Revealing anti-diabetic potency of medicinal plants of Meru Betiri National Park, Jember – Indonesia

Ratnadewi, Anak Agung Istri; Wahyudi, Lilik Duwi; Rochman, Jainur; Susilowati,; Nugraha, Ari Satia; Siswoyo, Tri Agus

doi:10.1016/j.arabjc.2018.01.017

Cited by 13 publications

(16 citation statements)

References 9 publications

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“…Indonesia has so many biodiversity consisting of more than 40.000 endemic plants, and 7000 among them reported as medical plants 6 . More than 400 plants have reported as hypoglycemic agent with various mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…Plants in the merremia genus are reported to contain phenolic compounds, flavonoids, sulfates, aliphatic pyrrolidine amides, tropane, and alkaloid 11 . In vitro study showed that leaves ethanol extract of Merremia hederacea and hexane fraction of Merremia mammosa had inhibitor activity of enzyme alpha amylase and alpha glucosidase 6,11 . In vivo study using streptozotocin induced diabetic rats showed extract etanol of Merremia tridentata, Merremia mammosa, Merremia emarginata, and Merremia hederacea have potential antidiabetic activity 11,12,13,&14 .…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Alpha Glucosidase Inhibitor Screening of Merremia peltata L. as Potential Traditional Treatment for Diabetes Mellitus

Af-idah

Hanafi

Elya³

2021

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Merremia peltata (L.) Merr.) is perennial herbaceous vine from Convolvulaceae family, which often wrapped around the other plants. M. peltata known as "Aka Lambuang" is an ethnobotanical plant used ABSTRACT Introduction: Merremia peltata is ethnomedicine plant used as traditional medicine in Sulawesi, Sumatra, Maluku and Papua. M. peltata is used for diabetic. Diabetes mellitus therapy with inhibit activity of alpha glucosidase enzyme could delay absorption of monosaccharides after a meal and interrupt glucose transport into the circulation. Objective: This research purpose is to investigate in vitro antioxidant activity and alpha glucosidase enzyme inhibitor leaves and stem extract of M. peltata. Method: The Stem and leaves of M. peltata were extracted sequentially using the UAE method using hexane, ethyl acetate, and methanol as mobile phase/solvent. The M. peltata extracts were subjected to the antioxidant activity assay by the DPPH radical scavenging and FRAP method. Antidiabetic activity was determined by an enzymatic alpha glucosidase inhibitor. Result: The extract which had best performance in antioxidant activity was stem ME with value of IC50 in DPPH 47.41 μg/mL and total antioxidant power 340.04 μmol/g. This study showed that leaves and stem extract of M .peltata have potential alpha glucosidase inhibitors for diabetic therapy. Stem ME had the best activity with IC50 value 47.44 μg/mL, almost two times better than acarbose as a positive control (IC50 = 98.38 μg/mL). Leaves ME, leaves EA, and stem EA also give better activity of alpha glucosidase inhibitors than acarbose with IC50 value 67.24 μg/mL, 69.38 μg/mL, and 72.85 μg/mL, respectively. Conclusion: M. peltata has potential antioxidant and alpha glucosidase inhibitor activity for diabetic therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant and Alpha Glucosidase Inhibitor Screening of Merremia peltata L. as Potential Traditional Treatment for Diabetes Mellitus

Af-idah

Hanafi

Elya³

2021

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“…Antidesma montanum Blume (Pani heloch) is a member of the family Euphorbiaceae, under the subfamily Phyllanthaceae, and the leaves of A. montanum have been considered as a wild vegetable [19,20], while traditional physicians have adopted different parts of the plant to treat ulcers, eye disease, lumber pain, hematochezia [21]. It is the most familiar and widespread of all species, and the plant is colloquially referred to as "Pani heloch."…”

Section: Introductionmentioning

confidence: 99%

“…It is the most familiar and widespread of all species, and the plant is colloquially referred to as "Pani heloch." The roots have been used internally to cure malaria, chickenpox, and measles and the leaf has been externally applied for thrush in children and headache in Malaysia [19]. The plant has also been used by native people in Indonesia for the healing of diabetes and is used as a medicinal plant in the Limu Mountains of China for the management of eye diseases [22].…”

