Retrospective study of the efficacy of oral potassium supplementation in cats with kidney disease

Abstract

Objectives The aim of this study was to assess the effect of three oral potassium supplements (potassium gluconate tablets [PGT], potassium gluconate granules [PGG] and potassium citrate granules [PCG]) on hypokalemia and serum bicarbonate in cats with chronic kidney disease (CKD). Methods Medical records (2006–2016) were retrospectively searched for cats that had been prescribed an oral potassium supplement for management of their CKD-associated hypokalemia. For inclusion, laboratory work had to be available at the time of hypokalemia diagnosis, and at recheck within 1–6 weeks. Treatment response was defined in three ways: any increase in potassium, an increase in potassium to within the normal reference interval, and an increase to >4 mEq/l. Results Thirty-seven cats met inclusion criteria (16 PGT, 11 PGG, 10 PCG). Dosing ranged from 0.21 to 1.6 mEq/kg/day for PGT, from 0.25 to 1.48 mEq/kg/day for PGG and from 0.04 to 1.34 mEq/kg/day for PCG. After supplementation, 36/37 cats had an increase in potassium, 34/37 increased to within the reference interval and 24/37 had an increase in potassium to >4 mEq/l. There was a statistically significant difference in serum potassium post-supplementation for all three treatments: PGT ( P = 0.0001), PGG ( P = 0.001) and PCG ( P = 0.002). There was a positive correlation between PGT dose and change in potassium concentration ( P = 0.04), but there was no significant correlation for PGG or PCG. In cats that had data available, serum bicarbonate increased >2 mEq/l in 1/6 PGT, 1/6 PGG and 3/4 PCG cats. Conclusions and relevance All three potassium supplements were effective in treating hypokalemia secondary to CKD in the majority of cats despite variable dosing. Data were limited to assess the alkalinizing effect and prospective studies are needed.

Chronic kidney disease in cats

“…Vários fatores, incluindo idade, raça, vacinação, hipertensão, proteinúria e lesão renal aguda (LRA), estão implicados na patogênese. Com a falta de marcadores sensíveis precoces de diminuição da função renal, a DRC em gatos é frequentemente diagnosticada tardiamente em seu curso, quando o comprometimento funcional excede os mecanismos compensatórios e danos irreversíveis substanciais ao parênquima renal já ocorreram (Sieberg & Quimby, 2020).…”

Principais Características Fisiopatológicas e Tratamentos em Felinos com Doença Renal Crônica: uma Revisão

“…Vários fatores, incluindo idade, raça, vacinação, hipertensão, proteinúria e lesão renal aguda (LRA), estão implicados na patogênese da DRC. Com a falta de marcadores sensíveis precoces de diminuição da função renal, a DRC em gatos é frequentemente diagnosticada tardiamente em seu curso, quando o comprometimento funcional excede os mecanismos compensatórios e danos irreversíveis substanciais ao parênquima renal já ocorreram (SIEBERG; QUIMBY, 2020).…”