Retrospective Evaluation of Factors Related to the Outcomes of Regenerative Therapy for Implants Affected by Peri-implantitis

Froum, Stuart J.; Rosen, Paul S.; Wang, Wendy Cw; Froum, Scott H; Vinayak, Shalin

doi:10.11607/prd.3489

Cited by 8 publications

(7 citation statements)

References 11 publications

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“…All corresponding researchers were contacted to request clarification or further information. Four records were excluded as double‐data, with the most relevant data retained for analysis (Froum, Rosen, Wang, Froum & Vinayak, ; Romeo, Lops, Chiapasco, Ghisolfi & Vogel, ; Roos‐Jansåker, Lindahl, Persson & Renvert, ; Schwarz, Hegewald, John, Sahm & Becker, ). Eighteen studies were included in qualitative assessments, with 13 in quantitative assessments.…”

Section: Resultsmentioning

confidence: 99%

Clinical outcomes of peri‐implantitis treatment and supportive care: A systematic review

Roccuzzo

Layton

Roccuzzo³

et al. 2018

Clinical Oral Implants Res

137

103

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Objectives: To report the clinical outcomes for patients with implants treated for peri-implantitis who subsequently received supportive care (supportive peri-implant/ periodontal therapy) for at least 3 years. Material and methods:A systematic search of multiple electronic databases, grey literature and hand searching, without language restriction, to identify studies including ≥10 patients was constructed. Data and risk of bias were explored qualitatively. Estimated cumulative survival at the implant-and patient-level was pooled with random-effects meta-analysis and explored for publication bias (funnel plot) at different time intervals. Results:The search identified 5,761 studies. Of 83 records selected during screening, 65 were excluded through independent review (kappa = 0.94), with 18 retained for qualitative and 13 of those for quantitative assessments. On average, studies included 26 patients (median, IQR 21-32), with 36 implants (median, IQR 26-45). Study designs (case definitions of peri-implantitis, peri-implantitis treatment, supportive care) and population characteristics (patient, implant and prosthesis characteristics) varied markedly. Data extraction was affected by reduced reporting quality, but over 75% of studies had low risk of bias. Implant survival was 81.73%-100% at 3 years (seven studies), 74.09%-100% at 4 years (three studies), 76.03%-100% at 5 years (four studies) and 69.63%-98.72% at 7 years (two studies). Success and recurrence definitions were reported in five and two studies respectively, were heterogeneous, and those outcomes were unable to be explored quantitatively.Conclusion: Therapy of peri-implantitis followed by regular supportive care resulted in high patient-and implant-level survival in the medium to long term. Favourable results were reported, with clinical improvements and stable peri-implant bone levels in the majority of patients. K E Y W O R D Sdental implants, dental restoration failure, long-term care, meta-analysis, peri-implantitis, periodontal maintenance, supportive periodontal therapy, surgical treatment, survival, systematic reviewThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Section: Resultsmentioning

confidence: 99%

Clinical outcomes of peri‐implantitis treatment and supportive care: A systematic review

Roccuzzo

Layton

Roccuzzo³

et al. 2018

Clinical Oral Implants Res

137

103

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“…Several studies have investigated the influence of the type of antibiotic in patients who self-reported allergy to penicillin in various implant procedures [27][28][29][30][31]. In this regard, Khoury et al [27] (2018) prescribed clindamycin 600 mg 1 h preoperatively followed by 300 mg/8 h/7 days postoperatively in patients with SRPA, while in the nonallergic group they prescribed amoxicillin 2 g preoperatively for antibiotic prophylaxis Antibiotics 2021, 10, x FOR PEER REVIEW [15], it was determined that four of the papers included had a high-quality assess 10 domains) [16,17,19,20] and one of them had a low-quality assessment (0-5 d [18].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have investigated the influence of the type of antibiotic in patients who self-reported allergy to penicillin in various implant procedures [27][28][29][30][31]. In this regard, Khoury et al [27] (2018) prescribed clindamycin 600 mg 1 h preoperatively Yes; tibiotics 2021, 10, x FOR PEER REVIEW 7 of 13 [15], it was determined that four of the papers included had a high-quality assessment (5-10 domains) [16,17,19,20] and one of them had a low-quality assessment (0-5 domains) [18].…”

Section: Discussionmentioning

confidence: 99%

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Is Penicillin Allergy a Risk Factor for Early Dental Implant Failure? A Systematic Review

et al. 2021

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The prescription of preventive antibiotics in dental implant treatments reduces the incidence of early failures. This study has focused mainly on the influence of amoxicillin, which is contraindicated in penicillin-allergic patients. The present systematic review aimed to determine whether penicillin-allergic patients have a higher risk of implant failure compared to non-allergic patients. An electronic search was performed on Medline and Web of Science using the following MeSH terms: (penicillin allergy OR clindamycin OR erythromycin OR azithromycin OR metronidazole) AND (dental implant OR dental implant failure OR dental implant complications). The criteria employed were those described in the PRISMA® Declaration. Only five articles were included that analyzed the failure rates of implants placed in penicillin-allergic patients who were prescribed clindamycin compared to non-allergic patients who were prescribed amoxicillin. With the limitations of this study, it is not possible to state that penicillin allergy per se constitutes a risk factor for early dental implant failure as most of the studies included self-reported allergic patients. Clindamycin has been associated with a significantly elevated risk of failure and an up to six times increased risk of infection. Immediate implants also have a 5.7 to 10 times higher risk of failure.

