Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010–2013)

Olan, Natasha V.; Prittie, Jennifer

doi:10.1111/vec.12306

Cited by 9 publications

(4 citation statements)

References 40 publications

(117 reference statements)

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“…The major findings of this study were that hypocaloric PPN at 40-50% of RER resulted in mitigation of weight loss and lower mortality and was associated with no septic or metabolic complications. The lack of metabolic or septic complications with PPN was in contrast to those reported in other similar studies [8,[17][18][19]. We did not find any laboratory value in the treatment group in which the value was within the reference interval prior to PN administration and abnormal after its implementation.…”

Section: Discussioncontrasting

confidence: 99%

“…Most of the recent studies on canine patients establish hyperglycemia as the most common metabolic complication associated with the administration of PN [8,[17][18][19]. Additionally, in human clinical studies, duration of total parenteral nutrition (TPN) therapy and high dextrose delivery were found to be important risk factors and independent predictors for developing hyperglycemia in TPN patients.…”

Section: Discussionmentioning

confidence: 99%

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The effect of short term peripheral parenteral nutrition on treatment outcomes and mortality in critically ill pediatric canine patients

et al. 2021

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Background Peripheral parenteral nutrition (PPN) is increasingly considered as an alternative to central parenteral nutrition (CPN) given the higher cost and more frequent clinical complications associated with the latter. However, the assessment of potential risks and benefits of PPN in critically ill pediatric canine patients has not been extensively performed. In this study, we aimed to explore the effect of short-term, hypocaloric PPN on weight loss, length of hospital stay, the incidence of complications, adverse effects, and mortality in critically ill pediatric canine patients. Results Between August 2015 and August 2018, a total of 59 critically ill pediatric canine patients aged from 1 to 6 months admitted at the Veterinary Sciences Research Institute of the Autonomous University of Baja California were included in this non-randomized clinical trial. Canine pediatric patients were initially allocated to 3 groups: 11 in group 1 receiving parenteral nutrition (PN) supplementation equivalent to 40% of the resting energy requirement (RER), 12 in group 2 receiving supplementation of 50% of the RER, and 36 in group 3 receiving no PN supplementation. After establishing that there was no significant difference between 40 and 50% of PN supplementation, these groups were not separated for downstream analysis. Similar lengths of hospital stays were noted among study subjects who received PN supplementation and those who did not (4.3 ± 1.5 vs. 5.0 ± 1.5, days, p = 0.097). No metabolic-, sepsis- or phlebitis-related complications were observed in any animal in the PPN supplemented group. Higher mortality (19.4% vs. 0%, p = 0.036), and a greater percentage of weight loss (9.24% vs. 0%, p < 0.001) were observed in patients who received no supplementation. Conclusion Even though short-term, hypocaloric PPN did not reduce the length of hospital stay, it was associated with lower mortality and resulted in mitigation of weight loss. In contrast to previous studies evaluating central and peripheral parenteral nutrition protocols, we observed a lower frequency of metabolic, septic, and phlebitis complications using a 40–50% parenteral nutrition treatment. The parenteral nutrition therapeutic intervention used in our study may reduce PN-related adverse effects and promote a favorable disease outcome in critically ill canine patients. Larger studies will be needed to confirm these observations.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of short term peripheral parenteral nutrition on treatment outcomes and mortality in critically ill pediatric canine patients

et al. 2021

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“…Additionally, there is a large volume of published studies describing the role of opioids in reducing or exacerbating gastrointestinal dysfunction and hindering the acceptance of oral or enteral feeding (Olan & Prittie 2015); therefore, early parenteral nutrition may be beneficial in these dogs.…”

