Revamping squid gladii to biodegradable composites: In situ grafting of polyaniline to β-chitin and their antibacterial activity

Abstract

The global health concern on wound care is becoming more challenging with the emerging prevalence of inexorable antibiotic resistance. Amidst this crisis, various material innovations have been made to combat this dilemma. Herein, squid pens, which are regarded as discards in the seafood industry, were biorefined into β-chitin-graft-polyaniline (β-chitin-g-PANI) composites for possible wound dressing development. β-chitin was first chemically extracted from gladii, and was then grafted with PANI via in situ chemical oxidative polymerization of various concentrations of aniline, to produce the β-chitin-g-PANI composites. Supporting data from FTIR, UV-Vis, SEM, TGA, and DSC suggest that β-chitin was successfully grafted with PANI. Moreover, improved conductivity and in vitro degradation of the composites were observed as compared to β-chitin and PANI alone, respectively. Zones of inhibition observed from agar diffusion method suggest that the synthesized composites have antibacterial activity against E. coli and S. aureus. The resulting physicochemical and biological properties of integrating conducting PANI to β-chitin substantiated and rendered the β-chitin-g-PANI composites desirable candidates for the development wound care products.

Brush-like Polyaniline with Optical and Electroactive Properties at Neutral pH and High Temperature

“…The BL PAni presents only one endothermic peak at 114 °C. The conventional systems with PAni grafts have copolymer main chain transitions and an exothermic peak at 250 °C corresponding to polymer degradation [ 64 , 65 ]. The BL PAni commences presenting decomposition from 178 °C and degradation to 283 °C, according to the results of the TGA.…”

Biodegradable Conducting Polymer-Based Composites for Biomedical Applications—A Review

“…It might, therefore, be utilized as a powerful antibacterial and antistatic agent. Balitaan et al (2020) [ 149 ] synthesized β-chitin-g-PANI composites through the in situ graft copolymerization of β-chitin with conducting PANI. The study findings demonstrated enhanced antibacterial properties, biodegradability, and conductivity in the composites.…”

A double cross-linked hydrogel based on water-soluble chitosan and oxidized hyaluronic acid as an antibacterial dressing

“…16,17 But excessive use of antibiotics may lead to bacterial resistance. 18 As alternatives to antibiotics, various types of metal-based nanoparticles are incorporated into hydrogels to prevent and suppress bacterial infections. 19,20 However, metal-based nanoparticles have potential biological toxicity as they tend to accumulate and spread uncontrollably in the human body.…”