Retrospective Study of Interstitial Lung Disease in a Tertiary Care Centre in India

Sen, Tiyas; Udwadia, Zarir F

doi:10.5005/ijcdas-52-4-207

Cited by 29 publications

(11 citation statements)

References 7 publications

(5 reference statements)

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“…The available studies showed wide variations in the incidence and prevalence of the various ILDs among countries. [3][4][5][6][7] The spectrum of ILDs varies from country to country, within a country; and depends upon genetic factor, environmental factors, occupational exposures, smoking habits, socio-cultural and farming practices. [8][9] Recently, a multi-centre study 10 in India showed hypersensitivity as most common ILD in contrary to other studies 5,[11][12] which showed sarcoidosis and connective tissue disease related ILD (CTD-ILD) as the most common ILD.…”

Section: Introductionmentioning

confidence: 99%

Clinical Profile of Interstitial Lung Disease at a Tertiary Care Centre in India

Kumar¹,

Kumar²,

Kumar³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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Background. The prevalence and spectrum of interstitial lung diseases (ILDs) varies from region to region depending upon genetic and environmental factors.Methods. This was a descriptive observational study of 262 consecutive ILD patients diagnosed in the Pulmonary Medicine Department over a period of four years.Results. The mean age of the patient was 52.7±14.9 years; there were 120 males. All types of ILDs were more common in women except idiopathic pulmonary fibrosis (IPF) which was found predominantly (90.6%) in male patients. High resolution computed tomography (HRCT) showed definite usual interstitial pneumonia (UIP), possible UIP and inconsistent with UIP patterns in 50.4%, 9.5% and 40.1%, respectively. IPF was the most commonly found ILD (24.1%) followed by connective tissue disease related ILD (CTD-ILD) (22.1%), non-specific interstitial pneumonia (NSIP) (17.2%), hypersensitivity pneumonitis (HSP) (15.6%), sarcoidosis (7.6%), combined pulmonary fibrosis and emphysema (CPFE) (4.6%), cryptogenic organising pneumonia (4.2%), and occupational lung disease (2.7%), respectively. Bronchoscopic procedures were performed in 66 (25.2%) of patients which were diagnostic in 27 (44.9%); overall pathological diagnosis was possible in 10.2%. Univariate analysis showed smoking and hypothyroidism as statistically significant risk factors associated with IPF.Conclusions. Idiopathic pulmonary fibrosis was found as most common ILD; UIP pattern was seen in IPF, CTD-ILDs, chronic HSP and fibrotic NSIP.

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Section: Introductionmentioning

confidence: 99%

Clinical Profile of Interstitial Lung Disease at a Tertiary Care Centre in India

Kumar¹,

Kumar²,

Kumar³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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“…In 2004, Subhash et al 16 published a series of 97 patients with DPLD; and IPF was present in 45% of the patients. In 2010, Sen et al 17 reported a series of 274 patients with biopsy proven ILD over a period of six years, probably the largest series from India so far, and IPF was found in 43% of cases. Thus, similar to the western world, among the different ILD patients, IPF is the major disease that has been reported in the Indian studies.…”

Section: Editorialmentioning

confidence: 99%

The ILD India Registry: A Novel Tool for Epidemiological Surveillance of Interstitial Lung Disease in India

Singh¹,

Sharma²

2022

The Indian Journal of Chest Diseases and Allied Sciences

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“…The Indian Journal of Chest Diseases & Allied Sciences 105 4. Macitentan: No effect on pulmonary function or time to worsening of disease or death 135 5.…”

Section: ;Vol60mentioning

confidence: 99%

“…3 The proportion of patients with IPF among all patients with ILD has been variably reported between 13% and 44% in different studies from India. [4][5][6][7] Of late, there has been a renewed interest in IPF in the international pulmonary research community. [8][9][10][11] There are important gaps in the knowledge of physicians on IPF, especially in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Consensus Statement for the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis in Resource Constrained Settings

Guleria¹,

Chaudhry²,

Singh³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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Background. Idiopathic pulmonary fibrosis (IPF) is a specific type of chronic fibrosing interstitial lung disease (ILD) that is progressive in course. Although evidence-based guidelines for IPF are available, these are difficult to interpret for the average physician and may not be suitable for use in resource-constrained settings. There was an unmet need to formulate guidelines that are pragmatic, easy to understand and suited for application in resource-limited settings.Methods. This statement was made by a group of expert pulmonologists. Twenty-five questions regarding diagnosis and management of IPF were framed. A literature search was conducted using the PubMed and EmBase databases. The expert group discussed available evidence relevant to each question and recommendations were arrived at by consensus. Results.A thorough clinical and laboratory evaluation should be performed in patients suspected to have ILDs and potential underlying causes should be ruled out. A high resolution computed tomography (HRCT) of the chest is essential to identify the pattern of ILD. The need for a lung biopsy should be decided based on the appearance on the HRCT. Once a diagnosis of IPF is made, anti-fibrotic drugs (pirfenidone or nintedanib) should be offered after discussing the expected benefits and potential adverse effects with the patient. Recommendations have been made on other issues in the management of IPF, such as management of cough and dyspnoea, role of supplemental oxygen, mechanical ventilation and lung transplantation. Conclusion.This consensus statement provides practical and easy-to-use recommendations for the diagnosis and management of IPF in resource-limited settings.

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Retrospective Study of Interstitial Lung Disease in a Tertiary Care Centre in India

Cited by 29 publications

References 7 publications

Clinical Profile of Interstitial Lung Disease at a Tertiary Care Centre in India

Clinical Profile of Interstitial Lung Disease at a Tertiary Care Centre in India

The ILD India Registry: A Novel Tool for Epidemiological Surveillance of Interstitial Lung Disease in India

Consensus Statement for the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis in Resource Constrained Settings

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