Section: Introductionmentioning

confidence: 99%

“…The root was also used to prepare tea and the leaves have been reported as a means to relieve chest pain, dermatitis, and other skin diseases [23]. In previous research, the methanol extract presented some major isolated compounds of this plant-notably, 3,7,11,15-tetramethyl-2-hexadecen-1-ol, 9-ecosyne, hexadecanoic acid, gamma sitosterol, tridecanoic acid, 9-octadecenoic acid, 9,12-octadecadienoic acid, canophyllal, canophyllol, friedelin, antidesmanol, carpusin, and lupeolactone-and these compounds were also subjected to in silico molecular-docking experiments [19,24,25].…”

Section: Introductionmentioning

confidence: 99%

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Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms

et al. 2020

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Pani heloch (Antidesma montanum) is traditionally used to treat innumerable diseases and is a source of wild vegetables for the management of different pathological conditions. The present study explored the qualitative phytochemicals; quantitative phenol and flavonoid contents; in vitro antioxidant, anti-inflammatory, and thrombolytic effects; and in vivo antipyretic and analgesic properties of the methanol extract of A. montanum leaves in different experimental models. The extract exhibited secondary metabolites including alkaloids, flavonoids, flavanols, phytosterols, cholesterols, phenols, terpenoids, glycosides, fixed oils, emodines, coumarins, resins, and tannins. Besides, Pani heloch showed strong antioxidant activity (IC50 = 99.00 µg/mL), while a moderate percentage of clot lysis (31.56%) in human blood and significant anti-inflammatory activity (p < 0.001) was achieved with the standard. Moreover, the analgesic and antipyretic properties appeared to trigger a significant response (p < 0.001) relative to in the control group. Besides, an in silico study of carpusin revealed favorable protein-binding affinities. Furthermore, the absorption, distribution, metabolism, excretion, and toxicity analysis and toxicological properties of all isolated compounds adopted Lipinski’s rule of five for drug-like potential and level of toxicity. Our research unveiled that the methanol extract of A. montanum leaves exhibited secondary metabolites that are a good source for managing inflammation, pyrexia, pain, and cellular toxicity. Computational approaches and further studies are required to identify the possible mechanism which responsible for the biological effects.

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Antidesma montanum: Biochemistry and Bioactive Compounds

Ismail

Azmi

Mastuki

et al. 2019

Wild Fruits: Composition, Nutritional Value and Products

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Antidesma montanum is commonly known as a mountain currant tree. Its fruits and leaves are utilized locally for food and traditional medicine, meanwhile the stem is used as source of wood. The fruit contains bioactive constituents of steroid glycosides, saponins, flavonoids, polyphenols and tannins that exhibited higher antioxidant activity than at certain concentrations of standard antioxidants (i.e. vitamin E, ascorbic acid, and trolox). The leave extracts known to inhibit the activities of α-amylase and α-glucosidase in diabetic therapy. Furthermore, the leave extracts also possessed scavenging activity against both hydroxyl and superoxide anion radicals, and inhibited the nitric oxide production. Meanwhile, another studies reported on the anti-inflammatory effect of Antidesma montanum, being used to treat eye diseases, and relieving chest pain. The leaves are used externally against headache and thrush in children, for diuretic and removing kidney stone, anti-dermatitis and skin disease curing effect. A tea from the leaves is used as a tonic for mothers after giving birth and applied topically to ulcers and lumbar pains. The roots are used to treat measles, chickenpox, malaria, and stomach ache. Nevertheless, extensive research is needed to confirm the reputed beneficial effects of Antidesma montanum in traditional medicine.

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Revealing anti-diabetic potency of medicinal plants of Meru Betiri National Park, Jember – Indonesia

Cited by 13 publications

References 9 publications

Antioxidant and Alpha Glucosidase Inhibitor Screening of Merremia peltata L. as Potential Traditional Treatment for Diabetes Mellitus

Antioxidant and Alpha Glucosidase Inhibitor Screening of Merremia peltata L. as Potential Traditional Treatment for Diabetes Mellitus

Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms

Antidesma montanum: Biochemistry and Bioactive Compounds

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