Return of fertility in nulliparous and parous women after levonorgestrel 52 mg intrauterine system discontinuation

Carr, Bruce R.; Thomas, Michael A.; Gangestad, Angelina; Eisenberg, DL; Olariu, Andrea I.; Creinin, Mitchell D.

doi:10.1016/j.fertnstert.2018.07.145

Cited by 2 publications

(1 citation statement)

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“…There is still relatively little data in the available literature regarding the long-term safety of IUD use, especially regarding fertility. Nevertheless, those available do not indicate an increased risk of infertility [59,60].…”

Section: Other Side Effectsmentioning

confidence: 96%

Levonorgestrel-Releasing Intrauterine System as a Contraceptive Method in Nulliparous Women: A Systematic Review

Zgliczyńska

Kocaj

Szymusik

et al. 2020

JCM

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The aim of this review was to summarize the available evidence about the use of levonorgestrel-releasing intrauterine system (LNG-IUS) as a contraceptive method in nulliparous women. For this purpose, studies evaluating the efficacy, safety, bleeding pattern, satisfaction and discontinuation of the levonorgestrel-releasing intrauterine system in nulliparous women were analyzed. Only original research articles published in English between 1990–27th March 2020 were considered eligible. Reviews, book chapters, case studies, conference papers, opinions, editorials and letters were excluded. The systematic literature search of PubMed/MEDLINE, Scopus, Embase and Cochrane Library databases identified 816 articles, 23 of which were analyzed. The available evidence indicates that LNG-IUS is an effective and safe contraceptive method for nulliparous women that achieves high levels of satisfaction among patients. Moreover, nulliparous women seem to experience fewer expulsions than parous ones. Bleeding pattern is acceptable for the majority of patients, and bleeding disorders mainly occur in the first months after the insertion. More in-depth, long-term prospective studies are needed in this patient group to determine risk factors for the occurrence of side effects and associated discontinuations, which should not, however, delay the wider use of the method in this group, given the number of advantages.

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Section: Other Side Effectsmentioning

confidence: 96%