Retrospective study of dilated cardiomyopathy in dogs

Freid, Kimberly J; Freeman, Lisa M.; Rush, John E.; Cunningham, Suzanne M.; Davis, Megan S; Karlin, Emily T; Yang, Vicky

doi:10.1111/jvim.15972

Cited by 37 publications

(94 citation statements)

References 22 publications

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“…The current study identified a substantial number of biochemical differences in the 3P/FDA diets, which have been associated with DCM in pet dogs, compared to non-3P/FDA diets 34,[40][41][42][43][44][45][46] . Most (81.9%) biochemical compounds that differed between diet groups were higher in 3P/FDA diets compared to non-3P/FDA diets, and www.nature.com/scientificreports/ four distinguishing ingredients, peas, lentils, chicken/turkey, and rice, which also differed across the diet groups, appear to contribute to these differences.…”

Section: Discussionmentioning

confidence: 99%

“…Other compounds that distinguished 3P/FDA and non-3P/FDA diet groups, such as the tetrasaccharide stachyose, are found in legumes but are not specific to peas 68,69 . Previous reports on ingredients that contribute to DCM in dogs have implicated pulses in general or specific pulses such as lentils or peas 34,35,43,44 . As of April 30, 2019, 89% of DCM-associated diets reported to the FDA contained peas and 93% of diets contained peas or lentils 43 .…”

Section: Discussionmentioning

confidence: 99%

“…Recent focus on the role of diet in DCM in dogs stems from veterinary reports and Food and Drug Administration (FDA) investigation of a potential link between certain diets and DCM in dogs 34,[40][41][42][43][44][45][46] . As of September, 2020, > 1100 dogs with DCM had been reported to the FDA 47 .…”

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confidence: 99%

“…One of the unique characteristics about the dogs with diet-associated DCM is their outcome. While DCM in dogs is usually a progressive disease with short survival times, multiple studies have shown that dogs with diet-associated DCM have significant echocardiographic improvement and longer survival time after diet change and medical treatment 34,40,[44][45][46] . The diets reported to be associated with DCM often are marketed as "grain-free" and often contain certain ingredients that became part of commercial foods relatively recently (e.g., pulses, potatoes, and sweet potatoes) and lack others (such as rice or corn).…”

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confidence: 99%

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Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis

Smith

Parnell

Lai

et al. 2021

Sci Rep

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Dilated cardiomyopathy (DCM) is a disease of the heart muscle that affects both humans and dogs. Certain canine diets have been associated with DCM, but the diet-disease link is unexplained, and novel methods are needed to elucidate mechanisms. We conducted metabolomic profiling of 9 diets associated with canine DCM, containing ≥ 3 pulses, potatoes, or sweet potatoes as main ingredients, and in the top 16 dog diet brands most frequently associated with canine DCM cases reported to the FDA (3P/FDA diets), and 9 non-3P/FDA diets. We identified 88 named biochemical compounds that were higher in 3P/FDA diets and 23 named compounds that were lower in 3P/FDA diets. Amino acids, amino acid-derived compounds, and xenobiotics/plant compounds were the largest categories of biochemicals that were higher in 3P/FDA diets. Random forest analyses identified the top 30 compounds that distinguished the two diet groups with 100% predictive accuracy. Four diet ingredients distinguished the two diet groups (peas, lentils, chicken/turkey, and rice). Of these ingredients, peas showed the greatest association with higher concentrations of compounds in 3P/FDA diets. Moreover, the current foodomics analyses highlight relationships between diet and DCM in dogs that can identify possible etiologies for understanding diet-disease relationships in dogs and humans.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis

Smith

Parnell

Lai

et al. 2021

Sci Rep

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“…Delaney et al (45) observed that the whole blood taurine concentration was lower in dogs fed whole grain rice, rice bran, or barley. Freid et al (46) in a retrospective study on dogs affected by dilatative myopathies, observed that dogs fed a non-traditional diet (grainfree contained novel ingredients such as peas or lentils as the main component) showed status improvement after their diet was changed. Donadelli et al (17) did not observe a reduction in plasma amino acids and taurine status when Labrador Retrievers were fed with a commercial grain-free diet after 26 weeks.…”

Section: Discussionmentioning

confidence: 99%

Clinical Findings in Healthy Dogs Fed With Diets Characterized by Different Carbohydrates Sources

et al. 2021

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In recent years, pet owners have become more interested in the ingredients, and quality of pet-food, and several studies have demonstrated that feed management could affect healthy status. Recently, some authors indicated that commercial diets formulated without cereals, or using unconventional protein, and starch sources, can cause a reduction in taurine levels in both whole blood, and plasma. Nevertheless, the specific mechanism by means of which nutritional factors determine this reduction is not completely clear. Thirty neutered half-breed dogs were recruited at a kennel in the province of Naples (Italy) to investigate the influence of carbohydrates sources, and dietary density of nutrients on healthy status of dogs in terms of blood count, and biochemical parameters. The dogs were housed in the kennel and divided into three distinct groups. Three iso-energy, and iso-nitrogen commercial kibble diets (named GF1, GF2, and CB) with different protein, and carbohydrates contents, and carbohydrates sources were chosen for the trial. The chemical composition and amino acid profile of each of the three tested diets were analyzed. Moreover, blood samples of each dog were collected to evaluate the hematological and biochemical profiles. The taurine level was determined both on plasma and whole blood. The effect of the diets was analyzed statistically, and all tested diets were compared to the control one. There were significant differences between the three tested diets as regards their chemical composition. The concentrations of all amino acids seem to reflect protein content diets. The hematological profile resulted within the ranges considered physiological for the canine species for all subjects. Compared to the control diet, the three tested diets showed significant differences in blood count for MCHC and platelets. The biochemical profile showed significant differences between the diets, particularly their AST, fructosamine, lipase, and triglycerides values. The diets did not affect the blood and plasma taurine levels. They resulted in higher than optimal reserve levels. Preliminary results showed that the sources of carbohydrates and use of balanced diets affected only some biochemical parameters and did not alter the levels of taurine in healthy adult dogs.

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Nutritional Management of Cardiovascular Diseases

Freeman,

Rush

2023

Applied Veterinary Clinical Nutrition

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Retrospective study of dilated cardiomyopathy in dogs

Abstract: Background: The United States Food and Drug Administration is investigating possible diet-associated dilated cardiomyopathy (DCM) in dogs and cats. Objectives: To retrospectively review DCM cases for signalment, diet information, echocardiographic changes, and survival.

Cited by 37 publications

References 22 publications

Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis

Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis

Clinical Findings in Healthy Dogs Fed With Diets Characterized by Different Carbohydrates Sources

Nutritional Management of Cardiovascular Diseases

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