Retrospective Study of Childhood Ganglioneuroma

Bernardi, Bruno; Gambini, Claudio; Haupt, Riccardo; Granata, Claudio; Rizzo, A; Conte, Massimo; Tonini, Gian Paolo; Bianchi, Maurizio; Giuliano, Maria; Luksch, Roberto; Prete, Arcangelo; Viscardi, Elisabetta; Garaventa, Alberto; Sementa, Angela Rita; Bruzzi, Paolo; Angelini, Paola

doi:10.1200/jco.2006.08.8799

Cited by 130 publications

(155 citation statements)

References 19 publications

(19 reference statements)

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“…Five patients showed MIBG uptake at the end of treatment, but became negative during the follow-up course. De Bernardi et al (25) have reported in a retrospective study that the uptake of MIBG was recognized in 36.4% of ganglioneuromas. This is consistent with our results.…”

Section: A At Diagnosismentioning

confidence: 99%

Residual tumor in cases of intermediate-risk neuroblastoma did not influence the prognosis

Iehara

Yagyu

Tsuchiya

et al. 2016

Japanese Journal of Clinical Oncology

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Background: It remains unclear whether a residual tumor mass following therapy influences the prognosis of neuroblastoma. Methods: We retrospectively reviewed 20 patients with intermediate-risk tumors treated at our institution between 1993 and 2012 to elucidate whether additional treatment is required for residual tumors. Results: The patient ages at diagnosis ranged from 0 days to 7 years. The 5-year overall survival rate was 94.4%. Thirteen patients had Stage 3 disease and seven patients had Stage 4 disease. Nine patients showed intraspinal extension. Twelve patients had a residual tumor mass at the completion of therapy, and eight showed intraspinal extension. Five of these 12 patients showed metaiodobenzylguanidine (MIBG) uptake at the end of treatment, but the uptake disappeared during the follow-up period. Except for one patient who died due to treatment complications, the rest are all alive, and nine are alive with a residual mass. We examined the residual mass in four patients and found that these tissues had differentiated into a ganglioneuroma or changed to a necrotic tissue. For the three patients with neurological symptoms at the end of treatment, some slight neurological symptoms still remained during the follow-up. Five patients with an intraspinal mass eventually presented with new symptoms. Conclusions: The presence of a residual mass at the end of treatment did not influence the patients' prognosis. Therefore, an invasive radical surgical resection and additional treatment may not be necessary. Cases with a residual intraspinal mass also require a long-term follow-up to assess the neurological prognosis.

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Section: A At Diagnosismentioning

confidence: 99%

Residual tumor in cases of intermediate-risk neuroblastoma did not influence the prognosis

Iehara

Yagyu

Tsuchiya

et al. 2016

Japanese Journal of Clinical Oncology

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“…While early-stage tumors are treated effectively and may regress spontaneously, survival in patients with advanced-stage tumors is below 40% (2,3). Clinical heterogeneity and treatment morbidity (4,5) have driven the development of genetic and molecular screening approaches to identify children who may be spared intensive therapy (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Type III TGF-Î² receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

Knelson¹,

Gaviglio²,

Tewari³

et al. 2013

J. Clin. Invest.

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“…In human, ganglioneuromas tend to occur in children and adolescents and are commonly located in the thorax or abdomen [3,11]. In dogs, ganglioneuromas most commonly tend to occur in the central nervous system, followed by the alimentary tract, and the peripheral nervous system; in other animals such as cats, horses, and pigs, the alimentary tract is the most common site [1,5,6,12,15].…”

mentioning

confidence: 99%

Ganglioneuroma in the Small Intestine of a Juvenile Pig

Murakami

Sakai

Mizutani³

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. A mass was located in the small intestine of a slaughtered 6-month-old male Landrace-cross pig that had no clinical abnormalities. This egg-shaped well-circumscribed mass was situated in the submucosal and muscular tissue layers and protruded into the lumen. Histopathologically, the tumor comprised discrete or aggregated ganglion and schwannian cells in neuropil-like tissue. Some ganglion cells contained Nissl substance in their cytoplasm. The ganglion cells stained positive for neuron-specific enolase, class III -tubulin, neurofilament, and synaptophysin; the schwannian cells stained positive for vimentin, S-100 protein, and glial fibrillary acidic protein. The tumor was diagnosed as a ganglioneuroma in accordance with these findings. Here, we have reported detailed immunohistochemical findings in addition to the histopathological features of a swine ganglioneuroma.

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Retrospective Study of Childhood Ganglioneuroma

Cited by 130 publications

References 19 publications

Residual tumor in cases of intermediate-risk neuroblastoma did not influence the prognosis

Residual tumor in cases of intermediate-risk neuroblastoma did not influence the prognosis

Type III TGF-Î² receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

Ganglioneuroma in the Small Intestine of a Juvenile Pig

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