Retrospective Evaluation of Adverse??Drug Reactions Induced??by??Nonsteroidal Anti-Inflammatory Drugs

Abstract

NSAID therapy represents a common cause of ADRs in hospitalised patients. Their use should be carefully considered, especially in the presence of polydrug therapy.

Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes

“…Bejer and de Blaey [44] reported that the proportion of admissions related to ADRs in older people was four times higher than in younger people. In addition, we documented that ADRs are more common in elderly patients than in the young [45][46][47][48]. It was recently reported that comorbidity could predict repeat admission for ADRs in older adults [49].…”

Inappropriate prescribing in geriatric patients

“…Over a 10-year period, Gallelli et al [47] found that 55.2% of hospital admissions due to adverse drug reactions were attributed to the prescribing of NSAIDs. Most patients affected were older than age 60 years, with more than one third of these adverse drug reactions affecting the gastrointestinal system [47].…”

“…Over a 10-year period, Gallelli et al [47] found that 55.2% of hospital admissions due to adverse drug reactions were attributed to the prescribing of NSAIDs. Most patients affected were older than age 60 years, with more than one third of these adverse drug reactions affecting the gastrointestinal system [47]. Age is the most common risk factor for NSAID-induced gastrointestinal bleeding; gastrointestinal bleeding occurrence could be reduced by appropriate use of gastroprotective agents (eg, proton pump inhibitors or histamine 2-receptor antagonists).…”

Effects of Phenobarbital and Levetiracetam on PR and QTc Intervals in Patients with Post-Stroke Seizure

“…During this period the therapeutic drug monitoring of phenobarbital and levetiracetam was performed through high-performance liquid chromatography. The development of adverse drug reactions and/or drug-drug interactions was evaluated in agreement with our previous studies [12][13][14][15][16][17][18][19][20].…”