Section: Discussionmentioning

confidence: 99%

Early parenteral nutrition in enterectomized dogs

et al. 2018

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The aim of this study was to explore the role of early central parenteral nutrition support with and without lipid emulsion in enterectomized dogs undergoing small bowel partial resection. Enterectomized dogs often cannot be fed properly via an oral or enteral route immediately post-surgery. After enterectomy, the animals received parenteral nutrition or crystalloid solution until they were able to voluntarily take in an oral diet. All dogs were recruited at the University of Sao Paulo veterinary teaching hospital. Eighteen dogs with intussusception, a foreign intestinal body, linear foreign intestinal body, or intussusception associated with a foreign intestinal body underwent enterectomy surgery and were randomly assigned to receive one of three treatments: crystalloid solution (CS group), parenteral nutrition with a mix of glucose and amino acids (GA group) or parenteral nutrition with a mix of glucose, amino acids and lipids (GAL group). A serum chemistry panel and complete blood count were collected prior to surgery and at the end of the study. Albumin increased in the GA and GAL group (p=0.042 and p=0.038 respectively) after hospitalization, but no significant differences were identified among the groups. Body weight decreased by 4.9% (p=0.042) in the CS group, but there were no significant changes in the GAL and GA groups. There was a significant decrease in the recovery scores in the GA and GAL groups during hospitalization (p=0.039 in both groups). Early parenteral nutrition was beneficial for patient recovery in post-surgical small bowel partial resection, indicating better quality, and no major complications or side effects were observed during the hospitalization period in the studied dogs.

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“…However, as intervention measures become more intensive, and in some cases, more invasive, the potential for high‐impact iatrogenic error also increases. Recent studies have documented the complications associated with fluid overload, 2 frequent phlebotomy, 3 parenteral nutrition, 4 feeding tube displacement, 5 and multidrug‐resistant nosocomial infections 6,7 in the veterinary ICU setting. These studies all suggest that in the ICU environment, patient safety is contingent on the constant vigilance of the staff providing care.…”

Section: Introductionmentioning

confidence: 99%

A multicenter observational study investigating care errors, staffing levels, and workload in small animal intensive care units

Hayes

Bersenas

Mathews

et al. 2020

J Vet Emergen Crit Care

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Objective To investigate associations among care errors, staffing, and workload in small animal ICUs. Design Multicenter observational cohort study conducted between January 2017 and September 2018. Setting Three small animal teaching hospital ICUs. Animals None. Interventions None. Measurements and main results Data on patient numbers, illness severity (assesed via the acute patient physiologic and laboratory evaluation [APPLE] score), care burden, staffing levels, technician experience/education level, and care errors were collected at each study site. Care errors were categorized as major (unanticipated arrest or death; patient endangerment through IV line, arterial catheter, chest tube or other invasive device mismanagement, or errors in drug calculation/administration) or minor. Median patient:technician ratio was 4.3 (range: 1–18). Median patient illness severity was 15.1 (4.7–27.1) APPLE score units. A total of 221 major and 3,317 minor errors were observed over the study period. The odds of a major error increased by an average of 11% (odds ratio [OR] = 1.11; 95% confidence interval [CI], 1.02–1.20; P = 0.012) for each 1 patient increase in the patient:technician ratio after averaging by ICU location. The major error incident rate ratio was 2.53 (95% CI, 1.84–3.54; P < 0.001) for patient:technician ratios of >4.0 compared with ≤4.0. The odds of a major error increased by 0.5% per total unit APPLE score increase (OR = 1.005; 95% CI, 1.002–1.007; P < 0.001). The major error incident rate ratio was 1.71 (95% CI, 1.30–2.25; P < 0.001) for APPLEfast:technician ratios of >73 compared with ≤73. The odds of a major error decreased by 2% (OR = 0.98; 95% CI, 0.97–0.99; P = 0.01) for each year increase in total technician years of ICU work experience. Conclusions Substantial reductions in major care errors may be achieved by maintaining ICU patient:technician ratios at ≤4. Technician experience and total unit burden of patient illness severity are also associated with error incidence, and should be taken into consideration when scheduling staff.

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Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010–2013)

Abstract: ProcalAmine appears to be relatively safe and a viable option for parenteral nutrition in ill and injured dogs. Due to the potential for electrolyte derangements and other metabolic complications, daily monitoring of these parameters is advisable.

Cited by 9 publications

References 40 publications

The effect of short term peripheral parenteral nutrition on treatment outcomes and mortality in critically ill pediatric canine patients

The effect of short term peripheral parenteral nutrition on treatment outcomes and mortality in critically ill pediatric canine patients

Early parenteral nutrition in enterectomized dogs

A multicenter observational study investigating care errors, staffing levels, and workload in small animal intensive care units

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