Retrospective Long-Term Results and Prognostic Factors of Postoperative Treatment for UICC Stages II and III Rectal Cancer

Genovesi, Domenico; Cèfaro, Giampiero Ausili; Vinciguerra, A.; Augurio, Antonietta; D’Alessandro, Marco; Borzillo, Valentina; Marchese, Rita; Nicola, Marta Di

doi:10.1177/030089160909500606

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…Data from Genovesi et all confirmed these evaluations in the multivariate analysis, with a negative influence of extraperitoneal tumor location on DFS and CSS. 29 In this present study the carsinomas presenting at the lower rectum also had 40% 5 years survival which is comparable to the other studies as well. Pathological studies of the Circumferential Resection magrin (CRM) at the level of the anorectal junction and anal canal sphincter show higher rates of CRM involvement due to dissection along the thinning mesorectum on to the anal sphincter.…”

Section: -14supporting

confidence: 91%

Retrospective Long-term Results and Prognostic Factors of Treatment for Colorectal Cancer

Baltalarli¹

2013

UHOD

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To evaluate retrospectively 5-10 year overall survival rate in patients with colorectal cancer treated with or without adjuvant therapy for early stage and analyze the impact of some prognostic factors on clinical outcome we retrospectively reviewed 56 patients treated with only surgery, postoperative or preoperative 5-fluorouracil-based chemotherapy and radiotherapy. The following prognostic factors were considered at univariate analyses: age, sex, tumor location, pathological, tumoural and nodal stage, surgical procedure, pathological specimen margins and adjuvant treatment if applied. The 5 and 10 year actuarial rates for overall survival (OS) were 66 % and relapse free survival (RFS) rates were 83% and 58% respectively for all patients. Five years survival was 100%, 73% and 44% respectively for stages I, II and III (p< 0.01). Five years survival for N0, NI and NII disease were 81.3%, 75% and 0% respectively (p< 0.01). Better prognosis was observed for colon cancer compared to rectal and rectosigmoid tumors: 5 years survival rates 90%, 70% and 40% respectively (p< 0.01). Univariate analysis showed that nodal disease, location of tumor in a subsite of colon, pathological stage and surgical procedure had an impact on survival. Our retrospective study showed a good 5-10 year overall survival. Factors as individual pN2, tumor location and advanced pathological stage negatively influenced survival rates. In our opinion to achive better results especially in N2 cancer and rectal and rectosigmoid tumors, especially use of appropriate chemoradiation protocols and new high art radiation technology must be considered in clinical studies in advance. Keywords: Colorectal cancer, Prognostic factors, Radiotherapy ÖZET Kolorektal Kanser Tedavisinin Retrospektif Uzun Dönem Sonuçlar› ve Prognostik FaktörleriKolorektal kanserli ve postoperatif olarak adjuvan veya neoadjuvan tedavi uygulanm›fl veya erken klinik evrede olmas› nedeniyle cerrahi operasyon d›fl›nda ek tedavi uygulanmam›fl olan olgularda 5 ve 10 y›ll›k sa¤kal›m verilerini incelemek ve olas› prognostik faktör-leri belirlemek amac›yla çal›flma retrospektif analiz yöntemiyle planlanm›flt›r. Bu çal›flmada Pamukkale Üniversitesi T›p Fakültesi Radyasyon Onkolojisi Bölümüne tedavi ve izlem için baflvuran ve periyodik kontrollere ça¤›r›lan 56 lokal yerleflimli kolorektal kanserli olgu dosya verileri incelenerek retrospektif yöntemle de¤erlendirilmifltir. Yafl, cinsiyet, tümör evresi, nodal evre, patolojik evre özel-likleri, tümör yerleflimi, cerrahi yöntem, s›n›r tutulumu ve radyoterapi veya kemoterapi adjuvan uygulamalar› gibi de¤iflkenler yönün-den sa¤kal›mlar karfl›laflt›r›lm›fl ve aradaki farklar istatistiksel yönden de¤erlendirilmifltir. Befl ve 10 y›ll›k genel sa¤kal›m oranlar› %66, yinelemesiz sa¤kal›m oranlar› ise s›ras›yla 83% ve 58%dir. Evre I, II ve III için s›ras›yla sa¤kal›m %100, %73 ve %44 olup, N0, N1 ve N2 için s›ras›yla %81.3, %75 ve %0'd›r. Kolon kanseri di¤er rektal ve rektosigmoid yerleflimli tümörlere göre daha iyi sa¤kal›m gös-termekte olup s›...

