Retrospective gating for mouse cardiac MRI

Bishop, Jonathan; Feintuch, Akiva; Bock, Nicholas A.; Nieman, Brian J.; Dazai, Jun; Davidson, Lorinda; Henkelman, R. Mark

doi:10.1002/mrm.20794

Cited by 55 publications

(48 citation statements)

References 25 publications

(28 reference statements)

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“…As far as we observed, with a time resolution up to 1.92 s, the area of the anterior-posterior flow in the mantle cavity was almost constant, and we could not detect any cyclic motion of the mantle or the gill during the time period when the shells opened (supplementary material Movie 2). We also measured IntraGate MR images (retrospectively self-gated fast low angle shot sequences) (Bishop et al, 2006;Seo et al, 2014), but we could not detect any motion synchronized with the heart beat (data not shown).…”

Section: Research Articlementioning

confidence: 99%

Magnetic resonance imaging analysis of water flow in the mantle cavity of live Mytilus galloprovincialis

Seo

Ohishi

Maruyama

et al. 2014

Journal of Experimental Biology

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Water flow inside the shell of Mytilus galloprovincialis was measured by phase-contrast magnetic resonance imaging (MRI). In seawater without algal cells at 23°C, water approached the mussel from the posterior-ventral side, and entered through the inhalant aperture at a velocity of 40-20 mm s −1 . The flow rate in the lower mantle cavity decreased to 10-20 mm s −1 , the water flowed in the anterior-dorsal direction and approached the demibranches at a velocity of 5-10 mm s −1 . After passing through the lamellae to the upper mantle cavity, the water stretched the interlamellar cavity, turned to the posterior-dorsal direction and accumulated in the epibranchial cavity. The water flows came together at the ventral side of the posterior adductor muscle. The velocity increased more to than 50 mm s −1 in the exhalant siphon, and exhaled out in the posterior-dorsal direction. The anterior-posterior direction of the flow was imaged every 1.92 s by the inflow effect of T 1 -weighted MRI. The flow seemed to be constant, and no cyclic motion of the mantles or the gills was detected. Spontaneous closure of the shells caused a quick drop of the flow in the mantle cavity. In the opening process of the shells, water flow in the interlamellar cavities increased before the opening, followed by an increase of flows in the exhalant siphon and inhalant aperture with minimum delay, reaching a plateau within 1 min of the shells opening. This provides direct evidence that the lateral cilia drive water in the mussel M. galloprovincialis.

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Section: Research Articlementioning

confidence: 99%

Magnetic resonance imaging analysis of water flow in the mantle cavity of live Mytilus galloprovincialis

Seo

Ohishi

Maruyama

et al. 2014

Journal of Experimental Biology

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“…The heart motion was imaged by retrospectively self-gated fast low angle shot sequences (IntraGate) (Bohning et al, 1990;Bishop et al, 2006), using a transverse or longitudinal slice with a voxel resolution of 100×100 μm and a slice thickness of 1 mm with a combination of T R /T E /flip angle=30 ms/ 6 ms/22.5 deg. Data from 300 images were obtained sequentially for 20 min, and reconstructed into 10 images per cardiac cycle.…”

Section: Mrimentioning

confidence: 99%

Testing the constant-volume hypothesis by magnetic resonance imaging of the mussel heart in theMytilus galloprovincialis

Seo

Ohishi

Maruyama

et al. 2013

Journal of Experimental Biology

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The constant-volume (CV) hypothesis was tested using the Mytilus galloprovincialis heart under two conditions. The volume of the ventricle, auricles and pericardium, and the flow in the heart and adjacent vessels were measured by magnetic resonance imaging. In synthetic seawater at 23°C (immersed condition), the end-diastolic volume (EDV), end-systolic volume (ESV) and stroke volume (SV) were 50%, 21% and 29% of the heart volume, respectively, and the auricle volume (V A ) was maximized at end-systole. Assuming a constant volume of the heart, venous return to the auricles (I V ) was constant, and out-flow from the pericardium to the kidney (I PK ) was 2/3 of SV. During aerial exposure (emersed condition), EDV, ESV and SV decreased to 33%, 22% and 11%, respectively. V A was maximized at end-diastole and associated with the decrease of systolic I V to 1/2 of diastolic I V , while I PK remained at 80% of the immersed condition. Based on these results -in addition to two postulates of the CV hypothesis: (1) the total volume of the heart is always the same, and (2) ventricle contraction causes a decrease in pressure in the pericardium -we modified two postulates: (3) the low pericardial pressure maintains venous return from the anterior oblique vein to the auricle, and (4) the pressure difference between the auricle and the pericardium drives haemolymph filtration through the auricle walls. We also added a new postulate: (5) dilatation of the ventricle is associated with the haemolymph output to the kidney via the renopericardial canals.

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“…Cardiac imaging in mice has traditionally been implemented in MRI and CT using electrocardiogram (ECG) gated prospective and retrospective techniques [1], [2], [3], [4]. In retrospective imaging, image data and physiologic waveforms are continuously acquired and collated in post-processing to produce cine loops of the cardiac cycle with fine temporal resolution.…”

Section: Introductionmentioning

confidence: 99%

ECG-gated imaging of a mouse heart using a 40-MHz annular array

Ketterling

Aristizábal

Turnbull

2008

2008 IEEE Ultrasonics Symposium

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Prospective imaging with an annular-array scan system was implemented to image the mouse heart at high frame rates (> 200 frames/s, fps). M-mode data were acquired at a series of spatial locations using ECG gating. The pulse-repetition frequency of the M-mode data determined the frame rate of the final, reassembled B-mode images. The hearts of adult mice were prospectively imaged with a 40-MHz annular array. Annulararray data were acquired at an effective frame rate of 500 frames/s spanning 0.5 s. Data from the annular array were acquired for all transmit-to-receive pairs and synthetically focused in post-processing. The resulting images showed that multiple heart cycles could be clearly resolved using prospective imaging and that synthetic focusing improved the image resolution and SNR of the right ventricle, interventricular septum, posterior edge of the left ventricle (LV), and papillary muscles of the LV compared to fixed-focused imaging.

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Retrospective gating for mouse cardiac MRI

Cited by 55 publications

References 25 publications

Magnetic resonance imaging analysis of water flow in the mantle cavity of live Mytilus galloprovincialis

Magnetic resonance imaging analysis of water flow in the mantle cavity of live Mytilus galloprovincialis

Testing the constant-volume hypothesis by magnetic resonance imaging of the mussel heart in theMytilus galloprovincialis

ECG-gated imaging of a mouse heart using a 40-MHz annular array

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