Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis

Park, In-Su; Mahapatra, Chinmaya; Park, Ji Sun; Dashnyam, Khandmaa; Kim, Jongwan; Ahn, Jin Ho; Chung, Phil‐Sang; Yoon, Dong Suk; Mandakhbayar, Nandin; Singh, Rajendra K.; Lee, Jung Hwan; Leong, Kam W.; Kim, Hae‐Won

doi:10.1016/j.biomaterials.2020.119919

Cited by 57 publications

(31 citation statements)

References 96 publications

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“…It is worth mentioning that surface functionalization of nanofibrous scaffolds by angiogenic bioactive molecules was also proven as a feasible approach for promoting tissue repair and regeneration [42,43]. Apart from these molecules, enhanced neovascularization could be achieved by adding inorganic elements (e.g., cerium and europium) to electrospun scaffolds [44][45][46]. Although there are several inorganic elements with the potential ability to induce angiogenesis, the risk of cytotoxicity and genotoxicity still limits their extensive use in tissue engineering applications [47].…”

Section: Fiber Orientationmentioning

confidence: 99%

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

et al. 2020

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Angiogenesis (or the development of new blood vessels) is a key event in tissue engineering and regenerative medicine; thus, a number of biomaterials have been developed and combined with stem cells and/or bioactive molecules to produce three-dimensional (3D) pro-angiogenic constructs. Among the various biomaterials, electrospun nanofibrous scaffolds offer great opportunities for pro-angiogenic approaches in tissue repair and regeneration. Nanofibers made of natural and synthetic polymers are often used to incorporate bioactive components (e.g., bioactive glasses (BGs)) and load biomolecules (e.g., vascular endothelial growth factor (VEGF)) that exert pro-angiogenic activity. Furthermore, seeding of specific types of stem cells (e.g., endothelial progenitor cells) onto nanofibrous scaffolds is considered as a valuable alternative for inducing angiogenesis. The effectiveness of these strategies has been extensively examined both in vitro and in vivo and the outcomes have shown promise in the reconstruction of hard and soft tissues (mainly bone and skin, respectively). However, the translational of electrospun scaffolds with pro-angiogenic molecules or cells is only at its beginning, requiring more research to prove their usefulness in the repair and regeneration of other highly-vascularized vital tissues and organs. This review will cover the latest progress in designing and developing pro-angiogenic electrospun nanofibers and evaluate their usefulness in a tissue engineering and regenerative medicine setting.

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Section: Fiber Orientationmentioning

confidence: 99%

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

et al. 2020

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“…Indeed, CeONP in response to great levels of oxidative stress preserved endothelial survivability through intracellular ROS scavenging that in the long run supported the formation of tubular networks and other endothelial cell functions. Therefore, the Ref-1/APE1 signaling pathway connected to the activation of HIF-1α can directly support the angiogenic effects of CeONPs [134].…”

Section: Angiogenesis Activitymentioning

confidence: 98%

“…More recently, Park et al have provided a deeper understanding of CeONP-induced revascularization irrespective of oxygen concentrations [134]. In this regard, they investigated the effectiveness of CeONPs in regenerating tissues during normoxia and a specific type of ROS-associated damage called critical limb ischemia.…”

Section: Angiogenesis Activitymentioning

confidence: 99%

Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering

Hosseini

Mozafari

2020

Materials

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Submicron biomaterials have recently been found with a wide range of applications for biomedical purposes, mostly due to a considerable decrement in size and an increment in surface area. There have been several attempts to use innovative nanoscale biomaterials for tissue repair and tissue regeneration. One of the most significant metal oxide nanoparticles (NPs), with numerous potential uses in future medicine, is engineered cerium oxide (CeO2) nanoparticles (CeONPs), also known as nanoceria. Although many advancements have been reported so far, nanotoxicological studies suggest that the nanomaterial’s characteristics lie behind its potential toxicity. Particularly, physicochemical properties can explain the positive and negative interactions between CeONPs and biosystems at molecular levels. This review represents recent advances of CeONPs in biomedical engineering, with a special focus on tissue engineering and regenerative medicine. In addition, a summary report of the toxicity evidence on CeONPs with a view toward their biomedical applications and physicochemical properties is presented. Considering the critical role of nanoengineering in the manipulation and optimization of CeONPs, it is expected that this class of nanoengineered biomaterials plays a promising role in the future of tissue engineering and regenerative medicine.

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“…From the tissue engineering point of view, CNPs offer prominent biological features for accelerating tissue repair and regeneration, including antioxidant, anti-inflammatory, antibacterial, angiogenic, and antiapoptotic activities [ 16 , 17 , 18 , 19 , 20 ]. There are huge numbers of experimental studies clarifying the therapeutic effectiveness of CNPs, either in bare or functionalized forms for biomedical applications [ 19 ]. For example, samarium ion-doped CeO 2 (SmCeO 2 ) nanoparticles conjugated with (6-(2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-hexyl) triethoxysilane moieties can improve endothelial cells (ECs) proliferation, overexpress proangiogenic markers (p38 MAPK/HIF-1α), and induce neovascularization in a chick embryo [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis

Cited by 57 publications

References 96 publications

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

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