RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma
Haidy A. Saleh,
Nicola Mitwasi,
Liliana R. Loureiro
et al.
Abstract:In recent studies, we have established the unique adapter chimeric antigen receptor (CAR) platform RevCAR which uses, as an extracellular CAR domain, a peptide epitope instead of an antibody domain. RevCAR adapters (termed RevCAR target modules, RevTMs) are bispecific antibodies that enable the reversible ON/OFF switch of the RevCAR system, improving the safety compared to conventional CARs. Here, we describe for the first time its use for retargeting of both T and NK-92 cells. In addition, we describe the dev… Show more
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