Retroviruses and autoimmune rheumatic diseases

Kalden, Joachim R.

doi:10.1111/j.1365-2249.1994.tb06597.x

Cited by 48 publications

(1 citation statement)

References 49 publications

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“…Retroviruses have been discussed as important etiologic factors in autoimmune rheumatic diseases (1). Human Tlymphotropic virus type 1 (HTLV-I) is the causative agent of adult T cell lymphoma/leukemia and HTLV-I-myelopathy/ tropical spastic paraparesis (HAM/TSP) (2,3).…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of HTLV-1-Related Overlap Syndrome Using Tacrolimus

et al. 2011

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A 56-year-old HTLV-I-positive woman, initially diagnosed as having Sjögren's syndrome, presented with muscle weakness, myalgia, face erythema and leg edema. Based on the presence of various autoantibodies, the diagnosis of overlap syndrome (dermatomyositis/Sjögren's syndrome) was made. Treatment with highdose corticosteroid plus cyclosporine improved her symptoms. However, three months after the start of these treatments, exacerbation of myositis occurred. A muscle biopsy revealed prominent perivascular accumulation of mononuclear cells with perifascicular atrophy, which were consistent with dermatomyositis. Tacrolimus, which was substituted for cyclosporine led to marked improvement of the myositis symptoms.

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Section: Introductionmentioning

confidence: 99%

Successful Treatment of HTLV-1-Related Overlap Syndrome Using Tacrolimus

et al. 2011

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Hormonal, environmental, and infectious risk factors for developing systemic lupus erythematosus

Cooper

Dooley

Treadwell

et al. 1998

Arthritis & Rheumatism

192

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?Lymphoid? chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sj�gren's syndrome patients: Possible participation in lymphoid structure formation

Xanthou¹,

Polihronis²,

Tzioufas³

et al. 2001

Arthritis & Rheumatism

141

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Objective Many studies have shown that the microanatomic organization of infiltrating leukocytes in the salivary gland lesions of patients with Sjögren's syndrome (SS) resembles the structure of lymphoid organs. A newly defined set of chemokines referred to as “lymphoid,” which orchestrate leukocyte microenvironmental homing and contribute to the formation of lymphoid structures, provides directional clues. The aim of this study was to investigate the possible existence of “lymphoid” chemokines in the chronic inflammatory lesions of SS patients and thus validate their potential involvement in the disease process. Methods Twelve patients with primary SS, 3 patients with secondary SS, 4 patients with other autoimmune disorders, and 4 control individuals were the subjects of this study. Reverse transcriptase–polymerase chain reaction analysis was performed in order to examine the messenger RNA (mRNA) expression of “lymphoid” chemokines. Furthermore, in situ hybridization studies revealed chemokine mRNA localization. Immunohistochemistry was also applied in order to identify the cell types that expressed the chemokine mRNA. Results STCP‐1/monocyte‐derived chemokine and TARC mRNA were expressed in the majority of patients with primary and secondary SS, in 2 of 4 patients with other autoimmune disorders, and in 2 of 4 controls. BCA‐1, ELC, and PARC mRNA were only detected in patients with primary and secondary SS. SLC mRNA was also detected in 1 non‐SS patient. The main cellular sources of chemokine mRNA were ductal epithelial cells and infiltrating mononuclear leukocytes. Conclusion The expression pattern of “lymphoid” chemokine mRNA points further to the role of epithelial cells in the pathogenesis of SS and offers new insight into the potential mechanisms that could be involved in leukocyte attraction and in the in situ formation of secondary lymphoid tissue structures.

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Retroviruses and autoimmune rheumatic diseases

Cited by 48 publications

References 49 publications

Successful Treatment of HTLV-1-Related Overlap Syndrome Using Tacrolimus

Successful Treatment of HTLV-1-Related Overlap Syndrome Using Tacrolimus

Hormonal, environmental, and infectious risk factors for developing systemic lupus erythematosus

?Lymphoid? chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sj�gren's syndrome patients: Possible participation in lymphoid structure formation

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