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“…Saaby et al (2016) reported that 44% of patients referred for treatment of periimplantitis had some systemic disease and that the incidence of CVD in the group was 26%. Froum et al (2018) reported that 48 of 100 patients treated for peri-implantitis had a history of hypertension. The authors concluded that there has been little or no mention of hypertension (controlled) as a risk factor for peri-implantitis.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Peri-implantitis: risk factors and outcome of reconstructive therapy

Ahmad¹

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This thesis is focused on (I) the outcome of reconstructive treatment of peri-implant defects and (II) risk factors for the development of peri-implantitis. Background An increasing number of individuals have dental implant-supported reconstructions. The long-time survival rate of dental implants is good, but complications do occur. Accumulation of bacteria on oral implants and the development of a pathogenic biofilm at the mucosal margin will result in inflammatory responses diagnosed as peri-implant mucositis(PiM). Furthermore, PiM may progress to peri-implantitis (Pi) involving the implant-supporting bone and potentially result in a severe inflammatory process resulting in alveolar bone destruction and consequently implantloss. Currently, Pi is a common clinical complication following implant therapy.The prevalence of peri-implantitis has been reported to be around 20 %. Susceptibility to infections and a history of periodontitis are considered as important risk indicators for peri-implantitis. It seems logical that a past history of periodontitis is linked to an increased risk of peri-implantitis. It is possible that other patient-associated factors such as a smoking habit, and presence of general diseases may also be linked to a higher risk for developing peri-implantitis.Treatment of peri-implantitis is difficult. Non-surgical treatment modalities may not be sufficient to resolve the inflammatory process to obtain healthy conditions.Surgical treatment of peri-implantitis has commonly been employed in clinical practice to obtain access to the implant surface thereby increasing the possibility to effectively decontaminate the implant surfaces.The effectiveness and long-term outcomes of reconstructive surgical treatments of peri-implantitis has been debated. The scientific evidence suggests that regular supportive care is an essential component in order to maintain and secure long-term results following treatment of peri-implantitis. Aims 1. To assess the short-term efficacy of reconstructive surgical treatmentof peri-implantitis (Study I). 2. To analyse risk factors related to the occurrence of peri-implantitis(Study II). 3. To assess the importance of defect configuration on the healing response after reconstructive surgical therapy of peri-implantitis (Study III). 4. To assess the long-term efficacy of reconstructive surgical treatmentof peri-implantitis (Study IV). MethodsFour studies were designed to fulfil the aims: - A single-blinded prospective randomised controlled longitudinal human clinical trial evaluating the clinical and radiographic results of reconstructive surgical treatment of peri-implantitis defects usingeither AB or BDX. - A retrospective analysis of individuals with either peri-implantitis, or presenting with either peri-implant health, or peri-implant mucositis assessing the likelihood that peri-implantitis was associated with a history of systemic disease, a history of periodontitis, and smoking. - A prospective study evaluating if the alveolar bone defect configuration at dental implants diagnosed with peri-implantitisis related to clinical parameters at the time of surgical intervention and if the short- and long-term outcome of surgical intervention of peri-implantitis is dependent on defect configuration at the time of treatment. - A prospective 5-year follow-up of patients treated either with AB or BDX. Results - The success for both surgical reconstructive procedures was limited. Nevertheless, bovine xenograft provided evidence of more radiographic bone fill than AB. Improvements in PD, BOP, and SUP were observed for both treatment modalities -In relation to a diagnosis of peri-implantitis, a high likelihood of comorbidity was expressed in the presence of a history of periodontitis and a medical history of cardiovascular disease - The buccal-lingual width of the alveolar bone crest was explanatory to defect configuration - 4-wall defects and deeper defects demonstrated more radiographic evidence of defect fill - Reconstructive surgical treatment of peri-implant defects may result in successful clinical outcomes, that can be maintained over at least five years - The use of BDX is more predictable than use of harvested bone from the patient (AB) Conclusions The study results suggest that a bovine xenograft provides better radiographic evidence of defect fill than the use of autogenous bone harvested from cortical autologous bone grafts.Treatment with bone grafts to obtain radiographic evidence of defect fill is more predictable at 3- and 4-wall defects than at peri-implantitis bone defects with fewer bone walls.In relation to a diagnosis of peri-implantitis, a high likelihood of comorbidity was found for a history of periodontitis and a history of cardiovascular disease.

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Retrospective Evaluation of Factors Related to the Outcomes of Regenerative Therapy for Implants Affected by Peri-implantitis

Cited by 8 publications

References 11 publications

Clinical outcomes of peri‐implantitis treatment and supportive care: A systematic review

Clinical outcomes of peri‐implantitis treatment and supportive care: A systematic review

Is Penicillin Allergy a Risk Factor for Early Dental Implant Failure? A Systematic Review

Peri-implantitis: risk factors and outcome of reconstructive therapy

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