Return to work after young stroke: A systematic review

Edwards, Jodi D.; Kapoor, Arunima; Linkewich, Elizabeth; Swartz, Richard H.

doi:10.1177/1747493017743059

Cited by 130 publications

(155 citation statements)

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“…Most patients with stroke survive the acute episode and live with enduring disability. Upper limb paresis in particular is one of the most common long‐term disabilities after stroke and constitutes one, if not the most limiting factor in the reintegration to daily life and return to work . Effective therapies to improve motor function after stroke are yet to be developed.…”

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confidence: 99%

“…Upper limb paresis in particular is one of the most common long-term disabilities after stroke 1 and constitutes one, if not the most limiting factor in the reintegration to daily life 2 and return to work. 3,4 Effective therapies to improve motor function after stroke are yet to be developed. Therapies targeting restorative processes encompass brain stimulation techniques.…”

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confidence: 99%

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Low‐Frequency Brain Oscillations Track Motor Recovery in Human Stroke

Bönstrup

Krawinkel

Schulz

et al. 2019

Annals of Neurology

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Objective The majority of patients with stroke survive the acute episode and live with enduring disability. Effective therapies to support recovery of motor function after stroke are yet to be developed. Key to this development is the identification of neurophysiologic signals that mark recovery and are suitable and susceptible to interventional therapies. Movement preparatory low‐frequency oscillations (LFOs) play a key role in cortical control of movement. Recent animal data point to a mechanistic role of motor cortical LFOs in stroke motor deficits and demonstrate neuromodulation intervention with therapeutic benefit. Their relevance in human stroke pathophysiology is unknown. Methods We studied the relationship between movement‐preparatory LFOs during the performance of a visuomotor grip task and motor function in a longitudinal (<5 days, 1 and 3 months) cohort study of 33 patients with motor stroke and in 19 healthy volunteers. Results Acute stroke–lesioned brains fail to generate the LFO signal. Whereas in healthy humans, a transient occurrence of LFOs preceded movement onset at predominantly contralateral frontoparietal motor regions, recordings in patients revealed that movement‐preparatory LFOs were substantially diminished to a level of 38% after acute stroke. LFOs progressively increased at 1 and 3 months. This re‐emergence closely tracked the recovery of motor function across several movement qualities including grip strength, fine motor skills, and synergies and was frequency band specific. Interpretation Our results provide the first human evidence for a link between movement‐preparatory LFOs and functional recovery after stroke, promoting their relevance for movement control. These results suggest that it may be interesting to explore targeted, LFOs‐restorative brain stimulation therapy in human stroke patients. ANN NEUROL 2019;86:853–865

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confidence: 99%

mentioning

confidence: 99%

Low‐Frequency Brain Oscillations Track Motor Recovery in Human Stroke

Bönstrup

Krawinkel

Schulz

et al. 2019

Annals of Neurology

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“…5,10,27,28 However, men and women were functionally independent at discharge RTW in a similar pattern. 5,10,27,28 However, men and women were functionally independent at discharge RTW in a similar pattern.…”

Section: Discussionmentioning

confidence: 90%

“…10,11 Further, the RTW varied depending on occupational groups. This finding is in line with previous literature reviews based on self-reported RTW.…”

Section: Discussionmentioning

confidence: 99%

Work‐related predictors for return to work after stroke

et al. 2019

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Objectives Disability due to stroke imposes a large burden on individuals, and on society, in terms of impaired work ability and sick leave. The reported return to work (RTW) rate after stroke varies globally and is influenced by a range of different aspects. The aim of this study was to investigate the influence of work‐related factors on time to RTW after stroke, and possible differences between the sexes. Materials & Methods Data from 204 persons with first‐time stroke in the years 2009‐2010 in Gothenburg, Sweden, who were of working age and had worked prior to their stroke, were analysed. Disease‐related characteristics were retrieved from medical records, and work‐related‐ and socio‐economic data were collected up to 6 years post‐stroke from Statistics Sweden and the Swedish Social Insurance Agency. Cox regression was used to analyse predictors for time to RTW. Results We identified qualified occupation and large organizational size as work‐related predictors for shorter time to RTW after stroke. Being male predicted a faster and higher frequency of RTW. Qualified occupation predicted shorter time to RTW in men but not in women. For women, the only predictor for RTW was physical dependency at discharge. Conclusion Type of work and organizational size are work‐related factors of importance for RTW after stroke. Work‐related factors were important for RTW in men, but not in women. Reasons for differences between men and women in work‐related factors that influence RTW need to be further investigated to better understand how to support women in the RTW process.

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“…Edwards, Kapoor, Linkewich and Swartz () aimed to investigate who was most likely to return to work after stroke, and what factors were associated with this outcome. Although the authors nominated the review's cohort as “young stroke”, the criteria included adult survivors of working aged between 18 and 64 years, consistent with the Global Burden of Disease (Krishnamurthi et al ., ), and a mean, between‐study age ranging from 37 to 55 years.…”

Section: Commentarymentioning

confidence: 99%