Retrospective evaluation of the use of quick Sepsis‐related Organ Failure Assessment (qSOFA) as predictor of mortality and length of hospitalization in dogs with pyometra (2013‐2019): 52 cases

Donati, Pablo; Londoño, Leonel; Tunes, Marcela; Villalta, Cesar; Guillemi, Eliana Carolina

doi:10.1111/vec.13103

Cited by 4 publications

(2 citation statements)

References 23 publications

(26 reference statements)

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“…In a critically ill population of dogs, qSOFA was not predictive of mortality in contrast to plasma lactate concentration, but that population had few dogs with sepsis 100 . When used to assess dogs with surgical sepsis where the overall mortality rates were >30%, qSOFA was associated with duration of hospitalization and mortality 101,102 . In a study of 45 dogs with suspected or confirmed infection admitted to an ICU where the mortality rate was 42%, a composite score of mentation, heart rate, and venous carbon dioxide (Pv co 2 ) was predictive of outcome 103 .…”

Section: Sepsis‐3 (Society Of Critical Care Medicine European Society...mentioning

confidence: 99%

“…100 When used to assess dogs with surgical sepsis where the overall mortality rates were >30%, qSOFA was associated with duration of hospitalization and mortality. 101,102 In a study of 45 dogs with suspected or confirmed infection admitted to an ICU where the mortality rate was 42%, a composite score of mentation, heart rate, and venous carbon dioxide (PvCO 2 ) was predictive of outcome. 103 These results suggest that incorporating organ dysfunction into severity assessments has merit, recognizing that modifications to parameters or criteria to account for biological variation between species may be required.…”

Section: Organ System Scorementioning

confidence: 99%

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Defining sepsis in small animals

Cortellini,

DeClue,

Giunti

et al. 2024

J Vet Emergen Crit Care

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ObjectiveTo discuss the definitions of sepsis in human and veterinary medicine.DesignInternational, multicenter position statement on the need for consensus definitions of sepsis in veterinary medicine.SettingVeterinary private practice and university teaching hospitals.AnimalsDogs and cats.InterventionsNone.Measurements and Main ResultsSepsis is a life‐threatening condition associated with the body's response to an infection. In human medicine, sepsis has been defined by consensus on 3 occasions, most recently in 2016. In veterinary medicine, there is little uniformity in how sepsis is defined and no consensus on how to identify it clinically. Most publications rely on modified criteria derived from the 1991 and 2001 human consensus definitions. There is a divergence between the human and veterinary descriptions of sepsis and no consensus on how to diagnose the syndrome. This impedes research, hampers the translation of pathophysiology insights to the clinic, and limits our abilities to optimize patient care. It may be time to formally define sepsis in veterinary medicine to help the field move forward. In this narrative review, we present a synopsis of prior attempts to define sepsis in human and veterinary medicine, discuss developments in our understanding, and highlight some criticisms and shortcomings of existing schemes.ConclusionsThis review is intended to serve as the foundation of current efforts to establish a consensus definition for sepsis in small animals and ultimately generate evidence‐based criteria for its recognition in veterinary clinical practice.

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Section: Sepsis‐3 (Society Of Critical Care Medicine European Society...mentioning

confidence: 99%

Section: Organ System Scorementioning

confidence: 99%

Defining sepsis in small animals

Cortellini,

DeClue,

Giunti

et al. 2024

J Vet Emergen Crit Care

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Pyometra in Small Animals 3.0

Hagman

2023

Veterinary Clinics of North America: Small Animal Practice

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Evaluation of qSOFA and variation of hematochemical profile in cats naturally infected with feline panleukopenia virus

Gülersoy

Erol

et al. 2023

Open Veterinary Science

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Feline panleukopenia (FP) is a fatal viral disease that predisposes cats to sepsis and organ failure. Owing to a wide variety of clinical findings, hematochemical examinations are significant for the determination of early signs of disease-related complications. The aim of this study is to investigate the diagnostic efficacy of certain hematochemical parameters together with quick Sepsis-related Organ Failure Assessment (qSOFA) in cats with FP. A total of 10 healthy and 30 panleukopenic cats were included in this study. Physical examinations revealed that the body temperature was highest in septic panleukopenic cats (p < 0.009) and they had higher qSOFA scores (p = 0.000). Hemogram analysis revealed that leukocyte, lymphocyte, granulocyte, erythrocyte, and hemoglobin levels were lower in non-septic panleukopenic cats compared with the healthy ones (p < 0.030). Also, monocyte and mean corpuscular hemoglobin levels were lower in septic ones (p < 0.048). Serum biochemistry profiling revealed higher blood urea nitrogen, creatinine, alanine aminotransferase, lactate dehydrogenase, total bilirubin, and C-reactive protein levels in panleukopenic cats (p < 0.033). As a result, it was concluded that although the qSOFA is not sufficient to distinguish sepsis in cats, unlike dogs, in order to achieve a positive clinical outcome, when evaluated together with hematochemical variables, it may help in making early diagnosis of FP-related complications.

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Retrospective evaluation of the use of quick Sepsis‐related Organ Failure Assessment (qSOFA) as predictor of mortality and length of hospitalization in dogs with pyometra (2013‐2019): 52 cases

Abstract: Objective: To evaluate the prognostic utility of quick Sepsis-related Organ Failure Assessment (qSOFA) for prediction of in-hospital mortality and length of hospitalization in dogs with pyometra.

Cited by 4 publications

References 23 publications

Defining sepsis in small animals

Defining sepsis in small animals

Pyometra in Small Animals 3.0

Evaluation of qSOFA and variation of hematochemical profile in cats naturally infected with feline panleukopenia virus

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