Revealing the amyloid β-protein with zinc finger protein of micronucleus during Alzheimer's disease progress by a quaternary ammonium terpyridine probe

Ding, Haitao; Liu, S; Chen, Junyang; Tian, Yupeng; Pan, Dayi; Chen, Lei; Rizzello, Loris; Zheng, Xiaowei; Battaglia, Giuseppe; Luo, Kui; Gong, Qiyong; Tian, Xiaohe

doi:10.1016/j.bios.2023.115446

Cited by 1 publication

(1 citation statement)

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“…A recently developed tool, called MATLAB‐based program for quantifying MN, would provide opportunity to quantitatively and accurately analyze MN in brain tissues of AD mice models (Yano et al., 2021 ). Interestingly, a recent study developed a fluorescence probe that is able to specifically target MN (Ding et al., 2023 ). They demonstrated that there is an age‐related increase of MN in cerebral cortex (but not hippocampus) of APP/PS1 mice, and the increase of MN is positively correlated with the Aβ deposition in cerebral cortex.…”

Section: Discussionmentioning

confidence: 99%

Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner

Guo,

Li,

et al. 2024

Aging Cell

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Although studies have demonstrated that genome instability is accumulated in patients with Alzheimer's disease (AD), the specific types of genome instability linked to AD pathogenesis remain poorly understood. Here, we report the first characterization of the age‐ and sex‐related trajectories of telomere length (TL) and micronuclei in APP/PS1 mice model and wild‐type (WT) controls (C57BL/6). TL was measured in brain (prefrontal cortex, cerebellum, pituitary gland, and hippocampus), colon and skin, and MN was measured in bone marrow in 6‐ to 14‐month‐old mice. Variation in TL was attributable to tissue type, age, genotype and, to a lesser extent, sex. Compared to WT, APP/PS1 had a significantly shorter baseline TL across all examined tissues. TL was inversely associated with age in both genotypes and TL shortening was accelerated in brain of APP/PS1. Age‐related increase of micronuclei was observed in both genotypes but was accelerated in APP/PS1. We integrated TL and micronuclei data with data on cognition performance and brain amyloidosis. TL and micronuclei were linearly correlated with cognition performance or Aβ40 and Aβ42 levels in both genotypes but to a greater extent in APP/PS1. These associations in APP/PS1 mice were dominantly driven by females. Together, our findings provide foundational knowledge to infer the TL and micronuclei trajectories in APP/PS1 mice during disease progression, and strongly support that TL attrition and micronucleation are tightly associated with AD pathogenesis in a female‐biased manner.

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Section: Discussionmentioning

confidence: 99%