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Section: -14supporting

confidence: 91%

Retrospective Long-term Results and Prognostic Factors of Treatment for Colorectal Cancer

Baltalarli¹

2013

UHOD

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“…Univariate analysis showed that in this study the well known prognostic factors, such as TNM stage, performance status, CEA serum level, resection margins, perineural, vascular and lymphatic invasion, node capsular effraction and recurrences [ 13 – 17 ] have statistically significantly influenced overall survival ( Table IV ).…”

Section: Discussionmentioning

confidence: 55%

The importance of a multidisciplinary team in rectal cancer management

Bochis

Fekete

Vlad

et al. 2017

Medicine and Pharmacy Reports

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IntroductionThe aim of this study was to evaluate the impact of the interval between surgery and adjuvant treatments regarding the overall survival and recurrence-free survival in patients from a developing country. For stages II and III rectal cancer, international guidelines recommend neoadjuvant chemoradiotherapy (CRT) regardless of the tumor location. In the developing countries there is a shortage of radiotherapy centers, specialists, which lead to long waiting lists for radiotherapy. These problems might lead to protocol deviations.MethodsWe conducted a retrospective study on 161 patients with rectal cancer treated with surgery, postoperative CRT and with or without chemotherapy for a total of 6 months, at The Oncology Institute Cluj-Napoca between 2006–2010. All patients had 5 years of follow-up.ResultsA total of 161 patients were enrolled in this study. The majority of patients were locally advanced stages (89.44%). The well known prognostic factors, such as TNM stage, performance status, CEA serum level, perineural, vascular and lymphatic invasion, and node capsular effraction had a statistically significant influence on overall survival. In 21.12% of patients the first adjuvant treatment was started in the first 4 weeks after surgery. Only 13.04% of patients started the concomitant CRT within the limit of 6 weeks after surgery. Concerning the time between surgery and CRT, we did not observe a statistically significantly difference in OS if the radiotherapy started after the first 6 weeks (p=0.701). The OS rate for locally advanced rectal cancer patients was 69.44%.ConclusionsIn rectal cancer, the importance of the first therapeutic act is crucial. Following international guidelines provides a survival advantage and a better quality of life. In case of adjuvant treatment, it is recommended to start this treatment as soon as the local infrastructure allows it.

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“…The frequency of follow-up is still debatable. With a moderate consensus, it was agree that the selection of patients for a tailored follow-up based on tumor stage and patient age is important [37][38][39] . Surveillance beyond the 5th year after the diagnosis is recommended in patients submitted to preoperative therapies.…”

Section: Evidencementioning

confidence: 99%

Rectal Cancer Multidisciplinary Treatment: Evidences, Consensus and Perspectives

Valvo

Mantello

Coco

et al. 2010

Tumori

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Retrospective Long-Term Results and Prognostic Factors of Postoperative Treatment for UICC Stages II and III Rectal Cancer

Cited by 4 publications

References 43 publications

Retrospective Long-term Results and Prognostic Factors of Treatment for Colorectal Cancer

Retrospective Long-term Results and Prognostic Factors of Treatment for Colorectal Cancer

The importance of a multidisciplinary team in rectal cancer management

Rectal Cancer Multidisciplinary Treatment: Evidences, Consensus and Perspectives

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