Rev-erbα agonists suppresses TGFβ1-induced fibroblast-to-myofibroblast transition and pro-fibrotic phenotype in human lung fibroblasts

PRASAD, C. S. G.; Hahn, Kameron; Duraisamy, S.K.; Salathé, Matthias; Burris, Thomas P.; Sundar, Isaac K.

doi:10.1016/j.bbrc.2023.05.092

Cited by 5 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…123 Conversely, REV-ERBα agonists suppress TGF-β1 (transforming growth factor β1)-induced fibroblast-tomyofibroblast transition and profibrotic phenotype. 124,125 Consistent with the knowledge that the CLOCK/BMAL1 heterodimer is immediately upstream of REV-ERBα, mice deficient for BMAL1 in the proximal tubule exhibit increased renal fibrosis in response to stress. 126 Collectively, these observations highlight that critical fibroblast functions are under circadian control.…”

Section: Compendium: Circadian Mechanisms In Cardio/ Cerebrovascular ...mentioning

confidence: 69%

Circadian Rhythms in Cardiovascular Metabolism

Lal,

Verma,

Wang

et al. 2024

Circulation Research

View full text Add to dashboard Cite

Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional parameters, including blood pressure, heart rate, and myocardial contractility. It is, therefore, not surprising that metabolic processes also fluctuate over the course of the day, to ensure temporal needs for ATP, building blocks, and metabolism-based signaling molecules are met. What has become increasingly clear is that in addition to classic signal-response coupling (termed reactionary mechanisms), cardiovascular-relevant cells use autonomous circadian clocks to temporally orchestrate metabolic pathways in preparation for predicted stimuli/stresses (termed anticipatory mechanisms). Here, we review current knowledge regarding circadian regulation of metabolism, how metabolic rhythms are synchronized with cardiovascular function, and whether circadian misalignment/disruption of metabolic processes contribute toward the pathogenesis of cardiovascular disease.

show abstract

Section: Compendium: Circadian Mechanisms In Cardio/ Cerebrovascular ...mentioning

confidence: 69%

Circadian Rhythms in Cardiovascular Metabolism

Lal,

Verma,

Wang

et al. 2024

Circulation Research

View full text Add to dashboard Cite

show abstract

“…In a mouse model of bleomycin-induced pulmonary fibrosis, it was observed that the REV-ERBα protein, involved in circadian cycle regulation, inhibited the fibrotic response triggered by TGFβ. Conversely, the suppression of REV-ERBα promoted fibroblastto-myofibroblast (FTM) differentiation, driving fibrosis [126], while REV-ERBα agonists prevented TGFβ-induced FTM, reduced the IL-6 levels, and reduced the expression of extracellular matrix (ECM) genes [127]. In mice, bleomycin exposure lowered the REV-ERBα levels, which was reverted with a REV-ERBα agonist (SR9009), and prevented collagen overexpression, while influenza A virus (IAV) infection increased the collagen and lysyl oxidase levels, which was prevented by a REV-ERBα agonist (GSK4112) [128].…”

Section: Idiopathic Pulmonary Fibrosismentioning

confidence: 99%

Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases

Castillejos-López,

Romero,

Varela-Ordoñez

et al. 2023

Cells

View full text Add to dashboard Cite

The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body’s tissues and helps regulate various processes such as sleeping, eating, and others. Interestingly, animal models have provided enough evidence to assume that the alteration in the circadian system leads to the appearance of numerous diseases. Alterations in breathing patterns in lung diseases can modify oxygenation and the circadian cycles; however, the response mechanisms to hypoxia and their relationship with the clock genes are not fully understood. Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulate the circadian cycles, the latter because hypoxia alters the production of melatonin and brain physiology. Additionally, the lack of oxygen alters the expression of clock genes, leading to an alteration in the regularity and precision of the circadian cycle. In this sense, hypoxia is a hallmark of a wide variety of lung diseases. In the present work, we intended to review the functional repercussions of hypoxia in the presence of asthma, chronic obstructive sleep apnea, lung cancer, idiopathic pulmonary fibrosis, obstructive sleep apnea, influenza, and COVID-19 and its repercussions on the circadian cycles.

show abstract

Cordyceps sinensis ameliorates idiopathic pulmonary fibrosis in mice via inhibiting mitochondrion‐mediated oxidative stress

Zhang,

Zhou,

Cheng

et al. 2024

MedComm – Future Medicine

View full text Add to dashboard Cite

Idiopathic pulmonary fibrosis (IPF) represents a chronic interstitial lung disease with an unclear underlying mechanism and currently lacks a definitive treatment. Cordyceps sinensis (CS), renowned for its pharmacological properties in traditional Chinese medicine and extensive use in lung disease treatment, holds promise as a therapeutic agent for IPF. However, the specific role of CS in treating IPF remains unclear. In this study, we aimed to assess the efficacy of CS in treating IPF and unravel potential underlying mechanisms. Our results demonstrate that CS treatment effectively mitigated pulmonary inflammation and collagen deposition in bleomycin‐induced IPF mice. Proteomics analysis revealed that the regulation of mitochondrial oxidative phosphorylation may serve as a potential protective mechanism of CS against IPF in mice. Further investigation unveiled that CS could suppress the excessive production of mitochondrial reactive oxygen species in lung tissues induced by bleomycin through moderating the expression and activity of mitochondrial complexes, thus safeguarding the integrity and function of mitochondria. Overall, our findings not only underscore the effectiveness of CS in preventing bleomycin‐induced IPF but also highlight mitochondrial‐mediated oxidative stress as a promising therapeutic target for treating IPF.

show abstract

Rev-erbα agonists suppresses TGFβ1-induced fibroblast-to-myofibroblast transition and pro-fibrotic phenotype in human lung fibroblasts

Cited by 5 publications

References 26 publications

Circadian Rhythms in Cardiovascular Metabolism

Circadian Rhythms in Cardiovascular Metabolism

Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases

Cordyceps sinensis ameliorates idiopathic pulmonary fibrosis in mice via inhibiting mitochondrion‐mediated oxidative stress

Contact Info

Product

Resources

About