Retrospective Review of Clinical and Chest X-Ray Findings in Children Admitted to a Community Hospital for Respiratory Syncytial Virus Infection

Niles, Denver T.; Larsen, Brett; Arvind, Balaji; Delaney, Dana; Campos, Elizabeth; Bhattarai, Bikash; Shoshan, Dor; Connell, Mary J.; Ostovar, Gholamabbas Amin

doi:10.1177/0009922818795902

Cited by 6 publications

(21 citation statements)

References 19 publications

(30 reference statements)

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“…The other important point is, ACE protein had been detected in a variety of tissues, including the placenta, lungs and Oxygen support (n, %) 1 (10) 10 (50) .03 ÃÃ Noninvasive ventilation (n, %) 0 (0) 6 (30) .05 Invasive ventilation support (n, %) 0 (0) 4 (20) . Normal (n, %) 8 (80) 5 (25) .001 Ã Hiperinflation (n, %) 0 (0) 4 (20) .14 Bronchopneumonia (n, %) 1 (10) 8 (40) .12 Peribronchial thickening (n, %) 0 (0) 2 (10) .32 Atelectasis (n, %) 0 (0) 7 (35) .04 Ã Ã p < .05.…”

Section: Discussionmentioning

confidence: 99%

“…Atelectasis was defined as the presence of a transient pulmonary parenchymal opacity, which was defined as the loss of lung volume [8]. Pulmonary infiltration was defined as lobar, segmental, or subsegmental opacities with discrete or irregular margins [9,10]. Peribronchial thickening was defined as the presence of an increase in linear markings in the lungs, hyperinflation was described as hyperlucency of a portion of the lung, associated with hyperexpansion.…”

Section: Patient Managementmentioning

confidence: 99%

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Is respiratory syncytial virus infection more dangerous than COVID 19 in the neonatal period?

Özdemir

Soysal

Çalkavur

et al. 2020

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective: We aimed to compare the clinical features, laboratory findings and primary outcomes of the neonates with RSV and neonates with SARS-CoV-2 infections. Materials and methods: This nested case-control study included the neonates who were administered in the neonatal intensive care unit (NICU) of the University of Health Sciences, Dr Behc¸et Uz Children's Hospital during the period of 01 March-30 April 2020. Respiratory PCR samples and COVID-19 samples were taken simultaneously. Only RSV positive and COVID-19 positive infants were compared. Demographic, epidemiological and clinical data were obtained from hospital electronic information system medical records. The chest radiographs at the admission were evaluated by using standard definitions for normal chest Xray, atelectasis, bronchopenumonia, peribronchial thickening and hyperinflation in various lung volumes. Results: A total of 30 infants were enrolled in the study and RSV was identified in 20/30 infants (66%). No significant differences were observed between the two groups in terms of general characteristics. Comparing to the infants with Covid-19 infections, infants with RSV infections had significantly higher rates of having oxygen support (p ¼ .03). Total NICU duration time was 6.7 ± 1.6 days in COVID positive group and 11.1 ± 5.1 days in the RSV group (p ¼ .01). Infants with COVID-19 had more normal chest X-rays. Infants with RSV-positive had a significantly higher proportion of atelectasis than those with COVID-19 infants (p ¼ .04). Discussion: This is the first study that compares RSV infection and COVID-19 infection. RSV infection can be more serious in the neonatal period. In cases with suspected COVID-19 infection, it should be kept in mind if atelectasis is seen on chest radiography. Respiratory failure may be more serious in RSV positive infants and RSV infection may be more dangerous for the neonatal period.

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Section: Discussionmentioning

confidence: 99%

Section: Patient Managementmentioning

confidence: 99%

Is respiratory syncytial virus infection more dangerous than COVID 19 in the neonatal period?

