly increased the activity of superoxide dismutase (SOD) in C. elegans, which was 2.068-fold higher than that of the control. Treatment with ACNs at 150 μL extended the lifespan of C. elegans by 56.25%, and treatment with ACNs at 50 μL promoted fecundity in C. elegans. Finally, the protective effect of ACNs enhanced stress resistance, thereby increasing the survival numbers of C. elegans, which provided insights for the development and practical application of functional products.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of Dendrobium officinale Flower Anthocyanin and Extended Lifespan in Caenorhabditis elegans

Wang

Zhang

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…AAs are important functional nutrients in cereal grains and are indispensable molecules in many biochemical synthesis pathways [31]. AAs are fundamental constituents of proteins and are precursors of other secondary metabolites [32].…”

Section: Introductionmentioning

confidence: 99%

Integrated Metabolome and Transcriptome Analyses Reveal Amino Acid Biosynthesis Mechanisms during the Physiological Maturity of Grains in Yunnan Hulled Wheat (Triticum aestivum ssp. yunnanense King)

Zhang,

Zhang

et al. 2023

IJMS

View full text Add to dashboard Cite

Yunnan hulled wheat (YHW) possesses excellent nutritional characteristics; however, the precise amino acid (AA) composition, contents, and molecular mechanisms underlying AA biosynthesis in YHW grains remain unclear. In this study, we aimed to perform metabolomic and transcriptomic profiling to identify the composition and genetic factors regulating AA biosynthesis during the physiological maturation of grains of two YHW genotypes, Yunmai and Dikemail, with high and low grain protein contents, respectively. A total of 40 and 14 differentially accumulated amino acids (AAs) or AA derivatives were identified between the waxy grain (WG) and mature grain (MG) phenological stages of Yunmai and Dikemail, respectively. The AA composition differed between WG and MG, and the abundance of AAs—especially that of essential AAs—was significantly higher in WG than in MG (only 38.74–58.26% of WG). Transcriptome analysis revealed differential regulation of structural genes associated with the relatively higher accumulation of AAs in WG. Weighted gene co-expression network analysis and correlation analyses of WG and MG indicated differences in the expression of clusters of genes encoding both upstream elements of AA biosynthesis and enzymes that are directly involved in AA synthesis. The expression of these genes directly impacted the synthesis of various AAs. Together, these results contribute to our understanding of the mechanism of AA biosynthesis during the different developmental stages of grains and provide a foundation for further research to improve the nutritional value of wheat products.

show abstract

“…Although in vitro models are useful as preliminary studies to evaluate bioactive potential, in vivo studies are required to further prove the bioactive effects of food derived compounds. Unfortunately, many of the typically used in vivo models are costly, time consuming, and can have complicated genetics ( Upadhyay and Palmberg, 2018 ; Xu et al, 2021 ). For this reason, researchers are looking at alternative in vivo models, such as Caenorhabditis elegans , to be a more practical model for studying the effects of food derived bioactive compounds in vivo .…”

Section: Introductionmentioning

confidence: 99%

Caenorhabditis elegans as an in vivo model for food bioactives: A review

Mudd

Liceaga

2022

Current Research in Food Science

View full text Add to dashboard Cite

Revealing the antiaging effects of cereal- and food oil-derived active substances by a Caenorhabditis elegans model

Abstract: Cereal grains and oils contain various functional ingredients, such as amino acids, peptides, polyphenols, dietary fiber, linoleic acid, and natural pigments. Their biological activities are of great significance. Benefiting from...

Cited by 6 publications

References 90 publications

Preparation of Dendrobium officinale Flower Anthocyanin and Extended Lifespan in Caenorhabditis elegans

Preparation of Dendrobium officinale Flower Anthocyanin and Extended Lifespan in Caenorhabditis elegans

Integrated Metabolome and Transcriptome Analyses Reveal Amino Acid Biosynthesis Mechanisms during the Physiological Maturity of Grains in Yunnan Hulled Wheat (Triticum aestivum ssp. yunnanense King)

Caenorhabditis elegans as an in vivo model for food bioactives: A review

Contact Info

Product

Resources

About