Revealing Localised Mechanochemistry of Biomaterials Using In Situ Multiscale Chemical Analysis

Farr, Nicholas T. H.

doi:10.3390/ma15103462

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Figure 6E also highlights an additional SE peak range of interest being that of CH vibrations (CHx). CHx has previously been identified to show characteristic SE spectra within the range of 2.9–4.3 eV 35,36,41 . The CHx emission is most abundant in LT mesh compared to that of ST mesh.…”

Section: Resultsmentioning

confidence: 99%

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Characterization in respect to degradation of titanium‐coated polypropylene surgical mesh explanted from humans

2023

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Titanium-coated polypropylene (Ti-PP) mesh was introduced in 2002 as a surgical mesh for the treatment of hernias and shortly after for pelvic floor surgery, with the aim of improving biocompatibility when compared to non-titanised/regular PP mesh implants. The application of a titanium coating could also be beneficial to address concerns regarding the exposure of PP in an in vivo environment. Many studies have shown that PP, although it is widely accepted as a stable polymer, is subject to oxidation and degradation, such degradation affects the mechanical behavior, that is, the stiffness and tensile strength of PP mesh. Despite the wide clinical use of Ti-PP surgical meshes, no study has yet investigated the residual material properties post clinical deployment and subsequent explantation. In this study, two explanted Ti-PP mesh samples each having different incorporation durations from two patients were examined. Material analysis conducted within this study includes the following techniques: attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), Raman spectroscopy, low voltagescanning electron microscopy (LV-SEM), backscattered electron (BSE) imaging, energy dispersive X-ray spectroscopy (EDS) and secondary election hyperspectral imaging (SEHI). The hypothesis of this study is that the Ti coating successfully shields the PP mesh from oxidative stress in vivo and thus protects it from degradation. The results of this analysis show for the first time evidence of bulk oxidation, surface degradation, and environmental stress cracking on explanted Ti-PP meshes.

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Section: Resultsmentioning

confidence: 99%

“…CHx has previously been identified to show characteristic SE spectra within the range of 2.9–4.3 eV. 35 , 36 , 41 The CHx emission is most abundant in LT mesh compared to that of ST mesh. One of the limitations of SES is that SE peaks can often show overlapping chemical related emissions.…”

Section: Resultsmentioning

confidence: 99%

Characterization in respect to degradation of titanium‐coated polypropylene surgical mesh explanted from humans

2023

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“…Additionally, such in situ analysis should be carried out at low beam energies and beam currents to reduce the prospect of sample modification and charging. All these requirements are satisfied via the use of Secondary Electron Hyperspectral Imaging (SEHI) and the accompanying application of Secondary Electron Spectroscopy (SES) [ 12 , 13 , 14 ]. SEHI is made possible through use of through-the-lens detectors (TLDs) already installed on many available FIB-SEMs.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Quality of Oxygen Plasma Focused Ion Beam (O-PFIB) Etching on Polypropylene Surfaces Using Secondary Electron Hyperspectral Imaging

Farr,

Pasniewski,

de Marco

2023

Polymers

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The development of Focused Ion Beam–Scanning Electron Microscopy (FIB-SEM) systems has provided significant advances in the processing and characterization of polymers. A fundamental understanding of ion–sample interactions is still missing despite FIB-SEM being routinely applied in microstructural analyses of polymers. This study applies Secondary Electron Hyperspectral Imaging to reveal oxygen and xenon plasma FIB interactions on the surface of a polymer (in this instance, polypropylene). Secondary Electron Hyperspectral Imaging (SEHI) is a technique housed within the SEM chamber that exhibits multiscale surface sensitivity with a high spatial resolution and the ability to identify carbon bonding present using low beam energies without requiring an Ultra High Vacuum (UHV). SEHI is made possible through the use of through-the-lens detectors (TLDs) to provide a low-pass SE collection of low primary electron beam energies and currents. SE images acquired over the same region of interest from different energy ranges are plotted to produce an SE spectrum. The data provided in this study provide evidence of SEHI’s ability to be a valuable tool in the characterization of polymer surfaces post-PFIB etching, allowing for insights into both tailoring polymer processing FIB parameters and SEHI’s ability to be used to monitor serial FIB polymer surfaces in situ.

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Uncovering the relationship between macrophages and polypropylene surgical mesh

Farr,

Workman,

Saad

et al. 2024

Biomaterials Advances

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Revealing Localised Mechanochemistry of Biomaterials Using In Situ Multiscale Chemical Analysis

Cited by 3 publications

References 38 publications

Characterization in respect to degradation of titanium‐coated polypropylene surgical mesh explanted from humans

Characterization in respect to degradation of titanium‐coated polypropylene surgical mesh explanted from humans

Assessing the Quality of Oxygen Plasma Focused Ion Beam (O-PFIB) Etching on Polypropylene Surfaces Using Secondary Electron Hyperspectral Imaging

Uncovering the relationship between macrophages and polypropylene surgical mesh

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