Retrospective evaluation of clinical and pathological features, as well as diagnostic and treatment protocols of primary vaginal malignancy

Kulhan, Gozde; Külhan, Mehmet; Naykı, Ümit; Naykı, Cenk; Ulug, Pasa; Akkaya, Emrah; Aldemir, Onur Süleyman; Yıldırım, Yusuf; Sipahi, Mehmet

doi:10.5603/gp.2016.0041

Cited by 1 publication

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“…In our series, all 7 patients with vaginal RMS had the botryoid variant and all were younger than 3 years of age. If cervical and vaginal involvement is detected together, it is assumed a primary cervical malignancy [ 26 ]. Accordingly, we excluded the patient with embryonal RMS that had both cervical and vaginal involvement at the age of 144 months.…”

Section: Discussionmentioning

confidence: 99%

Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma

et al. 2017

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The aim of this study was to evaluate the conservative management and prognosis of primary vaginal endodermal sinus tumor and rhabdomyosarcoma in children. Medical records of children with vaginal endodermal sinus tumor and rhabdomyosarcoma between 1996 and 2015 were reviewed. A total of 24 patients (median age, 12 months; range, 7–44 months) were included in this study, comprising 17 patients with endodermal sinus tumor and 7 patients with rhabdomyosarcoma. Among the 17 patients with endodermal sinus tumor, 15 were initially treated at our hospital with chemotherapy alone, and 2 were initially treated in other hospitals with conservative surgery and chemotherapy. All 7 patients with botryoid rhabdomyosarcoma received chemotherapy without well-defined protocols. At a median follow-up of 51 months (range, 4–237 months), 3 patients (12.5%; 1 with endodermal sinus tumor and 2 with rhabdomyosarcoma) developed recurrence. At the last follow-up, 22 patients (91.7%) were alive without evidence of disease, 1 patient with botryoid rhabdomyosarcoma died of disease progression, and 1 patient with endodermal sinus tumor died of respiratory and circulatory failure. To allow preservation of sexual and reproductive function, conservative therapeutic strategies should be considered for children with vaginal endodermal sinus tumor and botryoid rhabdomyosarcoma.

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Section: Discussionmentioning

confidence: 99%