Reusable surface-enhanced Raman substrates using microwave annealing

Papadakis, Vassilis; Kenanakis, George

doi:10.1007/s00339-018-2300-3

Cited by 7 publications

(5 citation statements)

References 50 publications

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“…An illustration of the designed reuse cycle of the Ag sheet is shown in Figure A, which can be used at least 20 times with slight changes of SERS intensity after a few minutes of ultrasonic cleaning in water, showing a promising prospect in the recyclable detection of pesticides. Papadakis and Kenanakis prepared the large-scale homogeneous silver SERS substrates, and the process of reuse was conducted by ultrasonic sonication in isopropyl alcohol and acetone for 15 min, respectively. By this way, the substrate could be efficiently reused for more than six times after sonication.…”

Section: Chemical-assisted Cleaning To Reuse Sers Substratesmentioning

confidence: 99%

Recyclable Surface-Enhanced Raman Scattering Substrate-Based Sensors for Various Applications

Zhang

Yang

Zhao

et al. 2023

ACS Sustainable Chem. Eng.

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Surface enhanced Raman scattering (SERS) has been widely used for detection and characterization benefiting from its high sensitivity and selectivity (molecular fingerprint information). However, the strong adsorption of target molecules (“memory effect”) on the nanoparticle surface inherently limits the recycle of SERS substrates. This paper focuses on the different strategies to achieve recyclable SERS substrates and their applications. First, the problems of nonrecyclable SERS substrates are discussed systematically. Then, two categories are summarized to achieve recyclable SERS substrates and their applications: (1) chemical-free cleaning methods (including photocatalytic degradation, thermal cleaning, and plasma treatment) and (2) chemical-assisted cleaning methods (including solvent washing, chemical reaction, and electrochemistry). Moreover, we put forward current challenges and potential strategies of recyclable SERS substrates.

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Section: Chemical-assisted Cleaning To Reuse Sers Substratesmentioning

confidence: 99%

Recyclable Surface-Enhanced Raman Scattering Substrate-Based Sensors for Various Applications

Zhang

Yang

Zhao

et al. 2023

ACS Sustainable Chem. Eng.

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“…In addition, analysis of cells and tissues is non-disruptive, especially from water molecules and it can be quanti ed and performed in situ [19]. Moreover, recently established techniques for enhancement of Raman scattering can increase the signal to noise ratio with the use of nanoparticles like surface-enhanced Raman scattering [20][21][22] or laser excitation frequency like resonance Raman scattering [23]. Different biomolecules have been analysed with the use of Raman spectroscopy, like chromosomes and single living cells [24], extracellular matrix [25], human blood cells [26-28], lymphocytes [29], mammalian cell cultures [30], cancer cells but also tissues like cervical tissue [31] and epithelial tissue [32].…”

Section: Introductionmentioning

confidence: 99%

Label-free human-disease characterization through circulating cell free DNA analysis using Raman Spectroscopy

Papadakis,

Cheimonidi,

Panagopoulou

et al. 2023

Preprint

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Circulating cell free DNA (ccfDNA) is a liquid biopsy biomaterial attracting significant attention for the implementation of precision medicine diagnostics. Deeper knowledge related to its structure and biology would enable the development of such applications. In this study, we employ Raman Spectroscopy to unravel the biomolecular profile of human ccfDNA in health and disease. We established reference Raman spectra of ccfDNA samples from healthy males and females, from different conditions including cancer and diabetes, extracting information about their chemical composition. Comparative observations showed a distinct spectral pattern in ccfDNA from breast cancer patients taking neoadjuvant therapy. Raman analysis of ccfDNA from healthy, prediabetic and diabetic males uncovered some differences in their biomolecular fingerprint. We also studied ccfDNA released from human benign and cancer cell lines and compared it to their respective gDNA, confirming mirroring its cellular origin. Overall, we explored for the first time Raman Spectroscopy in the study of ccfDNA and provide spectra of samples from different sources. Our findings introduce Raman Spectroscopy as a new approach to implementing liquid biopsy diagnostics worthing further elaboration.

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“…In addition, the analysis of cells and tissues is nondisruptive, especially from water molecules, and it can be quantified and performed in situ [19]. Moreover, recently established techniques for the enhancement of Raman scattering can increase the signal-to-noise ratio with the use of nanoparticles, such as surface-enhanced Raman scattering [20][21][22], or laser excitation frequency, such as resonance Raman scattering [23]. Different biomolecules have been analyzed with the use of Raman spectroscopy, such as chromosomes and single living cells [24], extracellular matrix [25], human blood cells [26][27][28], lymphocytes [29], mammalian cell cultures [30], and cancer cells but also tissues, such as cervical tissue [31] and epithelial tissue [32].…”

Section: Introductionmentioning

confidence: 99%

Label-Free Human Disease Characterization through Circulating Cell-Free DNA Analysis Using Raman Spectroscopy

Papadakis

Cheimonidi

Παναγοπούλου

et al. 2023

IJMS

Self Cite

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Circulating cell-free DNA (ccfDNA) is a liquid biopsy biomaterial attracting significant attention for the implementation of precision medicine diagnostics. Deeper knowledge related to its structure and biology would enable the development of such applications. In this study, we employed Raman spectroscopy to unravel the biomolecular profile of human ccfDNA in health and disease. We established reference Raman spectra of ccfDNA samples from healthy males and females with different conditions, including cancer and diabetes, extracting information about their chemical composition. Comparative observations showed a distinct spectral pattern in ccfDNA from breast cancer patients taking neoadjuvant therapy. Raman analysis of ccfDNA from healthy, prediabetic, and diabetic males uncovered some differences in their biomolecular fingerprints. We also studied ccfDNA released from human benign and cancer cell lines and compared it to their respective gDNA, confirming it mirrors its cellular origin. Overall, we explored for the first time Raman spectroscopy in the study of ccfDNA and provided spectra of samples from different sources. Our findings introduce Raman spectroscopy as a new approach to implementing liquid biopsy diagnostics worthy of further elaboration.

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Reusable surface-enhanced Raman substrates using microwave annealing

Cited by 7 publications

References 50 publications

Recyclable Surface-Enhanced Raman Scattering Substrate-Based Sensors for Various Applications

Recyclable Surface-Enhanced Raman Scattering Substrate-Based Sensors for Various Applications

Label-free human-disease characterization through circulating cell free DNA analysis using Raman Spectroscopy

Label-Free Human Disease Characterization through Circulating Cell-Free DNA Analysis Using Raman Spectroscopy

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