Reusable 3D Printed Ex-vivo Brain Enclosure and Two-Piece Cutting Guide for Axial and Coronal MRI Registration with Gross Anatomy Photographs

Berardinelli, Jacob; Kofler, Julia; Schweitzer, Noah; Farhat, Nadim; Santini, Tales; Sajewski, Andrea; Mettenburg, Joseph; Ikonomović, Miloš D.; Aizenstein, Howard; Ibrahim, Tamer S.

doi:10.58530/2022/2431

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“…The postmortem interval was 15 hours. The left hemisphere was fixed in 4% paraformaldehyde for three weeks and subsequently embedded in 1.5% (w/v) agar (Millipore Sigma, A5431) and 30% sucrose (Fisher, S5-3) hydrogel [33] in a 3D printed container [34][35][36] for postmortem MRI scanning. This scanning process utilized a 7T human MRI scanner (Siemens, Germany), featuring a custom-built radiofrequency Tic-Tac-Toe head coil system equipped with 16 transmit channels and 32 receive channels [37][38][39].…”

Section: Methodsmentioning

confidence: 99%

A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable

Liou,

Lou,

Nakagiri

et al. 2024

Preprint

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In this neuropathology case report, we present findings from an individual with Down syndrome (DS) who remained cognitively stable despite Alzheimer’s disease (AD) neuropathology. Clinical assessments, fluid biomarkers, neuroimaging, and neuropathological examinations were conducted to characterize her condition. Notably, her ApoE genotype was E2/3, which is associated with a decreased risk of dementia. Neuroimaging revealed stable yet elevated amyloid profiles and moderately elevated tau levels, while neuropathology indicated intermediate AD neuropathologic change with Lewy body pathology and cerebrovascular pathology. Despite the presence of AD pathology, the participant demonstrated intact cognitive functioning, potentially attributed to factors such as genetic variations, cognitive resilience, and environmental enrichment. The findings suggest a dissociation between clinical symptoms and neuropathological changes, emphasizing the complexity of AD progression in DS. Further investigation into factors influencing cognitive resilience in individuals with DS, including comorbidities and social functioning, is warranted. Understanding the mechanisms underlying cognitive stability in DS could offer insights into resilience to AD neuropathology in people with DS and in the general population and inform future interventions.

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Section: Methodsmentioning

confidence: 99%

A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable

Liou,

Lou,

Nakagiri

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Reusable 3D Printed Ex-vivo Brain Enclosure and Two-Piece Cutting Guide for Axial and Coronal MRI Registration with Gross Anatomy Photographs

Abstract: A 3D printed re-usable box enclosure and two-piece cutting guide were developed to produce high quality 7T MR images that can be easily registered to gross anatomy and histology. Cuts can be made parallel or at multiple angles at 5mm intervals in both the axial and coronal orientations.

Cited by 1 publication

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A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable

A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable

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