Retrospective study of comparison of clinical severity and outcome of hospitalised COVID-19 patients during the first and second waves of the pandemic in India

Kundavaram, Abhilash; Selvan, Saravanan; Raja, V. Pragadeesh; Mathiyalagan, Ponnivalavan; Kanagarajan, Rohini; Reddy, Narmadha P; Rajendiran, Natarajan; Hazra, Darpanarayan; Gunasekaran, Karthik; Moorthy, Mahesh; Lenin, Audrin; Mathew, Divya Elizabeth; Iyyadurai, Ramya; Varghese, George; Dj, Christopher; Joy, Melvin; Peter, John Victor

doi:10.1136/bmjopen-2022-062724

Cited by 2 publications

(1 citation statement)

References 14 publications

(24 reference statements)

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“…However, it was lower in the fourth wave with 1.2%. It might be due to the vaccination effect among healthcare workers in the fourth wave, and the finding is similar to a retrospective study in India [17].…”

Section: Strobe: Strengthening the Reporting Of Observational Studies...supporting

confidence: 85%

Clinical Profile of COVID-19 Patients Admitted at a Private Hospital During Three Surges in Mandalay, Myanmar

Kyu¹,

Ko²,

Lwin³

et al. 2023

Cureus

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IntroductionDuring the coronavirus disease 2019 (COVID-19) pandemic, private hospitals in Mandalay started to manage COVID-19 infections according to national treatment guidelines since February 2021. Variations of clinical characteristics and their outcomes in different surges could be evaluated in the private hospital. This study aimed to assess the clinical profile and outcomes of COVID-19 patients admitted at a private hospital during three surges in Mandalay. MethodsThis study is a retrospective record review of the case series of COVID-19 patients admitted at

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Section: Strobe: Strengthening the Reporting Of Observational Studies...supporting

confidence: 85%

Clinical Profile of COVID-19 Patients Admitted at a Private Hospital During Three Surges in Mandalay, Myanmar

Kyu¹,

Ko²,

Lwin³

et al. 2023

Cureus

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Critically ill patients with COVID-19-associated acute kidney injury treated with kidney replacement therapy: Comparison between the first and second pandemic waves in São Paulo, Brazil

Samaan,

Freitas,

Viana

et al. 2023

PLoS ONE

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Introduction This study aimed to compare the characteristics and outcomes of critically ill patients with COVID-19-associated acute kidney injury (AKI) who were treated with kidney replacement therapy (KRT) in the first and second waves of the pandemic in the megalopolis of Sao Paulo, Brazil. Methods A multicenter retrospective study was conducted in 10 intensive care units (ICUs). Patients aged ≥18 years, and treated with KRT due to COVID-19-associated AKI were included. We compared demographic, laboratory and clinical data, KRT parameters and patient outcomes in the first and second COVID-19 waves. Results We assessed 656 patients (327 in the first wave and 329 in the second one). Second-wave patients were admitted later (7.1±5.0 vs. 5.6±3.9 days after the onset of symptoms, p<0.001), were younger (61.4±13.7 vs. 63.8±13.6 years, p = 0.023), had a lower frequency of diabetes (37.1% vs. 47.1%, p = 0.009) and obesity (29.5% vs. 40.0%, p = 0.007), had a greater need for vasopressors (93.3% vs. 84.6%, p<0.001) and mechanical ventilation (95.7% vs. 87.8%, p<0.001), and had higher lethality (84.8% vs. 72.7%, p<0.001) than first-wave patients. KRT quality markers were independently associated with a reduction in the OR for death in both pandemic waves. Conclusions In the Sao Paulo megalopolis, the lethality of critically ill patients with COVID-19-associated AKI treated with KRT was higher in the second wave of the pandemic, despite these patients being younger and having fewer comorbidities. Potential factors related to this poor outcome were difficulties in health care access, lack of intra-hospital resources, delay vaccination and virus variants.

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Retrospective study of comparison of clinical severity and outcome of hospitalised COVID-19 patients during the first and second waves of the pandemic in India

Cited by 2 publications

References 14 publications

Clinical Profile of COVID-19 Patients Admitted at a Private Hospital During Three Surges in Mandalay, Myanmar

Clinical Profile of COVID-19 Patients Admitted at a Private Hospital During Three Surges in Mandalay, Myanmar

Critically ill patients with COVID-19-associated acute kidney injury treated with kidney replacement therapy: Comparison between the first and second pandemic waves in São Paulo, Brazil

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