Retrospective Evaluation of Anemia and Transfusion in Traumatic Brain Injury

Carlson, Andrew P.; Schermer, Carol R.; Lu, Stephen W.

doi:10.1097/01.ta.0000231768.44727.a2

Cited by 112 publications

(83 citation statements)

References 21 publications

(15 reference statements)

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“…During anemia, CBF increases as a result of improved rheology of the blood flow in the cerebral vessels and as a compensatory response to decreased oxygen delivery [57]. While some data suggests that hematocrit < 30% is associated with worse discharge Glasgow Outcome Scale scores in adults with severe TBI [58], neither the optimal duration for maintaining a specific hemoglobin level, nor the relationship between target transfusion and neurological outcome are fully known [59]. A recent study of critically ill children demonstrated that maintaining hemoglobin of 7 g/dl rather than 9.5 g/dl can reduce requirements for blood transfusion, but none of these subjects had TBI [60].…”

Section: Control Of the Cerebral Circulationmentioning

confidence: 99%

Cerebral Blood Flow and Autoregulation After Pediatric Traumatic Brain Injury

Udomphorn

Armstead

Vavilala

2008

Pediatric Neurology

132

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Traumatic brain injury is a global health concern and is the leading cause of traumatic morbidity and mortality in children. Despite a lower overall mortality than in adult traumatic brain injury, the cost to society from the sequelae of pediatric traumatic brain injury is very high. Predictors of poor outcome after traumatic brain injury include altered systemic and cerebral physiology, including altered cerebral hemodynamics. Cerebral autoregulation is often impaired following traumatic brain injury and may adversely impact poor outcome. Although altered cerebrovascular hemodynamics early after traumatic brain injury may contribute to disability in children, there is a paucity of information regarding changes in cerebral blood flow and cerebral autoregulation after pediatric traumatic brain injury. In this article, we discuss normal pediatric cerebral physiology and cerebrovascular pathophysiology following pediatric traumatic brain injury.

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Section: Control Of the Cerebral Circulationmentioning

confidence: 99%

Cerebral Blood Flow and Autoregulation After Pediatric Traumatic Brain Injury

Udomphorn

Armstead

Vavilala

2008

Pediatric Neurology

132

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“…При более низком уровне транспорт кислорода уменьшается без заметного изменения вязкости крови, а при уровне более 0,30 -вязкость повышается непропорцио-нально транспорту кислорода. Впрочем, в последних исследованиях отмечено, что низкий уровень гема-токрита также допустим, в настоящее время прием-лемой считают его величину 0,21-0,30 [77][78][79].…”

Section: лечебные мерыunclassified

Monitoring and treatment of severe traumatic brain injury

Кардаш¹,

Cherniy²,

Gorodnik³

et al. 2014

Ukr Neurosurg J

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“…Como en otros subgrupos de pacientes de UCI, parece que podrían ser seguras tasas menores 54,55 , aunque todavía está pendiente determinar el nivel óptimo y en qué fase de la evolución.…”

Section: Manejo De La Presión De Perfusión Cerebralunclassified

Actualizaciones en el manejo del traumatismo craneoencefálico grave

2009

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El traumatismo craneoencefálico (TCE) es una importante causa de morbimortalidad en cualquier lugar del mundo; afecta más a varones jóvenes y genera un problema de salud pública. Desafortunadamente, los avances en los conocimientos fisiopatológicos no han ido seguidos de similar desarrollo en las opciones terapéuticas, y no se dispone en la actualidad de fármacos neuroprotectores contrastados.En este artículo revisamos la epidemiología, la fisiopatología y las medidas terapéuticas utilizadas en el manejo del paciente con TCE grave. Se analizan tanto las medidas generales como las dirigidas al control de la hipertensión intracraneal, el papel de la cirugía y algunas opciones terapéu-ticas más innovadoras actualmente en fase de valoración en estos pacientes. UPDATES OF SEVERE TRAUMATIC BRAIN INJURY MANAGEMENT Traumatic brain injury (TBI)is an important reason of morbidity-mortality all over the world, affecting young males more and generating Public Health problem. Unfortunately, the advances in the pathophysiology knowledge have not followed a similar development in therapeutic options, there currently not being any contrasted neuroprotectants.In this article, we have reviewed the epidemiology, pathophysiology and therapeutic measures used in the management of patient with severe TBI. The general measures as well as those aimed at controlling intracranial hypertension, the role of the surgery and some more innovative therapeutic options currently under evaluation in these patients are analyzed.

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Retrospective Evaluation of Anemia and Transfusion in Traumatic Brain Injury

Abstract: Patients with severe TBI should not have a different transfusion threshold than other critical care patients. Prospective studies are needed to evaluate the effects of anemia in TBI.

Cited by 112 publications

References 21 publications

Cerebral Blood Flow and Autoregulation After Pediatric Traumatic Brain Injury

Cerebral Blood Flow and Autoregulation After Pediatric Traumatic Brain Injury

Monitoring and treatment of severe traumatic brain injury

Actualizaciones en el manejo del traumatismo craneoencefálico grave

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