Retrosplenial cortex lesions impair acquisition of active avoidance while sparing fear-based emotional memory

Lukoyanov, Nikolay; Lukoyanova, Elena A.

doi:10.1016/j.bbr.2006.06.026

Cited by 40 publications

(44 citation statements)

References 44 publications

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“…Other animal studies have identified the retrosplenial cortex as being involved in emotional behavior, particularly associated with response to unfamiliar stimuli. Indeed, lesions of the retrosplenial cortex of rats results in increased anxiety and an impaired active avoidance response (Lukoyanov and Lukoyanova, 2006). Thus, in light of these previous studies, our findings suggest that the retrosplenial cortex has a role in a broader range of chronic pain syndromes.…”

Section: Discussionmentioning

confidence: 99%

Lower Functional Connectivity of the Periaqueductal Gray Is Related to Negative Affect and Clinical Manifestations of Fibromyalgia

et al. 2017

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Fibromyalgia (FM) syndrome is characterized by chronic widespread pain, muscle tenderness and emotional distress. Previous studies found reduced endogenous pain modulation in FM. This deficiency of pain modulation may be related to the attributes of chronic pain and other clinical symptoms experienced in patients with FM. Thus, we tested whether there is a link between the clinical symptoms of FM and functional connectivity (FC) of the periaqueductal gray (PAG), a key node of pain modulation. We acquired resting state 3T functional MRI (rsfMRI) data from 23 female patients with FM and 16 age- and sex- matched healthy controls (HC) and assessed FM symptoms with the Brief Pain Inventory (BPI), Fibromyalgia Impact Questionnaire (FIQ), Hospital Anxiety and Depression Scale (HADS) and Pain Catastrophizing Scale (PCS). We found that patients with FM exhibit statistically significant disruptions in PAG FC, particularly with brain regions implicated in negative affect, self-awareness and saliency. Specifically, we found that, compared to HCs, the FM patients had stronger PAG FC with the lingual gyrus and hippocampus but weaker PAG FC with regions associated with motor/executive functions, the salience (SN) and default mode networks (DMN). The attenuated PAG FC was also negatively correlated with FIQ scores, and positively correlated with the magnification subscale of the PCS. These alterations were correlated with emotional and behavioral symptoms of FM. Our study implicates the PAG as a site of dysfunction contributing to the clinical manifestations and pain in FM.

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Section: Discussionmentioning

confidence: 99%

Lower Functional Connectivity of the Periaqueductal Gray Is Related to Negative Affect and Clinical Manifestations of Fibromyalgia

et al. 2017

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“…For instance, Wistar rats subjected to a blast peak overpressure of 340 kPa performed 50% worse in the active-avoidance response test relative to non-exposed controls (Cernak et al, 2001). This suggests that the rats may have suffered damage to the retrosplenial cortex (part of the cingulate cortex) of the brain during blast, where deficits in memory may result in an inability to perform efficiently on avoidance tasks (Lukoyanov and Lukoyanova, 2006). Another group conducted electroencephalographic (EEG) experiments in blast-treated rats and observed non-epileptiform abnormalities characterized by reductions in both amplitude and frequency of the EEG (Risling et al, 2002).…”

Section: Introductionmentioning

confidence: 89%

Effect of Blast Exposure on the Brain Structure and Cognition inMacaca fascicularis

Ling

et al. 2012

Journal of Neurotrauma

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Blast injury to the brain is one of the major causes of death and can also significantly affect cognition and physical and psychological skills in survivors of blast. The complex mechanisms via which blast injury causes impairment of cognition and other symptoms are poorly understood. In this study, we investigated the effects of varying degrees of primary blast overpressure (BOP; 80 and 200 kPa) on the pathophysiological and magnetic resonance imaging (MRI) changes and neurocognitive performance as assessed by the monkey Cambridge Neuropsychological Test Automated Battery (mCANTAB) in non-human primates (NHP). The study aimed to examine the effects of neurobehavioral and histopathological changes in NHP. MRI and histopathology revealed ultrastructural changes in the brain, notably in the Purkinje neurons in the cerebellum and pyramidal neurons in the hippocampus, which were most vulnerable to the blast. The results correlated well with the behavioral changes and changes in motor coordination and working memory of the affected monkeys. In addition, there was white matter damage affecting myelinated axons, astrocytic hypertrophy, and increased aquaporin-4 (AQP-4) expression in astrocytes, suggesting cerebral edema. Increased apoptosis appeared to involve astrocytes and oligodendrocytes in the animals following blast exposure. The small sample size could have contributed to the non-significant outcome in cognitive performance post-blast and limited quantitative analyses. Nevertheless, the study has provided initial descriptive changes for establishing a primary BOP threshold for brain injury to serve as a useful platform for future investigations that aim to estimate brain injury potential and set safe limits of exposure.

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“…Animals were handled 3 minutes per day during 5 days and subjected to the open-field test and plus-maze as previously described in detail [20]. The rats were counterbalanced so that, in each group, half received the open-field test first and the other half received the plus-maze test first.…”

Section: Methodsmentioning

confidence: 99%

Loss of Hippocampal Neurons after Kainate Treatment Correlates with Behavioral Deficits

et al. 2014

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Treating rats with kainic acid induces status epilepticus (SE) and leads to the development of behavioral deficits and spontaneous recurrent seizures later in life. However, in a subset of rats, kainic acid treatment does not induce overt behaviorally obvious acute SE. The goal of this study was to compare the neuroanatomical and behavioral changes induced by kainate in rats that developed convulsive SE to those who did not. Adult male Wistar rats were treated with kainic acid and tested behaviorally 5 months later. Rats that had experienced convulsive SE showed impaired performance on the spatial water maze and passive avoidance tasks, and on the context and tone retention tests following fear conditioning. In addition, they exhibited less anxiety-like behaviors than controls on the open-field and elevated plus-maze tests. Histologically, convulsive SE was associated with marked neuron loss in the hippocampal CA3 and CA1 fields, and in the dentate hilus. Rats that had not experienced convulsive SE after kainate treatment showed less severe, but significant impairments on the spatial water maze and passive avoidance tasks. These rats had fewer neurons than control rats in the dentate hilus, but not in the hippocampal CA3 and CA1 fields. Correlational analyses revealed significant relationships between spatial memory indices of rats and neuronal numbers in the dentate hilus and CA3 pyramidal field. These results show that a part of the animals that do not display intense behavioral seizures (convulsive SE) immediately after an epileptogenic treatment, later in life, they may still have noticeable structural and functional changes in the brain.

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Retrosplenial cortex lesions impair acquisition of active avoidance while sparing fear-based emotional memory

Cited by 40 publications

References 44 publications

Lower Functional Connectivity of the Periaqueductal Gray Is Related to Negative Affect and Clinical Manifestations of Fibromyalgia

Lower Functional Connectivity of the Periaqueductal Gray Is Related to Negative Affect and Clinical Manifestations of Fibromyalgia

Effect of Blast Exposure on the Brain Structure and Cognition inMacaca fascicularis

Loss of Hippocampal Neurons after Kainate Treatment Correlates with Behavioral Deficits

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