Özdemir

Soysal

Çalkavur

et al. 2020

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

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“…Chest radiographic findings were classified as “normal,” “infiltration,” “air bronchogram,” and “reticulogranular view.” Infiltration on chest radiograph was defined as lobar, segmental, or subsegmental opacities. 5 Air bronchogram was defined as the bronchi containing air in the periphery of the hilum, becoming visible as a result of atelectasis of the lung tissue or displacement of air in the alveoli with waterproof and contrasting formations. Reticulogranular view was ground glass appearance on chest radiograph defined as increased opacity due to large diffuse atelectasis.…”

Section: Methodsmentioning

confidence: 99%

“…Chest radiographic findings were classified as normal, infiltration, air bronchogram, and reticulogranular view. 5 Babies' laboratory data were compared. In addition, the seasonal variability of lower respiratory tract virus in patients was analyzed.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Newborns with Non-COVID-19 Pneumonia Hospitalized in the Neonatal Intensive Care Unit during the COVID-19 Pandemic, Turkey, Izmir 2020–2021

Soysal

Özdemir

Gönüllü

et al. 2022

J Pediatr Infect Dis

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Objective In this study, we aimed to compare the clinical, laboratory, and radiological findings of noncoronavirus disease 2019 (COVID-19) viral agents in newborn infants hospitalized for lower respiratory tract infection during the COVID-19 pandemic. Methods This prospective cross-sectional study conducted between 11 March 2020 and 31 July 2021 included neonates with lower respiratory tract infections admitted to the neonatal intensive care unit of the Dr. Behcet Uz Children's Hospital. Nasopharyngeal swab samples were taken from all hospitalized patients for multiplex respiratory polymerase chain reaction (PCR) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR. The detection of respiratory viral pathogens was performed by multiplex real-time PCR assay (Bosphore Respiratory Pathogens Panel Kit V4, Anatolia Geneworks, Turkey). Infants with SARS-CoV-2 PCR positivity were excluded from the study. Patients' data were obtained from the electronic medical registry system. The non-COVID-19 viruses of the cases were analyzed according to seasonal variation (in/off-season). The pulmonary findings of the cases were classified as normal, infiltration, air bronchogram, and reticulogranular appearance at the time of admission. Results A total of 80 infants were included during the study period. A multiplex PCR test was performed to identify viral agents affecting the lower respiratory tract of infants; it was determined that 31% (25 out of 80) were respiratory syncytial virus (RSV), 41% (33 out of 80) were rhinovirus (Rhino), and the remaining portion (28%, 22 out of 80) were other viral agents (enterovirus, bocavirus, adenovirus, influenza, and parainfluenza). Compared with Rhino and other viral agents, RSV was detected most frequently in seasonal hospitalizations (p < 0.05). When chest radiography and laboratory findings were evaluated, the rate of “infiltration” /“lymphopenia” was significantly associated with infants with RSV lower respiratory tract infections (p < 0.05). Conclusion During the pandemic period, RSV affected the prognosis in intensive care unit admissions due to lower respiratory tract infection in newborns.

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“…In children, chest x-ray may be normal or abnormal with features of central airspace opacification and peribronchial thickening [52,53]. In adults and elderly patients, chest x-ray generally does not distinguish RSV pneumonia from bacterial infection and most commonly demonstrate bilateral alveolar opacities but may also show interstitial changes [54].…”

Section: Respiratory Syncytial Virusmentioning

confidence: 99%

Radiological, epidemiological and clinical patterns of pulmonary viral infections

Stefanidis

Konstantelou

Yusuf

et al. 2021

European Journal of Radiology

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Respiratory viruses are the most common causes of acute respiratory infections. However, identification of the underlying viral pathogen may not always be easy. Clinical presentations of respiratory viral infections usually overlap and may mimic those of diseases caused by bacteria. However, certain imaging morphologic patterns may suggest a particular viral pathogen as the cause of the infection. Although definitive diagnosis cannot be made on the basis of clinical or imaging features alone, the use of a combination of clinical and radiographic findings can substantially improve the accuracy of diagnosis. The purpose of this review is to present the clinical, epidemiological and radiological patterns of lower respiratory tract viral pathogens providing a comprehensive approach for their diagnosis and identification in hospitals and community outbreaks.

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Retrospective Review of Clinical and Chest X-Ray Findings in Children Admitted to a Community Hospital for Respiratory Syncytial Virus Infection

Abstract: Higher incidence of hypoxia or airspace opacification on chest X-ray may be predictors of poorer outcomes for patients with RSV infection.

Cited by 6 publications

References 19 publications

Is respiratory syncytial virus infection more dangerous than COVID 19 in the neonatal period?

Is respiratory syncytial virus infection more dangerous than COVID 19 in the neonatal period?

Evaluation of Newborns with Non-COVID-19 Pneumonia Hospitalized in the Neonatal Intensive Care Unit during the COVID-19 Pandemic, Turkey, Izmir 2020–2021

Radiological, epidemiological and clinical patterns of pulmonary viral infections

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