Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990

Abstract

The first imported case of severe haemorrhagic fever in Sweden was reported in 1990. Despite extensive diagnostic study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of plasma and urine samples collected during between 7 to 36 days from onset of symptoms, we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient most likely suffered from haemorrhagic symptoms due to a severe dengue infection.